P019. Transcutaneous supraorbital neurostimulation in “de novo” patients with migraine without aura: the first Italian experience

Transcutaneous supraorbital neurostimulation (tSNS) has been recently found superior to sham stimulation for episodic migraine prevention in a randomized trial. We evaluated both the safety and efficacy of a brief period of tSNS in a group of patients with migraine without aura (MwoA)

Substrate reduction therapy with Miglustat in pediatric patients with GM1 type 2 gangliosidosis delays neurological involvement: A multicenter experience

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A transient third cranial nerve palsy as presenting sign of spontaneous intracranial hypotension

Spontaneous intracranial hypotension is an uncommon cause of sudden and persistent headache: associated symptoms are common, among which there are cranial nerve palsies, especially of the abducens nerve. We report a case of a 21-year-old man with a transient and isolated third nerve palsy due to spontaneous intracranial hypotension. To our knowledge, there are only few reports in the literature of such association

Correlates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease

Abstract: Background: Subjective complaints of cognitive deficits are not necessarily consistent with objective evidence of cognitive impairment in Parkinson’s disease (PD). Here we examined the factors associated with the objective-subjective cognitive discrepancy. Methods: We consecutively enrolled 90 non-demented patients with PD who completed the Parkinson’s Disease Cognitive Functional Rating Scale (subjective cognitive measure) and the Montreal Cognitive Assessment (MoCA; objective cognitive measure). The patients were classified as “Overestimators”, “Accurate estimators”, and “Underestimators” on the basis of the discrepancy between the objective vs. subjective cognitive measures. To identify the factors distinguishing these groups from each other, we used chi-square tests or one-way analyses of variance, completed by logistic and linear regression analyses. Results: Forty-nine patients (54.45%) were classified as “Accurate estimators”, 29 (32.22%) as “Underestimators”, and 12 (13.33%) as “Overestimators”. Relative to the other groups, the “Underestimators” scored higher on the Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), and Parkinson Anxiety Scale (p < 0.01). Logistic regression confirmed that FSS and BDI scores distinguished the “Underestimators” group from the others (p < 0.05). Linear regression analyses also indicated that FSS and BDI scores positively related to objective-subjective cognitive discrepancy (p < 0.01). “Overestimators” scored lower than other groups on the MoCA’s total score and attention and working memory subscores (p < 0.01). Conclusion: In more than 45% of consecutive non-demented patients with PD, we found a ‘mismatch’ between objective and subjective measures of cognitive functioning. Such discrepancy, which was related to the presence of fatigue and depressive symptoms and frontal executive impairments, should be carefully evaluated in clinical setting

Pyridine vapors detection by an optical fibre sensor

An optical fibre sensor has been implemented towards pyridine vapors detection;to achieve this, a novel vapochromic material has been used, which, in solid state, suffers achange in colour from blue to pink-white in presence of pyridine vapours. This complex isadded to a solution of PVC (Poly Vinyl Chloride), TBP (Tributylphosphate) andtetrahydrofuran (THF), forming a plasticized matrix; by dip coating technique, the sensingmaterial is fixed onto a cleaved ended optical fibre. The fabrication process was optimizedin terms of number of dips and dipping speed, evaluating the final devices by dynamicrange. Employing a reflection set up, the absorbance spectra and changes in the reflectedoptical power of the sensors were registered to determine their response. A linear relationbetween optical power versus vapor concentration was obtained, with a detection limit of 1ppm (v/v).Financial support from the Spanish Comisión Interministerial de Ciencia y Tecnología within projects TEC2006-12170/MIC, TEC2004-05936-C02-01/MIC, BQU2001-3221, CTQ2005-09023 and Project of Excellence RNM666 de la Junta de Andalucía, is acknowledged

Ciudades biodiversas: mamíferos medianos de la Reserva Forestal Protectora Bosque Oriental de Bogotá D. C., Colombia

In this contribution, we present an updated list of medium-sized mammals present in the Bosque Oriental Protective Forest Reserve of Bogotá. The study area includes the Bogotá Bosque Oriental Protective Forest Reserve that is located east of the city of Bogotá D.C., and commonly known as Eastern Hills.En esta contribución, presentamos un listado actualizado de los mamíferos medianos presentes en la Reserva Forestal Protectora Bosque Oriental de Bogotá. El área de estudio comprende la Reserva Forestal Protectora Bosque Oriental de Bogotá que se localiza al oriente de la ciudad de Bogotá D.C., y comúnmente conocida como Cerros Orientales

Maquina Verde - El Arca Solar Decathlon Latin America & Caribbean 2019

The current supply of social housing in Latin American countries is often not adequate for the real needs of the population, generating situations of social conflict and permanent contraposition between the “formal” and the “informal” cities. The Pontificia Universidad Javeriana of Bogotá and the Politecnico di Torino participated together in the Solar Decathlon Latin America and Caribbean 2019 competition with the project Máquina Ver-de - El Arca, a vivienda social thought for the informal neighborhood of El Pozón, located in the periphery of the Colombian city of Cartagena de Indias. The project is based on the reinterpretation of the Caribbean house, starting from a study of the user needs, integrating industrial technologies - like the steel frame- and artisanal technologies -such as the tejidos in the façade-, with a strategy to reduce the environmental impact of the building in its life cycle. In December 2019 Máquina Verde - El Arca was built and tested by the students and professors of the two universities during the final phase of the Solar Decathlon in Cali, Colombia. The collaboration in the international competition was born as an innovative training activity based on PBL (Problem Based Learning) and “learning by doing” methodologies and has evolved into a shared research about the issues of environmental, social and economic sustainability for the architecture of social interest of the Latin American cities

Migration Restrictions and Criminal Behavior: Evidence from a Natural Experiment *

Abstract We estimate the causal effect of immigrants&apos; legal status on criminal behavior exploiting exogenous variation in migration restrictions across nationalities driven by the last round of the European Union (EU) enlargement. Unique individual-level data on a collective clemency bill enacted in Italy five months before the enlargement allow us to compare the post-release criminal record of inmates from new EU member countries with a control group of pardoned inmates from candidate EU member countries. Differences in differences in the probability of rearrest between the two groups before and after the enlargement show that obtaining legal status lowers the recidivism of economically motivated offenders, but only in areas that provide relatively better labor market opportunities to legal immigrants. We provide a search-theoretic model of criminal behavior that is consistent with these results

A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study

Background Sex is a major source of diversity among patients and a sex-informed approach is becoming a new paradigm in precision medicine. We aimed to describe sex diversity in myelodysplastic syndromes in terms of disease genotype, phenotype, and clinical outcome. Moreover, we sought to incorporate sex information into the clinical decision-making process as a fundamental component of patient individuality. Methods In this multicentre, observational cohort study, we retrospectively analysed 13 284 patients aged 18 years or older with a diagnosis of myelodysplastic syndrome according to 2016 WHO criteria included in the EuroMDS network (n=2025), International Working Group for Prognosis in MDS (IWG-PM; n=2387), the Spanish Group of Myelodysplastic Syndromes registry (GESMD; n=7687), or the Dusseldorf MDS registry (n=1185). Recruitment periods for these cohorts were between 1990 and 2016. The correlation between sex and genomic features was analysed in the EuroMDS cohort and validated in the IWG-PM cohort. The effect of sex on clinical outcome, with overall survival as the main endpoint, was analysed in the EuroMDS population and validated in the other three cohorts. Finally, novel prognostic models incorporating sex and genomic information were built and validated, and compared to the widely used revised International Prognostic Scoring System (IPSS-R). This study is registered with ClinicalTrials.gov, NCT04889729. Findings The study included 7792 (58middot7%) men and 5492 (41middot3%) women. 10 906 (82middot1%) patients were White, and race was not reported for 2378 (17middot9%) patients. Sex biases were observed at the single-gene level with mutations in seven genes enriched in men (ASXL1, SRSF2, and ZRSR2 p<0middot0001 in both cohorts; DDX41 not available in the EuroMDS cohort vs p=0middot0062 in the IWG-PM cohort; IDH2 p<0middot0001 in EuroMDS vs p=0middot042 in IWG-PM; TET2 p=0middot031 vs p=0middot035; U2AF1 p=0middot033 vs p<0middot0001) and mutations in two genes were enriched in women (DNMT3A p<0middot0001 in EuroMDS vs p=0middot011 in IWG-PM; TP53 p=0middot030 vs p=0middot037). Additionally, sex biases were observed in co-mutational pathways of founding genomic lesions (splicing-related genes, predominantly in men, p<0middot0001 in both the EuroMDS and IWG-PM cohorts), in DNA methylation (predominantly in men, p=0middot046 in EuroMDS vs p<0middot0001 in IWG-PM), and TP53 mutational pathways (predominantly in women, p=0middot0073 in EuroMDS vs p<0middot0001 in IWG-PM). In the retrospective EuroMDS cohort, men had worse median overall survival (81middot3 months, 95% CI 70middot4-95middot0 in men vs 123middot5 months, 104middot5-127middot5 in women; hazard ratio [HR] 1middot40, 95% CI 1middot26-1middot52; p<0middot0001). This result was confirmed in the prospective validation cohorts (median overall survival was 54middot7 months, 95% CI 52middot4-59middot1 in men vs 74middot4 months, 69middot3-81middot2 in women; HR 1middot30, 95% CI 1middot23-1middot35; p<0middot0001 in the GEMSD MDS registry; 40middot0 months, 95% CI 33middot4-43middot7 in men vs 54middot2 months, 38middot6-63middot8 in women; HR 1middot23, 95% CI 1middot08-1middot36; p<0middot0001 in the Dusseldorf MDS registry). We developed new personalised prognostic tools that included sex information (the sex-informed prognostic scoring system and the sex-informed genomic scoring system). Sex maintained independent prognostic power in all prognostic systems; the highest performance was observed in the model that included both sex and genomic information. A five-to-five mapping between the IPSS-R and new score categories resulted in the re-stratification of 871 (43middot0%) of 2025 patients from the EuroMDS cohort and 1003 (42middot0%) of 2387 patients from the IWG-PM cohort by using the sex-informed prognostic scoring system, and of 1134 (56middot0%) patients from the EuroMDS cohort and 1265 (53middot0%) patients from the IWG-PM cohort by using the sex-informed genomic scoring system. We created a web portal that enables outcome predictions based on a sex-informed personalised approach. Interpretation Our results suggest that a sex-informed approach can improve the personalised decision making process in patients with myelodysplastic syndromes and should be considered in the design of clinical trials including low-risk patients. Copyright (c) 2022 Published by Elsevier Ltd. All rights reserved