7 research outputs found
The climate-triggered western shift of the confluence between the Dora Baltea and Po rivers (north-western Italy) during the late Holocene
No full textPostnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays
No full textGBA2-Encoded β-Glucosidase Activity Is Involved in the Inflammatory Response to Pseudomonas aeruginosa
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From archeological layers to schematic rock art? Integrated study of the Neolithic pigments and pigmented rocks at the Rocher du Château (Western Alps, Savoie, France)
No full textTranscription factor decoy: a pre-transcriptional approach for gene downregulation purpose in cancer
No full textDysregulation of the basal RNA polymerase transcription apparatus in cancer
No full textMutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation, but the frequency of new anticancer drugs that selectively target defective transcription apparatus entering the clinic has been limited. This is because targeting the large protein–protein and protein–DNA interfaces that control both generic and selective aspects of RNA polymerase transcription has proved extremely difficult. However, recent technological advances have led to a 'quantum leap' in our comprehension of the structure and function of the core RNA polymerase components, how they are dysregulated in a broad range of cancers and how they may be targeted for 'transcription therapy'
