Towards One Tonne Direct WIMP Detectors: Have we got what it takes?

Experimentally have we got what it takes to pursue the direct observation of WIMP interactions down to sensitivities of a few events /100 kg/year? For a Ge target with a low energy threshold (<20 keVr) this corresponds to a WIMP-nucleon sigma~10^-46 cm^2. A number of recent theoretical papers, making calculations in SUSY-based frameworks, show many (>5) orders of magnitude spread in the possible interaction rates for models consistent with existing Cosmology and Accelerator bounds. Some theorists, but certainly not all, are able to generate models, that lead to interaction rates at the few /kg/day that would be implied by the current DAMA annual modulation signal. All theorists demonstrate models that generate much lower interaction rates. This paper takes an unashamed experimentalist`s view of the issues that arise when looking forward to constructing 1 tonne WIMP detectors.Comment: 12 pages (TeX), 6 figures (eps); IDM2000 3rd International Workshop on the Identification of Dark Matter, York, UK, to be published in proceedings Eds. N. J. C. Spooner and V. Kudryavtsev, World Scientific, Singapore, 2001. Slides available at http://www.hep.ucl.ac.uk/~gaitske

Some model-independent phenomenological consequences of flexible brane worlds

In this work we will review the main properties of brane-world models with low tension. Starting from very general principles, it is possible to obtain an effective action for the relevant degrees of freedom at low energies (branons). Using the cross sections for high-energy processes involving branons, we set bounds on the different parameters appearing in these models. We also show that branons provide a WIMP candidate for dark matter in a natural way. We consider cosmological constraints on its thermal and non-thermal relic abundances. We derive direct detection limits and compare those limits with the preferred parameter region in the case in which the EGRET excess in the diffuse galactic gamma rays is due to dark matter annihilation. Finally we will discuss the constraints coming from the precision tests of the Standard Model and the muon anomalous magnetic moment.Comment: 10 pages, 6 figures. Contribution to the Proceedings of the Second International Conference on Quantum Theories and Renormalization Group in Gravity and Cosmology, IRGAC 2006, Barcelona, 11-15 July, 200

Simulation results for a low energy nuclear recoil yields measurement in liquid xenon using the MiX detector

Measuring the scintillation and ionization yields of liquid xenon in response to ultra-low energy nuclear recoil events is necessary to increase the sensitivity of liquid xenon experiments to light dark matter. Neutron capture on xenon can be used to produce nuclear recoil events with energies below $0.3$ keV$_\text{NR}$ via the asymmetric emission of $\gamma$ rays during nuclear de-excitation. The feasibility of an ultra-low energy nuclear recoil measurement using neutron capture was investigated for the Michigan Xenon (MiX) detector, a small dual-phase xenon time projection chamber that is optimized for a high scintillation gain. Simulations of the MiX detector, a partial neutron moderator, and a pulsed neutron generator indicate that a population of neutron capture events can be isolated from neutron scattering events. Further, the rate of neutron captures in the MiX detector was optimized by varying the thickness of the partial neutron moderator, neutron pulse width, and neutron pulse frequency.Comment: 7 pages, 5 figures. LIDINE 2022 proceeding

Superweakly interacting dark matter from the Minimal Walking Technicolor

We study a superweakly interacting dark matter particle motivated by minimal walking technicolor theories. Our WIMP is a mixture of a sterile state and a state with the charges of a standard model fourth family neutrino. We show that the model can give the right amount of dark matter over a range of the WIMP mass and mixing angle. We compute bounds on the model parameters from the current accelerator data including the oblique corrections to the precision electroweak parameters, as well as from cryogenic experiments, Super-Kamiokande and from the IceCube experiment. We show that consistent dark matter solutions exist which satisfy all current constraints. However, almost the entire parameter range of the model lies within the the combined reach of the next generation experiments.Comment: 29 pages, 6 figure

Determining the Mass of Dark Matter Particles with Direct Detection Experiments

In this article I review two data analysis methods for determining the mass (and eventually the spin-independent cross section on nucleons) of Weakly Interacting Massive Particles with positive signals from direct Dark Matter detection experiments: a maximum likelihood analysis with only one experiment and a model-independent method requiring at least two experiments. Uncertainties and caveats of these methods will also be discussed.Comment: 24 pages, 10 figures, 1 reference added, typos fixed, published version, to appear in the NJP Focus Issue on "Dark Matter and Particle Physics

Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels

Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and the phosphodiesterases which degrade these compounds. In this paper, we employ a systems biology approach to develop mathematical models of these networks that, for the first time, take into account the different biochemical properties of the isoforms involved. To investigate the mechanisms underlying the joint regulation of cAMP and cGMP, we apply our models to analyse the regulation of cilia beat frequency in Paramecium by Ca(2+). Based on our analysis of these models, we propose that the diversity of isoform combinations that occurs in living cells provides an explanation for the huge variety of intracellular processes that are dependent on these networks. The inclusion of both G-protein receptor and Ca(2+)-dependent regulation of AC in our models allows us to propose a new explanation for the switching properties of G-protein subunits involved in nucleotide regulation. Analysis of the models suggests that, depending on whether the G-protein subunit is bound to AC, Ca(2+) can either activate or inhibit AC in a concentration-dependent manner. The resulting analysis provides an explanation for previous experimental results that showed that alterations in Ca(2+) concentrations can either increase or decrease cilia beat frequency over particular Ca(2+) concentration ranges

Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies.

BACKGROUND: Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. METHODS: Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. FINDINGS: During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with <5 years of use (RR 1·43, 95% CI 1·31-1·56; p<0·0001). Combining current-or-recent use (any duration, but stopped <5 years before diagnosis) resulted in an RR of 1·37 (95% CI 1·29-1·46; p<0·0001); this risk was similar in European and American prospective studies and for oestrogen-only and oestrogen-progestagen preparations, but differed across the four main tumour types (heterogeneity p<0·0001), being definitely increased only for the two most common types, serous (RR 1·53, 95% CI 1·40-1·66; p<0·0001) and endometrioid (1·42, 1·20-1·67; p<0·0001). Risk declined the longer ago use had ceased, although about 10 years after stopping long-duration hormone therapy use there was still an excess of serous or endometrioid tumours (RR 1·25, 95% CI 1·07-1·46, p=0·005). INTERPRETATION: The increased risk may well be largely or wholly causal; if it is, women who use hormone therapy for 5 years from around age 50 years have about one extra ovarian cancer per 1000 users and, if its prognosis is typical, about one extra ovarian cancer death per 1700 users. FUNDING: Medical Research Council, Cancer Research UK