Prevalence of vitamin D deficiency in patients with spinal cord injury at admission: a single-centred study in the UK

Vitamin D deficiency is prevalent in patients with chronic spinal cord injury (SCI) and has been implicated as an aetiologic factor of osteoporosis and various skeletal and extra-skeletal issues in SCI patients. Few data were available regarding vitamin D status in patients with acute SCI or immediately assessed at hospital admission. This retrospective cross-sectional study evaluated vitamin D status in SCI patients at admission to a UK SCI centre in January–December 2017. A total of 196 eligible patients with serum 25(OH)D concentration records at admission were recruited. The results found that 24 % were vitamin D deficient (serum 25(OH)D < 25 nmol/l), 57 % of the patients had serum 25(OH)D < 50 nmol/l. The male patients, patients admitted in the winter–spring time (December–May), and patients with serum sodium < 135 mmol/l or with non-traumatic causes had a significant higher prevalence of vitamin D deficiency than their counterparts (28 % males v. 11⋅8 % females, P = 0⋅02; 30⋅2 % in winter–spring v. 12⋅9 % in summer–autumn, P = 0⋅007; 32⋅1 % non-traumatic v. 17⋅6 % traumatic SCI, P = 0⋅03; 38⋅9 % low serum sodium v. 18⋅8 % normal serum sodium, P = 0⋅010). There was a significant inverse association of serum 25(OH)D concentration with body mass index (BMI) (r = −0⋅311, P = 0⋅002), serum total cholesterol (r = −0⋅168, P = 0⋅04) and creatinine concentrations (r = −0⋅162, P = 0⋅02) that were also significant predictors of serum 25(OH)D concentration. Strategies for systematic screening and efficacy of vitamin D supplementation in SCI patients need to be implemented and further investigated to prevent the vitamin D deficiency-related chronic complications

Development strategy of service sector in conditions of federal states entities autonomy increasing

© 2016, Econjournals. All rights reserved.The relevance of the study is caused by the necessity to develop the sphere of services as a component of balanced socio-economic development of Federal State’s territories. The purpose of the paper is to define strategies for the development of services in conditions of increasing independence of the Federal State’s entities. A leading approach is the institutional one that considers the strategy of development of service sector in the Federal State as long-term programs of transition to innovative socially oriented type of economic development, reducing interregional differentiation in the level and quality of life of the population, creating equal opportunities for citizens and promoting human development. In the conditions of Federal State entities’ autonomy increasing the strategy of development in the sphere of services consists of citizens’ life conditions and social environment’ quality improving; accelerated development of human potential; competitiveness improving of human and ensuring it economic social sectors’ capital; development of competitive service markets; improving of the efficiency of politico-legal institutions providing social services to the population. Strategies’ defining for the development of services in the conditions of Federal State entities’ autonomy increasing is based on the principles of subsidiarity, sustainability, selectivity, fractals and transvers. Certain strategies of development of services are aimed at reducing territorial socio-economic differentiation to the level, caused by objective differences of the Federation’s entities, as well as ensuring the balance of the revenue base and expenditure commitments

Commitment of the adult population (parents) and children to vaccine prevention under the conditions of the spread of new coronaviral infection COVID-2019

The work shows the level of awareness and attitude of parents, children and adolescents to vaccination as a method of preventing infectious diseases, an analysis of the vaccination of adults and children against influenza was carried out using the example of the studied sample over the past 5 years, and the readiness of the selected contingent to be vaccinated against coronavirus infection was assessed (COVID-19).В работе показаны уровень осведомленности и отношение родителей, детей и подростков к вакцинации, как к методу профилактики инфекционных заболеваний, проведен анализ привитости взрослого и детского населения от гриппа на примере изучаемой выборки за последние 5 лет, оценена готовность выбранного контингента к прививкам против коронавирусной инфекции (COVID-19

Assessment of adherence to treatment of patients on program hemodialysis during the covid-19 pandemic

The aim of the study - to assess the degree of adherence of patients on program hemodialysis during the NCVI pandemic to various treatment methods using the ESRD-AQ questionnaire.Цель исследования - оценить степень приверженности пациентов на программном гемодиализе в период пандемии НКВИ к различным методам лечения с использованием опросника ESRD-A

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network analysis applied to three large-scale transcriptional datasets: we introduce (1) an ImmGen MNP open-source dataset of 337 samples across 26 tissues; (2) a myeloid subset of ImmGen Phase I dataset (202 MNP samples); and (3) a myeloid mouse single-cell RNA sequencing (scRNA-seq) dataset (51,364 cells) assembled based on Tabula Muris Senis. To analyze such large-scale datasets, we develop a network-based computational approach, genes and metabolites (GAM) clustering, for unbiased identification of the key metabolic subnetworks based on transcriptional profiles. We define 9 metabolic subnetworks that encapsulate the metabolic differences within MNP from 38 different tissues. Obtained modules reveal that cholesterol synthesis appears particularly active within the migratory dendritic cells, while glutathione synthesis is essential for cysteinyl leukotriene production by peritoneal and lung macrophages

ENTREPRENEURIAL ASPECTS OF THE PERSONALITY-ORIENTED APPROACH TO IMPROVE THE SKILLS OF MANAGERIAL STAFF

Статья посвящена структурному исследованию исследуемого феномена личностного потенциала на основе обзора различных подходов, изучающих отдельные составляющие личностного потенциала. В статье рассматриваются теоретические и практические разработки вопросов понятия личностного потенциала, места изучаемого феномена в управленческой деятельности, определения структуры и факторов, влияющих на успешность реализации внутренних резервов управленческого персонала, требующих пристального внимания со стороны представителей разных наук.The article is devoted structural studies of the phenomenon of personal potential on the basis of a review of different approaches to examine individual components of personal potential. The article discusses the theoretical and practical issues of development of the concept of personal potential, place the phenomenon under study in management, structure determination and the factors influencing the success of the internal reserves management personnel requiring attention from the representatives of the different sciences

Development strategy of service sector in conditions of federal states entities autonomy increasing

© 2016, Econjournals. All rights reserved.The relevance of the study is caused by the necessity to develop the sphere of services as a component of balanced socio-economic development of Federal State’s territories. The purpose of the paper is to define strategies for the development of services in conditions of increasing independence of the Federal State’s entities. A leading approach is the institutional one that considers the strategy of development of service sector in the Federal State as long-term programs of transition to innovative socially oriented type of economic development, reducing interregional differentiation in the level and quality of life of the population, creating equal opportunities for citizens and promoting human development. In the conditions of Federal State entities’ autonomy increasing the strategy of development in the sphere of services consists of citizens’ life conditions and social environment’ quality improving; accelerated development of human potential; competitiveness improving of human and ensuring it economic social sectors’ capital; development of competitive service markets; improving of the efficiency of politico-legal institutions providing social services to the population. Strategies’ defining for the development of services in the conditions of Federal State entities’ autonomy increasing is based on the principles of subsidiarity, sustainability, selectivity, fractals and transvers. Certain strategies of development of services are aimed at reducing territorial socio-economic differentiation to the level, caused by objective differences of the Federation’s entities, as well as ensuring the balance of the revenue base and expenditure commitments

Development strategy of service sector in conditions of federal states entities autonomy increasing

© 2016, Econjournals. All rights reserved.The relevance of the study is caused by the necessity to develop the sphere of services as a component of balanced socio-economic development of Federal State’s territories. The purpose of the paper is to define strategies for the development of services in conditions of increasing independence of the Federal State’s entities. A leading approach is the institutional one that considers the strategy of development of service sector in the Federal State as long-term programs of transition to innovative socially oriented type of economic development, reducing interregional differentiation in the level and quality of life of the population, creating equal opportunities for citizens and promoting human development. In the conditions of Federal State entities’ autonomy increasing the strategy of development in the sphere of services consists of citizens’ life conditions and social environment’ quality improving; accelerated development of human potential; competitiveness improving of human and ensuring it economic social sectors’ capital; development of competitive service markets; improving of the efficiency of politico-legal institutions providing social services to the population. Strategies’ defining for the development of services in the conditions of Federal State entities’ autonomy increasing is based on the principles of subsidiarity, sustainability, selectivity, fractals and transvers. Certain strategies of development of services are aimed at reducing territorial socio-economic differentiation to the level, caused by objective differences of the Federation’s entities, as well as ensuring the balance of the revenue base and expenditure commitments