The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Level of biathlete coordination skills of biathletes: Representatives of the Slovak Republic

Coordination plays an important role in solving complex physical activities which arise during a biathlon race. We determined the level of coordination skills by measuring the time of a simple reaction to visual stimulus at rest by measuring the time response of complex reaction to visual stimuli by measuring the effect of visual-motor coordination (part of orientation skills - test Piórkowski) and by measuring the effect of visual-motor coordination (part of orientation skills - test Krzyżowy). In addition, we conducted a test of the simple and complex reaction after a short-term and long-term exercise. Among the tested sportswomen, the best results, both at rest and after exercise, have achieved twos Slovak athletes. Both results were above-average and slightly above-average. In order to develop physical coordination, we recommend biathletes to execute: the already known workout in different environmental conditions, while practicing new coordination exercises especially systematics not focusing on their maximum improvement but to gain general skills for practice while implementing them in the first part of the training

Level of biathlete coordination skills of biathletes: Representatives of the Slovak Republic

Coordination plays an important role in solving complex physical activities which arise during a biathlon race. We determined the level of coordination skills by measuring the time of a simple reaction to visual stimulus at rest by measuring the time response of complex reaction to visual stimuli by measuring the effect of visual-motor coordination (part of orientation skills - test Piórkowski) and by measuring the effect of visual-motor coordination (part of orientation skills - test Krzyżowy). In addition, we conducted a test of the simple and complex reaction after a short-term and long-term exercise. Among the tested sportswomen, the best results, both at rest and after exercise, have achieved twos Slovak athletes. Both results were above-average and slightly above-average. In order to develop physical coordination, we recommend biathletes to execute: the already known workout in different environmental conditions, while practicing new coordination exercises especially systematics not focusing on their maximum improvement but to gain general skills for practice while implementing them in the first part of the training