Comparative study on effect of natural and synthetic superdisintegrants in the formulation of orodispersible tablets

Now-a-days, Orodispersible drug delivery systems are extensively used to improve bioavailability and patient compliance. Over the past three decades, Orodispersible tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance, improved solubility and stability profiles. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. New ODT technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity. In recent years, several newer agents have been developed known as superdisintegrants. The objective of the present article is to highlight the various kinds of superdisintegrants (Natural & Synthetic) along with their role in tablet disintegration and drug release, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance. Keywords: ODTs, Orodispersible tablets, Disintegrants, Superdisintegrants, Natural, and Synthetic

Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants

MDTs is regarding as a good candidates for the patients with persistent nausea, who are traveling, or who have little or no access to water.  The objective of present research work was to prepare and evaluate the mouth dissolving tablet of Lacosamide using Super disintegrants like Guar Gum, and other excipients like Microcrystalline Cellulose and Mannitol in different concentrations by Direct Compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for the epilepsy patients. Effect of different formulation variables i.e. amount of polymer and type of polymer was studied on release profile and other characteristics. The mouth dissolving tablets were prepared by single punch machine using powder blend of superdisintegrant and Lacosamide. Post-compression parameters like Hardness, weight variation, friability, In-Vitro dispersion, Drug content uniformity and In-vitro drug release studies were carried out for all the formulation. All the Formulations gave the result within the official limits. The prepared mouth dissolving tablet shows the properties of fast disintegration time (28 sec to 47 sec) within official limit.  By the in-vitro disintegration, it is concluded that formulation F2 prepared by Guar Gum (10%) showed the fast disintegration time than the MCC. Therefore, it may be concluded that mouth dissolving tablet was suitable choice for delivery system of Lacosamide. Keywords: Lacosamide, Mouth dissolving tablets, Superdisintegrants, Guargum, microcrystalline cellulose, Direct compression method, Antiepileptic drug