2 research outputs found
Impact of electrolyzed water applied as an alternative treatment in vineyard on grape and wine quality.
AIRE gene polymorphisms in systemic sclerosis associated with autoimmune thyroiditis
Mutations in the autoimmune regulator (AIRE) gene are responsible for autoimmune
polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy (APECED). Systemic sclerosis (SSc) is a
non-organ-specific autoimmune disease mainly characterized by cutaneous involvement, that is
frequently associated with other autoimmune manifestations common to APECED.
Nineteen SSc patients, 22 patients affected by SSc associated with autoimmune thyroiditis,
and 100 healthy controls were analyzed. We identified 11 AIRE gene variants, one of which has
never previously been described. Intronic polymorphism G11107A was significantly correlated to
SSc/thyroiditis. Data show that variants of the AIRE gene might be correlated to different clinical
manifestations in SSc patients