Comparación de distintas estrategias para la predicción de muerte a corto plazo en el paciente anciano infectado

Objective. The aim of this study was to determine the utility of a post hoc lactate added to SIRS and qSOFA score to predict 30-day mortality in older non-severely dependent patients attended for infection in the Emergency Department (ED). Methods. We performed an analytical, observational, prospective cohort study including patients of 75 years of age or older, without severe functional dependence, attended for an infectious disease in 69 Spanish ED for 2-day three seasonal periods. Demographic, clinical and analytical data were collected. The primary outcome was 30-day mortality after the index event. Results. We included 739 patients with a mean age of 84.9 (SD 6.0) years; 375 (50.7%) were women. Ninety-one (12.3%) died within 30 days. The AUC was 0.637 (IC 95% 0.587-0.688; p= 2 and 0.698 (IC 95% 0.635- 0.761; p= 2. Comparing receiver operating characteristic (ROC) there was a better accuracy of qSOFA vs SIRS (p=0.041). Both scales improve the prognosis accuracy with lactate inclusion. The AUC was 0.705 (IC95% 0.652-0.758; p<0.001) for SIRS plus lactate and 0.755 (IC95% 0.696-0.814; p<0.001) for qSOFA plus lactate, showing a trend to statistical significance for the second strategy (p=0.0727). Charlson index not added prognosis accuracy to SIRS (p=0.2269) or qSOFA (p=0.2573). Conclusions. Lactate added to SIRS and qSOFA score improve the accuracy of SIRS and qSOFA to predict short-term mortality in older non-severely dependent patients attended for infection. There is not effect in adding Charlson index

Virtual Reality as a Tool for Cognitive Behavioural Therapy: A Review.

This chapter describes the deployment of Virtual Reality (VR) for Cognitive Behavioral Therapy (CBT) to treat anxiety and other psychological disorders. Regarding anxiety, the most common technique is constituted of Exposure Therapy that, transposed to Virtual Reality, allows the patient to face a digital version of the feared object or situation, instead of a real or imaginal one. Virtual Reality Exposure Therapy (VRET) has proved effective in the treatment of anxiety disorders such as social phobia, Post-Traumatic Stress Disorder (PTSD), and panic disorder with agoraphobia and has shown an efficacy comparable to traditional in-vivo exposure with various specific phobias such as arachnophobia, acrophobia, and fear of flying. Thanks to its versatility, VR has also found an employment within the CBT framework with other psychological disorders, such as substance abuse, eating disorders, and in inducing non-pharmacological analgesia in patients undergoing painful medical procedures. Even when VR-based therapy does not lead to better results than traditional CBT in terms of efficacy, there are several reasons for preferring it over in-vivo exposure, including patient\u2019s comfort and safety, as well as the possibility to create complex or delicate scenarios (e.g. PTSD scenarios). In addition, VRET can be employed to facilitate the transition toward fearful objects in the real world in patients who would otherwise refuse to face real stimuli