14 research outputs found
Phylogenomic and functional analyses of salmon lice aquaporins uncover the molecular diversity of the superfamily in Arthropoda
Mercury content in the fur of jaguars (Panthera onca) from two areas under different levels of gold mining impact in the Brazilian Pantanal
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
The developmental, molecular, and transport biology of Malpighian tubules
Molecular biology is reaching new depths in our understanding of the development and physiology of Malpighian tubules. In Diptera, Malpighian tubules derive from ectodermal cells that evaginate from the primitive hindgut and subsequently undergo a sequence of orderly events that culminates in an active excretory organ by the time the larva takes its first meal. Thereafter, the tubules enlarge by cell growth. Just as modern experimental strategies have illuminated the development of tubules, genomic, transcriptomic, and proteomic studies have uncovered new tubule functions that serve immune defenses and the breakdown and renal clearance of toxic substances. Moreover, genes associated with specific diseases in humans are also found in flies, some of which, astonishingly, express similar pathophenotypes. However, classical experimental approaches continue to show their worth by distinguishing between -omic possibilities and physiological reality while providing further detail about the rapid regulation of the transport pathway through septate junctions and the reversible assembly of proton pumps
Aquaporins: Multiple roles in the central nervous system
Copyright © 2007 SAGE PublicationsAquaporins (AQPs) represent a diverse family of membrane proteins found in prokaryotes and eukaryotes. The primary aquaporins expressed in the mammalian brain are AQP1, which is densely packed in choroid plexus cells lining the ventricles, and AQP4, which is abundant in astrocytes and concentrated especially in the end-feet structures that surround capillaries throughout the brain and are present in glia limitans structures, notably in osmosensory areas such the supraoptic nucleus. Water movement in brain tissues is carefully regulated from the micro- to macroscopic levels, with aquaporins serving key roles as multifunctional elements of complex signaling assemblies. Intriguing possibilities suggest links for AQP1 in Alzheimer's disease, AQP4 as a target for therapy in brain edema, and a possible contribution of AQP9 in Parkinson's disease. For all the aquaporins, new contributions to physiological functions are likely to continue to be discovered with ongoing work in this rapidly expanding field of research.Andrea J. Yoo
Invertebrate aquaporins: a review
Ewan M. Campbell, Andrew Ball, Stefan Hoppler, Alan S. Bowma