17,842 research outputs found
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Human Activity Modelling in the Specification of Operational Requirements: Work in Progress
This paper describes our experience of integrating HCI concepts and techniques into a concurrent requirements engineering process called RESCUE. We focus on the use of a model of current human activity to inform specification of a future system. We show how human activity descriptions, written using a specially designed template, can facilitate the authoring of use case descriptions to be used in the elicitation of requirements for complex socio-technical systems. We describe our experience of using descriptions of human activity, written using the template, to support specification of operational requirements for DMAN, a system to support air traffic controllers in managing the departure of aircraft from airports. We end with a discussion of lessons learnt from our experience and present some ideas for future development of work in this area
Welfare Reform and Immigrant Participation in the Supplemental Security Income Program
We examine the effect of the 1996 welfare reform legislation on participation in the Supplemental Security Income (SSI) program by immigrants. Although none of the immigrants on the SSI rolls before welfare reform lost eligibility, the potential exists for future impacts on the SSI caseload and the well-being of recent immigrants. We use microdata files from the Social Security Administration’s Continuous Work History Sample matched to administrative data on SSI participation for the period 1993 to 1999. We estimate simple models of SSI participation and compare our results to the existing literature. We then estimate a series of difference-in-differences models of SSI participation. These models compare SSI participation by immigrants relative to nativeborn individuals, and among affected immigrants relative to unaffected immigrants and native-born individuals, before and after welfare reform. Descriptive results indicate that the percentage of immigrants and natives receiving SSI decreased after welfare reform, but by a larger percentage for natives than for immigrants. The probability of SSI participation decreased after welfare reform for immigrants who were affected by the legislation relative to immigrants who were unaffected. The difference-in-differences estimate is positive for immigrants relative to otherwise similar natives, but the estimated effect among affected immigrants is about half as large as the effect for unaffected immigrants. When the sample is limited to low earners as a proxy for the SSI means test, the results are qualitatively unchanged but quantitatively much stronger. Authors’ Acknowledgements We are grateful to Ulyses Balderas for assisting with the collection of some data used here. A previous version of this paper was presented at the 2004 Western Regional Science Association Annual Meeting, February 25-28, 2004, Maui, HI.
Efficient Investment in Children
Many would say that children are society's most precious resource. So, how should we invest in them? To gain insight into this question, a dynamic general equilibrium model is developed where children differ by ability. Parents invest time and money in their offspring, depending on their altruism. This allows their children to grow up as more productive adults. First, the efficient allocation is characterized. Next, this is compared with the outcome that arises when financial markets are incomplete. The situation where child-care markets are also lacking is then examined. Additionally, the consequences of impure altruism are analyzed.Investment in children; efficiency; imperfect financial markets; impure altruism; lack of child-care markets.
Efficient investment in children
Many would say that children are society’s most precious resource. So, how should it invest in them? To gain insight into this question, a dynamic general equilibrium model is developed where children differ by ability. Parents invest time and money in their offspring, depending on their altruism. This allows their children to grow up as more productive adults. First, the efficient allocation for the framework is characterized. Next, this is compared with the case of incomplete financial markets. Then, the situation where childcare markets are also lacking is examined. Additionally, the effects of impure altruism are analyzed.Econometric models
Efficient investment in children
If children are society’s most precious resource, as many would argue, how should we invest in them? To gain insight into this question, the authors develop a dynamic, general-equilibrium model in which children differ by ability. Parents invest time and money in their offspring, depending on their altruism, to help them grow into more productive adults. The authors characterize the efficient allocation, then compare it with the outcome that arises when financial markets are incomplete. They also examine the situation where childcare markets are lacking and analyze the consequences of impure altruism.
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FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour
<p>Abstract</p> <p>Background</p> <p>Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly affects the behaviour of the choroid plexus epithelium (CPe). The purpose of this study was to investigate expression of Fgf2 in rodent and human developing CPe and possible function of Fgf2, using <it>in vitro </it>models. The application of Fgf2 to brain <it>in vivo </it>can affect the whole tissue, making it difficult to assess specific responses of the CPe.</p> <p>Methods</p> <p>Expression of Fgf2 was studied by immunohistochemistry in rodent and human embryonic choroid plexus. Effects of Fgf2 on growth, secretion, aggregation and gene expression was investigated using rodent CPe vesicles, a three-dimensional polarized culture model that closely mimics CPe properties <it>in vivo</it>, and rodent CPe monolayer cultures.</p> <p>Results</p> <p>Fgf2 was present early in development of the choroid plexus both in mouse and human, suggesting the importance of this ligand in Fgf signalling in the developing choroid plexus. Parallel analysis of Fgf2 expression and cell proliferation during CP development suggests that Fgf2 is not involved in CPe proliferation <it>in vivo</it>. Consistent with this observation is the failure of Fgf2 to increase proliferation in the tri-dimensional vesicle culture model. The CPe however, can respond to Fgf2 treatment, as the diameter of CPe vesicles is significantly increased by treatment with this growth factor. We show that this is due to an increase in cell aggregation during vesicle formation rather than increased secretion into the vesicle lumen. Finally, Fgf2 regulates expression of the CPe-associated transcription factors, <it>Foxj1 </it>and <it>E2f5</it>, whereas transthyretin, a marker of secretory activity, is not affected by Fgf2 treatment.</p> <p>Conclusion</p> <p>Fgf2 expression early in the development of both human and rodent choroid plexus, and its ability to modulate behaviour and gene expression in CPe, supports the view that Fgf signalling plays a role in the maintenance of integrity and function of this specialized epithelium, and that this role is conserved between rodents and humans.</p
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Is UV laser ablation a suitable tool for geochemical analysis of organic rich source materials?
Abstract not available
Development of a mechatronic sorting system for removing contaminants from wool
Automated visual inspection (AVI) systems have been
extended to many fields, such as agriculture and the food, plastic
and textile industries. Generally, most visual systems only inspect
product defects, and then analyze and grade them due to the lack
of any sorting function. This main reason rests with the difficulty of
using the image data in real time. However, it is increasingly important
to either sort good products from bad or grade products into
separate groups usingAVI systems. This article describes the development
of a mechatronic sorting system and its integration with a
vision system for automatically removing contaminants from wool
in real time. The integration is implemented by a personal computer,
which continuously processes live images under the Windows
2000 operating system. The developed real-time sorting approach
is also applicable to many other AVI systems
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Potential of short wavelength laser ablation of organic materials
Although the literature contains several articles on UV laser ablation of synthetic polymers [1] and human tissue for surgical applications, to our knowledge there is no published record on organic geochemical applications for UV laser pyrolysis–gas chromatography–mass spectrometry (LA-GC-MS). In this study we have demonstrated the use of a 213 nm UV laser beam for ablating kerogens and organic rich rocks to liberate and analyse hydrocarbon signatures and compared the results against IR laser pyrolysis and traditional Py-GC-MS. It is possible to equate laser wavelength to electron volts where 1064 nm (IR) = 1.2 eV and 213 nm (UV) = 5.8 eV. Most chemical bonds have an energy between 2-4 eV and C-C bonds are ~3.6 eV. Organic materials can absorb radiation from a UV laser and chemical bonds can be cleaved cleanly by complex photochemical pathways by a single photon [2]. Ablation occurs with almost no heating of the sample and hence the term laser ablation instead of pyrolysis. Visible or IR lasers have insufficient energy to break bonds with a single photon this results in the heating of sample by the absobtion of energy into the vibrational modes of the molecule which can then result in pyrolysis. A solvent-extracted kerogen consisting mainly of higher plant material (Brownie Butte, Montanna, ~ 70 Ma) was used for initial experiments. A number of other samples have also been analysed. Laser ablation work was performed off-line in a static helium cell followed by solvent extraction of the laser cell. Separate analysis of the same samples using a more traditional flash pyrolysis approach was performed with a CDS pyroprobe and IR laser pyrolysis [3] for comparative purposes. As can be seen in Fig 1 UV laser ablation is able to liberate relatively high molecular weight fragments with no alkenes or other pyrolysis artefacts detected. SEM images of ablation pits indicate there is no obvious thermal alteration of the sample. The results of the pyrolysis techniques (on-line and IR laser pyrolysis) are similar and display a number of artefacts related to the pyrolysis process. Laser ablation of a number of samples has also shown that the distributions of biomarkers are comparable with the solvent extracts. Product yields although not quantified appear to be much higher than traditional pyrolysis technique
Collaborative Research: Developing Methods to Study Age-Related Changes in the Physiology of Forest Trees
Trees continue to increase in size and complexity over life spans that may last many centuries, and each year the growing regions of their shoots produce new foliage and reproductive structures. As they grow older and larger, forest trees appear to grow more slowly, produce thicker foliage and more reproductive structures. These changes are likely to be associated with age-related declines in the growth rates of forest stands, which occur before the mid-point of the lifespan of important timber species. Although similar patterns of age- and size-related change in the morphology and physiology of foliage have been described for numerous species, the mechanisms governing these changes are virtually unknown. Possible explanations for these phenomena range from decreased photosynthesis due to increased resistance of water flow to a genetically controlled ageing process that slows growth and photosynthesis. Processes regulating maturation, ageing and senescence are fundamental to biology, and some of these processes are probably unique to large, long-lived trees. A more complete understanding of the basis for this decline is necessary to model and accurately predict the growth of forests over time.Reciprocal grafting of shoots between trees of different ages offers great potential as a tool to distinguish among explanations for changes in growth behavior. In this approach, shoots from old growth trees are grafted onto juvenile and young-mature trees, and shoots from juvenile and young-mature trees are grafted into the crowns of old-growth trees. The extent, direction and time-course of changes in the growth, morphology, and physiology of foliage produced by the grafted shoots will provide insight into the mechanisms governing age-related change. This study will attempt reciprocal grafting on two species of long-lived trees, red spruce and Douglas fir. These species are adapted to substantially different climatic regimes, so a comparative study will provide insights into the universality or variability of processes associated with age-related changes in tree growth
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