18 research outputs found
A sustained-release drug-delivery system of synthetic prostacyclin agonist, ONO-1301SR: a new reagent to enhance cardiac tissue salvage and/or regeneration in the damaged heart
Serum neutrophil gelatinase-associated lipocalin has an advantage over serum cystatin C and glomerular filtration rate in prediction of adverse cardiovascular outcome in patients with ST-segment elevation myocardial infarction
Maximumrenal responses to renin inhibition in healthy study participants: VTP-27999 versus aliskiren
Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial
Coronary Artery Spasm Related to Thiol Oxidation and Senescence Marker Protein-30 in Aging
Readmissions Rates After Myocardial Infarction for Gastrointestinal Bleeding: A National Perspective
How should I treat this unusual anterolateral ST-elevation myocardial infarction with recurrent ventricular fibrillation and cardiac arrest?
Percutaneous treatment of spontaneous left main coronary artery dissection using drug-eluting stent
Genetic variants of complement factor H gene are not associated with premature coronary heart disease:A family-based study in the Irish population
<p>Abstract</p> <p>Background</p> <p>The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease.</p> <p>Methods</p> <p>We evaluated 6 SNPs and 5 common haplotypes in the CFH gene amongst 1494 individuals in 580 Irish families with at least one member prematurely affected with coronary heart disease. Genotypes were determined by multiplex SNaPshot technology.</p> <p>Results</p> <p>Using the TDT/S-TDT test, we did not find an association between any of the individual SNPs or any of the 5 haplotypes and early-onset coronary heart disease.</p> <p>Conclusion</p> <p>In this family-based study, we found no association between the CFH gene and early-onset coronary heart disease.</p