Behavioural science principles for scaling-up zero tillage wheat and maize in the Eastern Terai region of Nepal

Farmers have a set of convictions and tend to do what their forefathers had practiced. By identifying their beliefs and designing appropriate ways of upscaling to convince them of new and improved practices, we can improve the adoption of zero tillage technology for maize and wheat. Small and fragmented landholdings that resulted from the cultural system of distributing land to heirs are diverse in their cropping requirements. Moreover, farmers are risk-averse and do not believe easily in new technologies. Traditional extension approaches have not been effective in upscaling these technologies. A new way of thinking based on behavioural science can provide some insights and guidelines for improving the effectiveness of technology adoption. Understanding farmers' socioeconomic circumstances and their decision-making system at the household and society level can help in designing upscaling approaches. Approaches such as capitalising on social bonding, use of established technology leaders, and use of farmers' organizations can improve adoption. Recommended strategies include encouraging a comprehensive contracting system of service provision, using active community influential local leaders in technology expansion, taking group and social identity approaches in technology extension, and capacity building programs for service providers/operators and farmers to help raise confidence and to remove perceived barriers to technology adoption. &nbsp

The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation.

Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably, emerging literature describes the role of immunoregulatory semaphorins and their receptors, plexins and neuropilins, as modulators of innate immunity and diseases defined by acute injury to the kidneys, abdomen, heart and lungs. In this review we discuss the pathogenic functions of semaphorins in clinical conditions of acute inflammation, including sepsis and acute lung injury, with a focus on regulation of the innate immune response as well as potential future therapeutic targeting

Understanding the Fate and Persistence of Herbicides in Soils

Chemical weed control, using herbicides to manage weeds, is an important production practice in citrus groves. Herbicides applied in groves can end up in the soils when the spray hits the soil surface or when herbicides or their metabolite (degradation products) are released from decomposing weed tissues. Subsequently, their fate and persistence in citrus groves are determined by processes such as soil binding, leaching, and degradation. Understanding these processes helps growers in selecting an effective chemical weed management strategy while minimizing the impacts on the crop and environment. Peer reviewed through UF/IFAS Citrus Research and Education Center; published in Citrus Industry Magazine.

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International audienc

Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension.

Interferonopathies, interferon (IFN)-α/β therapy, and caveolin-1 (CAV1) loss-of-function have all been associated with pulmonary arterial hypertension (PAH). Here, CAV1-silenced primary human pulmonary artery endothelial cells (PAECs) were proliferative and hypermigratory, with reduced cytoskeletal stress fibers. Signal transducers and activators of transcription (STAT) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) were both constitutively activated in these cells, resulting in a type I IFN-biased inflammatory signature

May measurement month 2018: an analysis of blood pressure screening results from Nepal.

Raised blood pressure (BP) is a leading risk factor for mortality globally and in Nepal. May Measurement Month (MMM) is a global initiative aimed at screening for hypertension and raising awareness on high BP worldwide. This study provides the results of the 2018 MMM (MMM18) in Nepal. An opportunistic cross-sectional survey of volunteers aged ≥18 years was carried out in May 2018 nationwide. The standard MMM protocol was followed for BP measurement, the definition of hypertension, and statistical analysis. The campaign was publicized through various social media for recruiting volunteers and inviting participation. A total of 15 561 (58.7% male) from 35 districts of Nepal were screened in MMM18, of which 4 321 (27.8%) had hypertension. A total of 2 633 (19.0%) of 13 873 individuals who were not on antihypertensive treatment were found to be hypertensive. Of those on medication, 799 (47.4%) had uncontrolled BP. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher in people on antihypertensive treatment, smokers, and alcohol drinkers compared with those who were not on antihypertensive treatment, smokers, and alcohol drinkers, respectively. Likewise, SBP and DBP steadily increased across increasing body mass index categories. MMM18 was the largest BP screening campaign undertaken in Nepal. MMM has highlighted the importance of a periodic public health program at the national level to increase awareness on hypertension detection and control rate, and thus, the prevention of cardiovascular diseases