64 research outputs found
'Magic coins' and 'magic squares': the discovery of astrological sigils in the Oldenburg Letters
Get PDFEnclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637–1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modern beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities
Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis
Get PDF<p>Abstract</p> <p>Background</p> <p>Low levels of oxygen in tissues, seen in situations such as chronic lung disease, necrotic tumors, and high altitude exposures, initiate a signaling pathway that results in active transcription of genes possessing a hypoxia response element (HRE). The aim of this study was to investigate whether a change in miRNA expression following hypoxia could account for changes in the cellular transcriptome based on currently available miRNA target prediction tools.</p> <p>Methods</p> <p>To identify changes induced by hypoxia, we conducted mRNA- and miRNA-array-based experiments in HT29 cells, and performed comparative analysis of the resulting data sets based on multiple target prediction algorithms. To date, few studies have investigated an environmental perturbation for effects on genome-wide miRNA levels, or their consequent influence on mRNA output.</p> <p>Results</p> <p>Comparison of miRNAs with predicted mRNA targets indicated a lower level of concordance than expected. We did, however, find preliminary evidence of combinatorial regulation of mRNA expression by miRNA.</p> <p>Conclusion</p> <p>Target prediction programs and expression profiling techniques do not yet adequately represent the complexity of miRNA-mediated gene repression, and new methods may be required to better elucidate these pathways. Our data suggest the physiologic impact of miRNAs on cellular transcription results from a multifaceted network of miRNA and mRNA relationships, working together in an interconnected system and in context of hundreds of RNA species. The methods described here for comparative analysis of cellular miRNA and mRNA will be useful for understanding genome wide regulatory responsiveness and refining miRNA predictive algorithms.</p
Ephemerides of the Celestial Motions and aspects, eclipses of the luminaries, etc. for XX years.
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The scurrilous scribler dissected: or, A word in William Lilly's ear concerning his reputation, which he complains is injured by J.G. that ungrateful scorpionist, as he the said Lilly scurrilously terms him.
No full textAstrological predictions for the year, 1679 shewing, according to the most approv'd of rules of that sublime study, what revolutions, or accidents, are likely to happen in many parts of the world, especially in England, Scotland, and Ireland / by J.G. ...
No full textBritains royal star: Or, An astrological demonstration of Englands future felicity; deduced from the position of the heavens as they beheld the earth in the meridian of London, at the first proclaiming of his Sacred Majesty King Charles the second, on May 8. 10h. 56m. A.M. 1660. And an enquiry made into the use and abuse of astrologie, resolving whether it be convenient to be continued or contemned. Also, an admirable observation of a conjunction of Jupiter and Mars made in the year 1170. by a learned monck of Canterbury, communicated to the learned in astronomy. Together with an exaination and refutation of that nest of sedition, published by Mr. H. Jessey, concerning frogs, dogs, &c. in his pamplet falsly intituled, The Lods Loud call to England, &c. By John Gadbury, philomathematicus.
No full textMagna veritas, or, John Gadbury, student in physick and astrology, not a papist but a true Protestant of the Church of England published for the satisfaction of all such as know not the said John Gadbury and yet give credit to all kinds of scandals and falshoods that pass upon his much injured reputation since his late unfortunate confinement.
No full textA brief relation of the life and death of the late famous astrologer, Mr. Vincent Wing Together with his nativity, as it was done, many years before his death, by his own hand; and now, for general satisfaction, made publick. By J.G. philomathētikos.
No full textThe nativity of the most valiant and puissant monarch, Lewis the fourteenth, king of France and Navarre astronomically and astrologically handled.
No full textLondon's deliverance predicted in a short discourse shewing the cause of plagues in general, and the probable time (God not contradicting the course of second causes) when the present pest may abate, &c. / by John Gadbury.
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