Synthesis and Physico-Chemical Studies of 1, 1'-Substituted Phenyl Cyclohexane

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Microwave irradiated and conventional syntheses of halogenated symmetric double Schiff bases, their spectral and microbial study

ABSTRACT. The aim of the present work was to discover various synthetic route of biological active halogenated symmetric double Schiff bases of 1,1'-bis(4-aminophenyl)cyclohexane, their spectral and microbial study. Symmetric double Schiff base ligands of halogenated benzaldehyde and 1,1'-bis(4-aminophenyl)cyclohexane were synthesized by conventional and green chemistry approach. The purity of Schiff bases was checked by Thin Layer Chromatography (TLC). The structures of these ligands were elucidated by UV, FTIR, 1 HNMR and MS; and assayed for their antibacterial activity against Escherichia coli (E. coli), Bacillus megaterium (B.mega), Proteus vulgaris (P. vulgaris, Staphylococcus aureus (S. aureus) and Aspergillus niger (A. niger)The minimum inhibition concentrations (MIC) of the compounds were studied by cup plate method. Schiff bases revealed moderate antimicrobial activity and good antifungal activity against chosen standard drugs and microorganisms