Filogenia do gênero Spondias com base em marcadores RAPD resultados preliminares.

O trabalho teve como objetivo, estudar as relações de ancestralidade (filogenia) entre as diferentes Spondias visando agrupar as espécies/híbridos com base em marcadores de DNA do tipo RAPD

Algae as a source of bioactive compounds to prevent the development of type 2 diabetes mellitus

Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. It is considered a new pandemic and its control involves numerous challenges. Although many of the measures are based on improving life habits, diet is also of vital importance due to bioactive compounds present in food. In this regard, several raw materials have been investigated whose bioactivities seem to slow the progression of this disease. Within these matrices, there are algae of importance, such as brown algae, showing to have beneficial effects on glycemic control. These pieces of evidence are increasing every day due to the development of cell or animal models, which lead to the conclusion that bioactive compounds may have direct effects on decreasing hyperglycemia, enhancing insulin secretion and preventing the formation of amyloid plaques.Serbian co-authors thank the Ministry of Education, Science, and Technological Development of the Republic of Serbia for the support within the contracts for the realization and financing of scientific research work in 2021 ; financial support from Programa de Cooperación Interreg V-A España—Portugal (POCTEP) 2014–2020; MICINN supporting the Ramón&Cajal grant for M.A. Prieto; to Xunta de Galicia and University of Vigo supporting the pre-doctoral grants for A.G. Pereira, and P. García-Oliveira; to Ibero-American Program on Science and Technology for financial support. This project has received funding from the Bio Based Industries Joint Undertaking (JU); the JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio Based Industries Consortium.info:eu-repo/semantics/publishedVersio

Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial.

BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamous NSCLC. We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.MethodsWe did an open-label, randomised, phase 3 trial of adult patients (aged ≥18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and who had completely resected stage IB (≥4 cm) to IIIA (defined by the American Joint Committee on Cancer 6th edition) NSCLC. We enrolled patients from across the US National Clinical Trials Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) affiliates in Europe and from the Canadian Cancer Trials Group, within 6-12 weeks of surgery. The chemotherapy regimen for each patient was selected before randomisation and administered intravenously; it consisted of four 21-day cycles of cisplatin (75 mg/m2 on day 1 in all regimens) in combination with investigator's choice of vinorelbine (30 mg/m2 on days 1 and 8), docetaxel (75 mg/m2 on day 1), gemcitabine (1200 mg/m2 on days 1 and 8), or pemetrexed (500 mg/m2 on day 1). Patients in the bevacizumab group received bevacizumab 15 mg/kg intravenously every 21 days starting with cycle 1 of chemotherapy and continuing for 1 year. We randomly allocated patients (1:1) to group A (chemotherapy alone) or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy regimen, stage of disease, histology, and sex. No one was masked to treatment assignment, except the Data Safety and Monitoring Committee. The primary endpoint was overall survival, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00324805.FindingsBetween June 1, 2007, and Sept 20, 2013, 1501 patients were enrolled and randomly assigned to the two treatment groups: 749 to group A (chemotherapy alone) and 752 to group B (chemotherapy plus bevacizumab). 383 (26%) of 1458 patients (with complete staging information) had stage IB, 636 (44%) had stage II, and 439 (30%) had stage IIIA disease (stage of disease data were missing for 43 patients). Squamous cell histology was reported for 422 (28%) of 1501 patients. All four cisplatin-based chemotherapy regimens were used: 377 (25%) patients received vinorelbine, 343 (23%) received docetaxel, 283 (19%) received gemcitabine, and 497 (33%) received pemetrexed. At a median follow-up of 50·3 months (IQR 32·9-68·0), the estimated median overall survival in group A has not been reached, and in group B was 85·8 months (95% CI 74·9 to not reached); hazard ratio (group B vs group A) 0·99 (95% CI 0·82-1·19; p=0·90). Grade 3-5 toxicities of note (all attributions) that were reported more frequently in group B (the bevacizumab group) than in group A (chemotherapy alone) were overall worst grade (ie, all grade 3-5 toxicities; 496 [67%] of 738 in group A vs 610 [83%] of 735 in group B), hypertension (60 [8%] vs 219 [30%]), and neutropenia (241 [33%] vs 275 [37%]). The number of deaths on treatment did not differ between the groups (15 deaths in group A vs 19 in group B). Of these deaths, three in group A and ten in group B were considered at least possibly related to treatment.InterpretationAddition of bevacizumab to adjuvant chemotherapy did not improve overall survival for patients with surgically resected early-stage NSCLC. Bevacizumab does not have a role in this setting and should not be considered as an adjuvant therapy for patients with resected early-stage NSCLC.FundingNational Cancer Institute of the National Institutes of Health

Prognostic role of serum cytokeratin 19 fragments in advanced non-small-cell lung cancer: association of marker changes after two chemotherapy cycles with different measures of clinical response and survival

Prognostic implication of serum cytokeratin 19 fragments (CYFRA 21-1) was explored in 60 advanced NSCLC patients, whereas in 45 patients assessable for serological response a ⩾35% CYFRA 21-1 decline after two chemotherapy cycles was strongly associated with non-progression (NP), defined as a sum of objective response (OR)+stable disease (P<0.0001) and survival (P=0.0002). Association of OR with survival was not significant. In multivariate survival analysis, ⩾35% marker decline and radiological NP status were found as major determinants of prolonged survival with RR: 0.37 (P=0.01) and 0.63 (P=0.01), respectively. In advanced NSCLC patients, NP reflects therapeutic efficacy better than traditional OR. CYFRA 21-1 ⩾35% decline seems to be a reliable surrogate marker of treatment efficacy in terms of survival

Associations between tooth wear and dental sleep disorders : A narrative overview

Objectives Tooth wear is a common finding in adult patients with dental sleep disorders. The aim of this paper was to review the literature on the possible associations between tooth wear and the following dental sleep disorders: sleep-related oro-facial pain, oral moistening disorders, gastroesophageal reflux disease (GERD), obstructive sleep apnoea syndrome (OSAS) and sleep bruxism. Methods A PubMed search was performed on 1 June 2018 using MeSH terms in the following query: Tooth Wear AND (Facial Pain OR Temporomandibular Joint Disorders OR Xerostomia OR Sialorrhea OR Gastroesophageal Reflux OR Sleep Apnea Syndrome OR Sleep Bruxism). Results The query yielded 706 reports on tooth wear and the mentioned dental sleep disorders. Several associations between tooth wear and the dental sleep disorders were suggested in the literature. It could be concluded that: (a) tooth wear is associated with dental pain and/or hypersensitivity; (b) oral dryness is associated with tooth wear, oro-facial pain and sleep bruxism; (c) GERD is associated with tooth wear, oro-facial pain, oral dryness, OSAS and sleep bruxism; (d) OSAS is associated with oral dryness, GERD and sleep bruxism; and (e) sleep bruxism is associated with tooth wear. Conclusions Tooth wear is associated with the dental sleep disorders oro-facial pain, oral dryness, GERD and sleep bruxism. The dental sleep disorders are interlinked with each other, which leads to indirect associations as well, and makes the consequences of each single condition difficult to disentangle. Knowledge of these associations is clinically relevant, but more research is needed to confirm their validity.Peer reviewe

A incorporação de bromélias epífitas no processo de restauração de áreas degradadas na mata atlântica: um estudo em Registro, SP.

Tradicionalmente os modelos de recuperação ambiental têm sido baseados em técnicas que contemplam apenas o componente arbóreo da vegetação, desconsiderando outras formas de vida responsáveis por boa parte da riqueza e complexidade estrutural de uma comunidade tropical. As bromélias têm indiscutível importância na dinâmica das formações vegetais sob domínio atlântico, destacando sua capacidade em criar microhabitats e ofertar recursos alimentares para animais, entre os quais, polinizadores e dispersores. Este trabalho teve como objetivo propor ações e subsidiar a incorporação de bromélias epífitas no processo de restauração ecológica, baseado nos dados referentes à sua distribuição horizontal e vertical na vegetação do entorno do Aeroporto de Registro (SP). As populações presentes nas árvores em uma área de 800m² foram quantificadas, identificadas e hierarquizadas quanto à sua aptidão para introdução no processo de restauração, de acordo com os seguintes parâmetros: i) Valor de Importância Epifítica (VIE), calculado a partir da soma das freqüências e densidades relativas, ii) preferência por luz, iii) presença em florestas secundárias e iv) resistência a danos. Aechmea nudicaulis, A. organensis, Tillandsia stricta, foram populações que apresentaram maior aptidão para introdução no processo de restauração da área. A proposta contempla a colocação de poleiros com estas espécies de bromélias ao longo da área em processo de restauração, como estratégia para aumentar a probabilidade da presença de animais polinizadores e dispersores. Quanto às árvores-suporte, constatou-se que há entre as espécies importantes na estrutura arbórea, algumas mais favoráveis ao estabelecimento de epífitas, como Andira fraxinifolia, Coussapoua microcarpa, Nectandra oppositifolia, Calophyllum brasiliense, Tapirira guianensis. Estas espécies devem ser priorizadas na restauração, uma vez que podem ser futuramente colonizadas por propágulos de bromélias, presentes em abundância na vegetação adjacente

Estrutura populacional de espécies florestais não madeireiras em assentamento extrativista e de colonização, Porto Acre-AC.

Este trabalho elaborou um estudo sobre o comportamento ecológico de quatro espécies florestais importantes economicamente (Seringueira - Hevea brasiliensis Arg., Castanheira - Bertholletia excelsa H.B.K., Açaí - Euterpe precatoria Mart e Andiroba - Carapa guianensis Aublet), em dois tipos de assentamentos (PAE e PC recém criado)