3 research outputs found
3′ end mRNA processing: molecular mechanisms and implications for health and disease
- Author
- Adamson TE
- Adamson TE
- Ahn SH
- Alt FW
- Ambros V
- Andreas E Kulozik
- Awasthi S
- Balim Z
- Ballantyne S
- Barabino SM
- Barreau C
- Barth ML
- Bell DA
- Bennett CL
- Bensen JT
- Bishop DF
- Black DL
- Black DL
- Bonapace G
- Brackenridge S
- Brais B
- Brown KM
- Buratowski S
- Calado A
- Calin GA
- Calzado MA
- Ceelie H
- Chen F
- Chen JM
- Chen JM
- Chen Q
- Chen Z
- Chuvpilo S
- Cohen SM
- Colgan DF
- Colgan DF
- Colgan DF
- Colot HV
- Cools J
- Cosson B
- Cox DG
- Croce CM
- Cushley W
- Danckwardt S
- Danckwardt S
- Danckwardt S
- Danckwardt S
- Davies JE
- Dominski Z
- Early P
- Edmonds M
- Edwalds-Gilbert G
- Feng L
- Fortes P
- Furth PA
- Gawande B
- Gehring NH
- Getz MJ
- Gieselmann V
- Gilat R
- Gilmartin GM
- Gilmartin GM
- Giraldez AJ
- Graveley BR
- Graveley BR
- Gunderson SI
- Gunderson SI
- Gunderson SI
- Hall-Pogar T
- Hall-Pogar T
- Hampsey M
- Harteveld CL
- Harvey J
- He L
- Hennig BJ
- Hentze MW
- Higgs DR
- Hirose Y
- Hirose Y
- Hirsh J
- Holbrook JA
- Honda H
- Hsu AP
- Hu J
- Jacob ST
- Jankovic L
- Kahvejian A
- Kaneko S
- Kastan MB
- Kaufmann I
- Keller W
- Kim YJ
- Kioka T
- Kleiman FE
- Kleiman FE
- Kobayashi K
- Kolev NG
- Kuhn U
- Kuroki K
- Kuwahara M
- Kyburz A
- Lambert J-C
- Lazarowitz SG
- Legendre M
- Legendre M
- Lewis JD
- Li X
- Li Y
- Lopez AJ
- Lou H
- Lu J
- Lu Y
- Lukiw WJ
- Lutz CS
- Mandel CR
- Mangus DA
- Maniatis T
- Maniatis T
- Maquat LE
- Martincic K
- Marzluff WF
- Marzluff WF
- Matthias W Hentze
- McCracken S
- McCracken S
- McGregor F
- McLauchlan J
- McLauchlan J
- Millevoi S
- Millevoi S
- Minvielle-Sebastia L
- Moreira A
- Moreira A
- Murthy KG
- Natalizio BJ
- Nemeroff ME
- Neu-Yilik G
- Niwa M
- O&apos
- Orkin SH
- Pan SS
- Pandey NB
- Pangalis GA
- Pendurthi UR
- Phillips C
- Phillips C
- Pizzuti A
- Poort SR
- Proudfoot N
- Proudfoot NJ
- Rao P
- Reed R
- Ristimaki A
- Rogers J
- Rosonina E
- Rund D
- Ryan K
- Sachs AB
- Sandri-Goldin RM
- Sasaki R
- Schambach A
- Schrijver I
- Schwartz E
- Scorilas A
- Scorilas A
- Seegers D
- Shell SA
- Shin C
- Shin HD
- Shyu A-B
- Soo PY
- Stark A
- Stetler DA
- Stetler DA
- Stoehlmacher J
- Strathdee CA
- Stutz F
- Sven Danckwardt
- Takagaki Y
- Takagaki Y
- Tian B
- Topalian SL
- Trangas T
- Uitte de Willige S
- Uitte de Willige S
- Vagner S
- Valsamakis A
- van Solinge WW
- Venkataraman K
- Veraldi KL
- von Lindern M
- Wahle E
- Wassarman KM
- Weatherall DJ
- Weiner AM
- Wilson T
- Xie X
- Yan J
- Yasuda M
- Zaiss A-K
- Zhang J
- Zhang Z
- Zhao J
- Zhao W
- Zheng SL
- Zhu H
- Zhu H
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Recent advances in the understanding of the molecular mechanism of mRNA 3′ end processing have uncovered a previously unanticipated integrated network of transcriptional and RNA-processing mechanisms. A variety of human diseases impressively reflect the importance of the precision of the complex 3′ end-processing machinery and gene specific deregulation of 3′ end processing can result from mutations of RNA sequence elements that bind key specific processing factors. Interestingly, more general deregulation of 3′ end processing can be caused either by mutations of these processing factors or by the disturbance of the well-coordinated equilibrium between these factors. From a medical perspective, both loss of function and gain of function can be functionally relevant, and an increasing number of different disease entities exemplifies that inappropriate 3′ end formation of human mRNAs can have a tremendous impact on health and disease. Here, we review the mechanistic hallmarks of mRNA 3′ end processing, highlight the medical relevance of deregulation of this important step of mRNA maturation and illustrate the implications for diagnostic and therapeutic strategies
Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end
- Author
- A Calado
- A Castello
- A Decorsière
- A Derti
- A Kahvejian
- A Kalsotra
- A Kyburz
- A Lembo
- A Moreira
- A Moreira
- A Rehfeld
- A Sachs
- A Wiestner
- AB Sachs
- AJ Matlin
- AJ Shatkin
- AJ Wood
- AM Weiner
- Anton Ogorodnikov
- AR Gruber
- AR Morris
- B Brais
- B Lackford
- B Tian
- B Tian
- BD Berkovits
- BH Akman
- BJ Blencowe
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- BT Wilhelm
- C Hornyik
- C Mayr
- C Phillips
- C Phillips
- CC MacDonald
- CH Jan
- CJ David
- CK Mapendano
- CL Bennett
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- DF Colgan
- DL Black
- DR Higgs
- DSC Graham
- E Beaudoing
- E Klerk de
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- E Rosonina
- E Wahle
- ET Wang
- F Chen
- F Ozsolak
- F Stutz
- FE Kleiman
- FW Alt
- G Edwalds-Gilbert
- G Martin
- G-S Wang
- G-Y Liao
- GM Gilmartin
- H Chang
- H Lou
- H Zhang
- I Hollerer
- I Jonkers
- I Kaufmann
- I Schrijver
- J Cools
- J Hu
- J Langemeier
- J McLauchlan
- J McLauchlan
- J Rogers
- J Yan
- J Zhao
- JE Wilusz
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- K Fox-Walsh
- K Martincic
- K Ryan
- K Venkataraman
- K Xiang
- KL Veraldi
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- KM Wassarman
- L Blázquez
- L Feng
- L Schonemann
- L Wang
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- M Dutertre
- M Hampsey
- M Hoque
- M Jenal
- M Legendre
- M Mangone
- M Niwa
- ME Nemeroff
- MG Berg
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- P Early
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- R Reed
- R Sandberg
- R Soetanto
- RK Singh
- RM Sandri-Goldin
- RR Graham
- S Awasthi
- S Brackenridge
- S Buratowski
- S Chuvpilo
- S Danckwardt
- S Danckwardt
- S Danckwardt
- S Danckwardt
- S Danckwardt
- S Danckwardt
- S Kaneko
- S McCracken
- S Millevoi
- S Millevoi
- S Millevoi
- S Vagner
- S Vorlova
- S Wilkening
- SA Shell
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- SG Lazarowitz
- SH Ahn
- SH Orkin
- SI Gunderson
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- Z Balim
- Z Chen
- Z Dominski
- Z Ji
- Z Ji
- Z Lian
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Modeling
- Author
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- A Baranyi
- A Baranyi
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- A Berman
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- A Goldenblum
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- WH Dierking
- WH Kent
- WJ Louw
- WJL McCready
- WK Woo
- WL Engl
- WR Schroeder
- WT Coston
- WW Togatoff
- Y Daimon
- Y Hayashi
- Y Hayashi
- Y Hirachi
- Y Matsumoto
- Y Tsuboi
- YA El-Mansy
- YC Cheng
- YL Kuo
- Z Berka
- Z Lukes
- Z Stefankiewicz
- Z Zilka
- Z Zilka
- Z Zilka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1976
- Field of study