1 research outputs found
Structural and Functional Properties of IL-4δ2, an Alternative Splice Variant of Human IL-4
Structural and functional properties of recombinant IL-4δ2, a naturally occurring splice variant of human IL-4 with a deletion of the loop region 22â37, have been analyzed. IL-4δ2 has Îą-helical structure and most likely preserves the âupâupâdownâdownâ topology typical of the four-helix-bundle cytokines. IL-4δ2 interacts specifically with the Îą chain of IL-4R and competes effectively with IL-4 for the common binding sites. Thus, IL-4δ2 may act as a regulator of the cytokine net, being the natural antagonist of IL-4