14 research outputs found
Exploring the agreement between questionnaire information and DSM-IV diagnoses of comorbid psychopathology in children with autism spectrum disorders
Brief Report: DSM-5 âLevels of Support:â A Comment on Discrepant Conceptualizations of Severity in ASD
Long-Term Cognitive and Functional Outcomes in Children with Mucopolysaccharidosis (MPS)-IH (Hurler Syndrome) Treated with Hematopoietic Cell Transplantation
Neuropsychological and internalizing problems in acute central nervous system infections: a 1 year follow-up
Therapeutisches Vorgehen bei sensorischer Modulationsstörung (SMD): Ăberlegungen zur Befundung und Behandlung
Disrupted Stimulus Control But Not Reward Sensitivity in Individuals with Autism Spectrum Disorders: A Matching Law Analysis
Long-Term Cognitive and Behavioral Outcomes following Resolution of Sleep Disordered Breathing in Preschool Children
Clinical manifestations in children and adolescents with corpus callosum abnormalities
Corpus callosum abnormality (CCA) outcomes are quite unpredictable and variable, from asymptomatic forms to mild or severe neurodevelopment disorders. The aim of this study was to examine clinical outcomes in CCA patients. The study included 61 children and adolescents in whom brain magnetic resonance imaging (MRI) scans showed CCA, isolated or associated to other central nervous system lesions. All patients underwent anamnesis, physical and neurological examination, routine laboratory tests, electroencephalogram (EEG), and MRI scans. In all participants, the intelligence quotient (IQ) was determined. We divided the participants into two subgroups: the first subgroup included patients with an isolated CCA, and the second subgroup included patients with CCA associated with extra-callosal brain lesions (complex CCA). We found that CCA were associated with elevated frequency to intellectual disability (ID), other neurodevelopment disorders, epilepsy, and isolated EEG anomalies. Mild ID (pĂÂ =ĂÂ 0.003) was more frequent in the isolated subgroup, while epilepsy (pĂÂ =ĂÂ 0.036) and pre-perinatal risk factors (pĂÂ =ĂÂ 0.023) were more frequent in the complex CCA subgroup. Although the role of the CC in the interhemispheric communication is known, neurological and neurodevelopment outcomes of CCA are extremely variable and unpredictable. The presence of extra-callosal brain anomalies is one of the major prognostic factor, and probably, they have an important impact on the clinical outcome