41 research outputs found
Uncovering the Importance of Selenium in Muscle Disease
A connection between selenium bioavailability and development of muscular
disorders both in humans and livestock has been established for a long time.
With the development of genomics, the function of several selenoproteins was
shown to be involved in muscle activity, including SELENON, which was linked to
an inherited form of myopathy. Development of animal models has helped to dissect
the physiological dysfunction due to mutation in the SELENON gene; however the
molecular activity remains elusive and only recent analysis using both in vivo and
in vitro experiment provided hints toward its function in oxidative stress defence
and calcium transport control. This review sets out to summarise most recent findings
for the importance of selenium in muscle function and the contribution of this
information to the design of strategies to cure the diseases