Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer.

This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated

Résection antérieure du rectum laparoscopique

ERMANational audienc

Pancréatectomie gauche laparoscopique avec conservation plénique

ERMANational audienc

Résection laparoscopique d'une lésion kystique péritonéale

ERM

Pancréatectomie gauche laparoscopique avec conservation splénique [vidéo]

ERMANational audiencehttp://www.chirurgie-viscerale.org/Data/didactinets/SFCL2009/Vendredi%2023/Salle%20Bordeaux/14h00/Alain-Gainant/Media/index.ht

Faut-il opérer les hernies occultes controlatérales découvertes lors du traitement laparoscopique d'une hernie inguinale

ERM

Les récidives post-chirurgicales de la maladie de Crohn (prise en charge médico-chirurgicale)

LIMOGES-BU Médecine pharmacie (870852108) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Anneaux gastriques (une expérience de six ans)

LIMOGES-BU Médecine pharmacie (870852108) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients.

The lipid mediator platelet-activating factor (PAF) plays a role in cancer. We investigated its presence in human colon carcinoma by assessing the levels of tissue phospholipase A(2) (PLA(2), the key enzyme in the generation of the lyso-PAF precursor), lyso-PAF, PAF and acetylhydrolase activity (AHA, the key enzyme in PAF degradation) in colorectal cancer patients and by correlating them with Dukes' classification. The results highlighted that the tumour tissues of Dukes' A and B patients had significantly higher PLA(2), lyso-PAF, PAF and AHA levels as compared with nontumour tissues. Dukes' C patients had higher PLA(2), lyso-PAF and AHA levels but unchanged PAF. Dukes' D patients had higher AHA levels but unchanged PLA(2), lyso-PAF and PAF. A pathophysiological role for PAF is suggested in human colon carcinoma