The use of the enneagram to improve customer relationships with a motor vehicle manufacturer

Marketing strategy relies heavily on segmentation and positioning. Lifestyle and psychographics are increasingly being used as a basis for market segmentation. Marketers require deeper insight into the motivational factors that encourage purchases in order to tailor make offerings to suit individual needs. The focus is on customer relationship management in order to retain customers over a longer period of time, rather than once-off sales. This study examines how using the ancient and mystical technique of the Enneagram can improve customer relationship management and formulates a model for doing so. The Enneagram can be used as an effective base for psychographic segmentation by harnessing the diagnostic and predicative power therein. It is already being used in human resource development and strategic planning by companies and it seems fitting to apply it in yet another business area that can greatly benefit from this

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection