858 research outputs found

    Cancer gene therapy clinical trials: lessons for the future

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    Translation and Validation of the Greek Version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ)

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    Introduction Sexual dysfunction in patients with psychoses may be associated with the psychiatric illness itself (negative symptoms, such as apathy, and avolition), comorbid somatic health, psychosocial factors (stigmatization, discrimination), and the use of psychotropic drugs. In Greece, research into the study of antipsychotic-induced sexual dysfunction is not sufficient. Aim This study was conducted to translate and validate the Greek version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ) in a sample of patients receiving antipsychotic treatment. Methods A “forward-backward translation” method was applied. A pilot study was conducted with 15 outpatients with schizophrenia and bipolar disorder under antipsychotics treatment. Patients also completed the “Subjects’ Response to Antipsychotics (SRA)” questionnaire in order to assess the validity of the ASFQ. The ASFQ and the SRA questionnaire were completed twice within 2 weeks. Main outcome measures Reliability (internal consistency and test-retest) and validity were assessed. Results The Greek translation of ASFQ was reliable, with excellent internal consistency (Cronbach's a = 0.90 for men and 0.95 for women in both measurements). In addition, the Spearman correlation coefficient was 1 (P< .001) in all Likert-type questions in both assessments. Finally, Spearman correlation coefficients between ASFQ and SRA were moderately positive to strongly positive (between 0.25 and 1) in both assessments, demonstrating moderate to high validity. Conclusions The Greek version of the ASFQ has proved to be a reliable and valid clinical instrument, hence it can be used in further studies in the Greek population. Angelaki M, Galanis P, Igoumenou A, et al. Translation and Validation of the Greek Version of the Antipsychotics and Sexual Functioning Questionnaire (ASFQ). J Sex Med 2021;9:100334

    Electricity Generation from Low Temperature Sources

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    Power plants using conventional processes and unconventional fluids have a significant potential for the valorization of low and medium temperature renewable energy sources as well as waste heat from industrial, commercial or institutional installations. This review paper describes some prototypes of such power plants and summarizes some of the relevant scientific and technical literature. An analysis based on the first and second laws of thermodynamics and basic heat transfer relations is used to illustrate the operational limits and performance characteristics of these power plants

    Esophageal Small Cell Carcinoma with Synchronous Renal Cell Carcinoma: A Case Report with Review of the Literature

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    Synchronous malignancies with an esophageal malignancy are not uncommon. However synchronous esophageal and renal cell carcinoma (RCC) is rare with only 11 cases reported in the world literature, the esophageal malignancies being adenocarcinomas or squamous cell carcinomas. Here, we report the first case of synchronous small cell carcinoma (SCC) of the esophagus with a RCC. SCC of the esophagus is an aggressive malignancy with poor prognosis constituting 0.8–2.4% of all esophageal malignancies, currently treated with induction chemotherapy followed by chemoradiotherapy. Our patient underwent chemoradiotherapy for the SCC of the esophagus followed by radical nephrectomy for the RCC. He developed metastatic disease and died 8 months after diagnosis. Larger case series are required to develop a treatment algorithm for such a rare presentation. The key points of this report are: (1) Synchronous RCC with a primary esophageal carcinoma is a rare presentation. (2) This is the first described case report of a SCC of the esophagus with a synchronous RCC. (3) Overall prognosis in a synchronous presentation is determined by the primary esophageal malignancy. (4) Esophageal carcinomas with synchronous malignancies have a poorer prognosis compared to isolated esophageal carcinoma

    Coupling and Decoupling Relationships between Energy Consumption and Air Pollution from the Transport Sector and the Economic Activity

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    In the present paper an analysis of whether and under which conditions coupling or decoupling exists between growth rates (as reflecting in GDP rates) of the economy and energy consumption and air pollution from the transport sector. An extensive time period from 1995 to 2012 is surveyed and divided into two periods, from 1995 to 2008 (growth period) and from 2008 to 2012 (recession period). The analysis is conducted for the 28 European Union countries and illustrates, for most of these countries, a coupling phenomenon for the growth period and a decoupling phenomenon for the recession period. This finding may be essential for the further institutional steps to be undertaken, in view of the reduction of CO2 and of energy conservation. Keywords: Coupling; Decoupling; Transportation; Environment; Sustainability JEL Classifications: H23; O44; R4; Q53
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