8 research outputs found
A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling
- Author
- A Dityatev
- A Harada
- A Konar
- A Konar
- AG Almonte
- Alzheimer’s Association
- B Maloney
- B Ray
- CK Frese
- CM Alberini
- DJ Foster
- ER Kandel
- G Luksys
- GH Poplawski
- GM Yousef
- H Tamura
- I Pavlov
- K Matsumoto-Miyai
- K Nho
- KS Kosik
- L Dehmelt
- L Zhou
- M Kalinska
- N Djogo
- NA Bishop
- S Ortega-Martinez
- S Shiosaka
- T Abel
- Y Ishikawa
- Y Nakamura
- Y Nakamura
- YA Huang
- ZL Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fiscal Rules and the Sovereign Default Premium
- Author
- A Corbacho
- A Iara
- A R Ghosh
- A Schaechter
- C A V�gh
- C Arellano
- C Arellano
- C B Durdu
- C J Garcia
- C M Reinhart
- C Reinhart
- C Trebesch
- D A Dias
- D Benjamin
- D Pouzo
- D Pouzo
- E Boz
- E Ilzetzki
- E Mendoza
- E Pappa
- E Talvi
- E Tanner
- F Heinemann
- F Roch
- Francisco Roch
- G Adler
- G Calvo
- G Cuadra
- G Cuadra
- G Gelos
- G Kaminsky
- G Kopits
- G Lorenzoni
- G Sandleris
- H Bi
- H Bi
- I Livshits
- Imf
- Imf
- Imf
- Imf
- J Bianchi
- J C Hatchondo
- J C Hatchondo
- J C Hatchondo
- J C Hatchondo
- J C Hatchondo
- J Eaton
- J J Cruces
- J M Poterba
- J M Sanchez
- J P Medina
- J Poterba
- Juan Carlos Hatchondo
- K Athreya
- L P Feld
- Leonardo Martinez
- M Aguiar
- M Aguiar
- M Azzimonti
- M Azzimonti
- M Gavin
- M Poplawski Ribeiro
- N Budina
- O Blanchard
- O Blanchard
- P D&apos
- P Neumeyer
- R Beetsma
- R Beetsma
- R Lowry
- S Chatterjee
- S Chatterjee
- S Chatterjee
- S Claessens
- S Deroose
- S Lizarazo
- S Lizarazo
- V Yue
- W Li
- X Debrun
- X Debrun
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
L1CAM drives oncogenicity in esophageal squamous cell carcinoma by stimulation of ezrin transcription
- Author
- A Bechara
- A Subramanian
- AG Zeimet
- C Li
- Chun Sun
- D Gast
- D Gast
- E Donier
- En-Min Li
- FG Rathjen
- G Thor
- GH Poplawski
- H Kiefel
- H Kiefel
- H Kiefel
- H Kiefel
- HH Cao
- Hui-Hui Cao
- IC Gool Van
- J Clucas
- Jian-Jun Xie
- Jian-Yi Wu
- Jin-Cheng Guo
- JJ Xie
- JM Hilari
- K Reiss
- L Cheng
- Li-Qiang Ran
- Li-Yan Xu
- Lian-Di Liao
- LL Sun
- M Moos
- M Yang
- MA Henry
- Melitta Schachner
- MJ Domper Arnal
- N Gavert
- N Kulahin
- NP Rizk
- P Altevogt
- P Shannon
- PC Enzinger
- PF Maness
- Q Ben
- QW Ben
- R Gertler
- R Islam
- RS Schmid
- S Riedle
- S Scrace
- S Silletti
- SY Gao
- T Maretzky
- T Rawnaq
- V Castellani
- Wang-Kai Fang
- Wei-Jiang Zhao
- WH Allum
- XD Zhang
- Y Wang
- Yang-Min Xie
- Zhi-Yong Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish
- Author
- A Buffo
- A Irintchev
- AA Lavdas
- AA Lavdas
- C Hans
- C Romeo
- C Roonprapunt
- CD Witiw
- CG Becker
- D Lutz
- D Lutz
- DK Lahiri
- E Lundberg
- F Barnabé-Heider
- G Barbin
- G Loers
- G Loers
- Gabriele Loers
- GH Poplawski
- H Kamiguchi
- H Kataria
- H Mehta
- HJ Lee
- HQ Cao
- Huifan Shen
- J Chen
- J Chen
- J Karlsson
- J Schweitzer
- J Yang
- JC Xu
- JR Faulkner
- Junkai Hu
- K Matsumoto-Miyai
- K Nakamura
- KA Zukor
- KJ Livak
- M Lange
- M Racchi
- M Westerfield
- MA Winker
- ME Fabiani
- Melitta Schachner
- MJ Knapp
- ML Crismon
- MM Reimer
- N Djogo
- P Hulley
- PB Watkins
- PM Wood
- Q Tian
- R Brambilla
- R Deumens
- R Sousa Abreu de
- RJ Giger
- Rong Li
- RR Bernhardt
- RS Schmid
- S Chen
- SD Skaper
- Sudhanshu Sahu
- T Becker
- T Becker
- T Sugawara
- V Bracchi-Ricard
- V Castellani
- X He
- Y Goldshmit
- Y Guo
- Y Wang
- Yanqin Shen
- YM Yu
- Z Jiang
- ZG Zhong
- ZH Zhang
- Zhihua Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Hippocampal Gene Expression Meta-Analysis Identifies Aging and Age-Associated Spatial Learning Impairment (ASLI) Genes and Pathways
- Author
- A Alzheimer’s
- A Ramasamy
- A Sirbu
- AC Arnold
- B Sass
- BC Miller
- BM Bolstad
- C Burger
- C Burger
- C Chen
- C Glorioso
- C Glorioso
- C Li
- C Menard
- C O’Neill
- CR Bramham
- DR Rhodes
- DY Chen
- EA Finch
- EA Gay
- EH Corder
- EM Blalock
- F Borghese
- F Shen
- G Bu
- G Cazander
- GH Poplawski
- GK Smyth
- GL Coleman
- H Park
- HJ He
- I Kadish
- JD Shepherd
- JF Guzowski
- JF Lin
- JP Montmayeur
- JR Klune
- JS Ramsdell
- JT Leek
- K Bartus
- L Gautier
- M Angelo
- M Maier
- M Mihelic
- M Smogorzewski
- M Verbitsky
- MA Moscarello
- Manlio Vinciguerra
- MM Mesulam
- MP Daniels
- MP Mattson
- MS Wyeth
- N Burgess
- N Ishii
- N Plath
- NN Nalivaeva
- OA Timofeeva
- P Monfort
- P Poulin
- P Zwanzger
- PB Scotland
- PF Maness
- PW Landfield
- Q Xiao
- R Roesler
- R Romaniello
- Raihan K. Uddin
- RE Tanzi
- RG Morris
- RP Ebstein
- S Genoud
- S Kenwrick
- S Maeda
- S Peleg
- SA Small
- Shiva M. Singh
- T Derfuss
- T Lu
- T Osterwalder
- TC Foster
- TD Cushion
- TL Pawlowski
- TW Lee
- V Shukla
- WB Rowe
- WE Johnson
- Y Benjamini
- Y Moreau
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Cancer Type-Specific Epigenetic Changes: Gastric Cancer
- Author
- A Bellacosa
- A Fournier
- A Hishida
- A Jemal
- A Shiotani
- A Shiotani
- AJ Peterson
- AN Feng
- B Humar
- B Xiao
- B Xiao
- B Xiao
- B Zheng
- BG Zhang
- BH Kim
- BN Borges
- BN Borges
- C Belair
- C Sakakura
- CL Li
- CM Shin
- CM Shin
- CO Gigek
- CX Dong
- D Ben Ayed-Guerfali
- D Liu
- D Yao
- DH Ahn
- DQ Calcagno
- DQ Calcagno
- DQ Calcagno
- DQ Calcagno
- DQ Calcagno
- E Oki
- E Tahara
- EJ Cha
- F Carneiro
- F Gao
- F Ksiaa
- F Li
- F Song
- F Zhou
- G Tamura
- GH Cai
- GH Kang
- H Cai
- H Fan
- H Geddert
- H Iizasa
- H Kim
- H Lee
- H Lu
- H Luo
- H Shigaki
- H Sugita
- HG Kim
- HK Lim
- HY Wan
- J Christensen
- J Hu
- J Kurashige
- J Shi
- J Song
- J Song
- J Wang
- J Xiao
- J Yang
- J Zeng
- JG Kim
- JH Choi
- JH Choi
- JH Kim
- JH Liu
- JL Wang
- JM Bae
- JY Fang
- K Balassiano
- K Motoyama
- K Mutze
- K Mutze
- K Sakuraba
- K Sakurada
- KF Pan
- KH Lee
- KW Tsai
- L Cui
- L Feng
- L Liu
- L Lopez-Serra
- L Parry
- L Zhao
- L Zheng
- LH Guo
- LJ He
- M D'Errico
- M Ehrlich
- M Esteller
- M Hiraki
- M Hiraki
- M Iizuka
- M Murai
- M Okubo
- M Pinto
- M Sun
- M Tsujiura
- M Wang
- M Zhu
- MF Leal
- MS Al-Moundhri
- MS Kim
- MW Zhang
- MZ Ying
- N Koshiishi
- N Li
- N Lopez-Bigas
- N Oue
- N Sakamoto
- O Bogdanović
- O Tchernitsa
- OJ Sansom
- P Correa
- P Dikeakos
- P Lauren
- P Rotkrua
- PA Defossez
- Q Sun
- Q Yang
- Q Yang
- Q Yang
- Q Yao
- QM Yu
- R Feng
- R Garzon
- R Kogo
- R Wadhwa
- S Komatsu
- S Peng
- S Yamanaka
- SG Crone
- SH Lee
- SL Hu
- SR Ogden
- SY Kim
- T Bou Kheir
- T Inoue
- T Liu
- T Maekita
- T Otsubo
- T Poplawski
- T Sudo
- T Sun
- T Tahara
- T Ueda
- W Guo
- W Guo
- W Kang
- W Li
- W Li
- W Weichert
- WJ Ding
- WQ Kong
- X Li
- X Li
- X Li
- X Su
- XP Zou
- XW Zhang
- XX Lu
- XY Fan
- Y Baba
- Y Kanai
- Y Kanai
- Y Kang
- Y Matsukawa
- Y Oshimo
- Y Shigematsu
- Y Tokumaru
- Y Watanabe
- Y Xu
- Y Zeng
- Y Zheng
- Y Zhou
- Y Zhou
- Y Zhu
- YK Kim
- YM Zhu
- YW Lu
- Z Cao
- Z Chun-Zhi
- Z Guan
- Z Hou
- Z Hou
- Z Zhang
- ZQ Ling
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Microtubule Organization and Microtubule-Associated Proteins (MAPs)
- Author
- A Akhmanova
- A Akhmanova
- A Andrieux
- A Andrieux
- A Caceres
- A Caceres
- A Caceres
- A Caceres
- A Caceres
- A Caceres
- A Cheng
- A Daoust
- A Desai
- A Ebneth
- A Ebneth
- A Efimov
- A Fellous
- A Gupta
- A Harada
- A Harada
- A Ikeda
- A Kawachi
- A Kremer
- A Massow von
- A Matus
- A Matus
- A Meixner
- A Merenlender-Wagner
- A Migheli
- A Mori
- A Peck
- A Roll-Mecak
- A Samsonov
- A Seitz
- A Stewart
- A Takashima
- A Vandecandelaere
- AB Rocher
- AC Horton
- AC Kwan
- AG Leenders
- AJ Koleske
- AJ Scheetz
- AK Voss
- AR Kumarapeli
- AR Vaillant
- B Lacroix
- B Pedrotti
- B Pedrotti
- B Pedrotti
- B Pedrotti
- B Riederer
- B Riederer
- B Shafit-Zagardo
- B Trinczek
- B Ye
- B Ye
- BL Goode
- BM Paschal
- BM Paschal
- BM Schwenk
- BR Hoover
- C Bonnet
- C Bosc
- C Bosc
- C Bouquet
- C Bouvrais-Veret
- C Bouvrais-Veret
- C Clemmensen
- C Conde
- C Erck
- C Gonzalez-Billault
- C Gonzalez-Billault
- C Gonzalez-Billault
- C Gonzalez-Billault
- C Janke
- C Janke
- C Klein
- C Maas
- C Sanchez
- C Viereck
- CA Farah
- CC Cunningham
- CC Garner
- CC Garner
- CC Hoogenraad
- CC Wu
- CD Ochoa
- CE Walczak
- CP Samora
- CW Liu
- D Delotterie
- D Job
- D Job
- D Masson
- D Satoh
- D Terwel
- D Villarroel-Campos
- DA Dombeck
- DA Keays
- DA Vouyiouklis
- DG Drubin
- DJ Asai
- DJ Sharp
- DL Lev
- DL Moolman
- DM Loeb
- DN Drechsel
- DW Cleveland
- DW Cleveland
- E Allen
- E Capetillo-Zarate
- E Chevalier-Larsen
- E Denarier
- E Denarier
- E Fifkova
- E Kage
- E Shin
- E Sontag
- E Tortosa
- E Tortosa
- E Utreras
- EM Faller
- F Chee
- F Dou
- F Zalfa
- FE Poulain
- FE Poulain
- FJ Mattie
- FJ McNally
- G Cheng
- G Cheng
- G Davidkova
- G Dziewczapolski
- G Eot-Houllier
- G Gevorkian
- G Huber
- G Huber
- G Lansbergen
- G Lebeau
- G Lee
- G Liao
- G Paglini
- G Pigino
- G Rosoklija
- G Szebenyi
- G Wiche
- GE Karagoz
- GH Grossman
- GH Poplawski
- GJ Brouhard
- GJ Praefcke
- GS Bloom
- GS Bloom
- H Doodhi
- H Felgner
- H Fuhrmann-Stroissnigg
- H Liao
- H Sudo
- H Witte
- H Xiao
- H Zempel
- H Zempel
- HH Lee
- HH Sung
- HJ Yang
- HL Nguyen
- HL Nguyen
- HM Rubino
- HN Dawson
- I Fischer
- I Lajoie-Mazenc
- I Semenova
- J Al-Bassam
- J Avila
- J Avila
- J Baratier
- J Basbous
- J Bash-Babula
- J Baudier
- J Chen
- J Diaz-Nido
- J Diaz-Nido
- J Ding
- J Ding
- J Ding
- J Garcia-Perez
- J Gu
- J Howard
- J Huang
- J Jaworski
- J Lipka
- J Luders
- J Nunez
- J Peng
- J Sparacino
- J Teng
- J Yan
- J Yan
- J Zhang
- JA Morris
- JA Rio Del
- JB Olmsted
- JC Bulinski
- JC Bulinski
- JC Bulinski
- JC Bulinski
- JC Bulinski
- JC Kurz
- JE Brenman
- JM Saffin
- JM Sontag
- JR Kardon
- JS Albala
- JW Hammond
- JW Hammond
- JW Mandell
- K Barlan
- K Faire
- K Fujio
- K Hayashi
- K Jiang
- K Kajitani
- K Langnaese
- K Matsushima
- K Sobue
- K Stamer
- K Tokuraku
- K Tokuraku
- KA Johnson
- KE Burgin
- KJ Powell
- KJ Verhey
- KL Tucker
- KM Kollins
- KM Ori-McKenney
- KP McNally
- KR Olson
- KS Kosik
- KW Yau
- KW Yau
- KY Su
- L Chang
- L Cheng
- L Dehmelt
- L Dehmelt
- L Ferhat
- L Fontenille
- L Guillaud
- L Luo
- L Swiech
- L Ulloa
- L Ulloa
- L Ulloa
- LA Lopez
- LA Lopez
- LC Kapitein
- LC Kapitein
- LC Kapitein
- LI Binder
- LI Binder
- LM Griffith
- LM Ittner
- LM Parysek
- M Aguezzoul
- M Arrasate
- M Begou
- M Benoist
- M Bornens
- M Dubey
- M Eriksson
- M Garcia Rocha
- M Goedert
- M Gupta
- M Hasegawa
- M Hoshi
- M Kempf
- M Komada
- M Kuijpers
- M Meichsner
- M Perez
- M Ray
- M Rehbein
- M Sirajuddin
- M Stiess
- M Venoux
- M Vershinin
- MA Davare
- MA Tischfield
- MA Tischfield
- MA Tischfield
- MC Choi
- MC DiTella
- MC Manzini
- MC Stone
- MD Weingarten
- MF Carlier
- MH Bre
- ML Frandemiche
- ML Reese
- MM Black
- MM Black
- MM Mocanu
- MM Rolls
- MO Collins
- MR Galiano
- N Fabre-Jonca
- N Hirokawa
- N Hirokawa
- N Iriuchijima
- N Kalcheva
- N Kobayashi
- N Murakami
- N Ohkawa
- N Sharma
- N Yamashita
- N Yamashita
- NA Reed
- NS Jalava
- OI Kahn
- P Brun
- P Fanara
- P Holmfeldt
- P Holmfeldt
- P Lei
- P Merino-Serrais
- P Opal
- P Velazquez-Bernardino
- PF Good
- PH Jensen
- PH Jensen
- PJ Lu
- PM Canas
- PR Burton
- PR Gordon-Weeks
- PS Yamauchi
- PW Baas
- PW Baas
- PW Baas
- PW Baas
- QL Ma
- R Bernhardt
- R Bernhardt
- R Brandt
- R Calvert
- R Dhamodharan
- R Dixit
- R Hartel
- R Lu
- R Takemura
- R Xie
- RA Obar
- RB Maccioni
- RB Vallee
- RB Vallee
- RB Vallee
- RD Burgoyne
- RD Vale
- RH Takahashi
- RJ Code
- RJ Kowalski
- RL Fradley
- RP Tucker
- RP Tucker
- RP Tucker
- RP Tucker
- RR West
- RT Terry-Lorenzo
- RW Lim
- S Brot
- S Dunn
- S Halpain
- S Heins
- S Ikegami
- S Illenberger
- S Jinushi-Nakao
- S Karki
- S Kawakami
- S Kotani
- S Lin
- S Okabe
- S Salinas
- S Wolff
- SA Przyborski
- SC Hwang
- SC Papasozomenos
- SC Papasozomenos
- SC Selden
- SE Siegrist
- SG Mansfield
- SJ Chapin
- SL Chan
- SL Gonzalez
- SM Park
- SP Zamora-Leon
- SR Tymanskyj
- SS Chin
- SV Bratman
- T Bittner
- T Doll
- T Kawauchi
- T Kleele
- T Metzger
- T Mitchison
- T Scholz
- T Shirao
- T Slaughter
- T Stepanova
- TA Maniar
- TA Schoenfeld
- TA Schoenfeld
- TJ Itoh
- TM Scales
- U Beffert
- V Brown
- V Fournet
- V Fournet
- V Fournet
- W Edelmann
- W Wang
- W Yu
- WB Grueber
- WE Theurkauf
- WJ Chung
- WJ Strittmatter
- WN Hait
- X Hu
- XH Jaglin
- XH Jaglin
- XP Ryan
- XX Yan
- Y Chen
- Y Fukata
- Y Kanai
- Y Kanai
- Y Kanai
- Y Konishi
- Y Song
- Y Takei
- Y Takei
- Y Takei
- Y Zheng
- Z Khuchua
- Z Orban-Nemeth
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Dendrites have a unique microtubule organization. In vertebrates, dendritic microtubules are organized in antiparallel bundles, oriented with their plus ends either pointing away or toward the soma. The mixed microtubule arrays control intracellular trafficking and local signaling pathways, and are essential for dendrite development and function. The organization of microtubule arrays largely depends on the combined function of different microtubule regulatory factors or generally named microtubule-associated proteins (MAPs). Classical MAPs, also called structural MAPs, were identified more than 20 years ago based on their ability to bind to and copurify with microtubules. Most classical MAPs bind along the microtubule lattice and regulate microtubule polymerization, bundling, and stabilization. Recent evidences suggest that classical MAPs also guide motor protein transport, interact with the actin cytoskeleton, and act in various neuronal signaling networks. Here, we give an overview of microtubule organization in dendrites and the role of classical MAPs in dendrite development, dendritic spine formation, and synaptic plasticity
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- Author
- Aaij R
- Abdelmotteleb ASW
- Abellan Beteta C
- Abudinén F
- Achard C
- Ackernley T
- Adeva B
- Adinolfi M
- Adlarson P
- Afsharnia H
- Agapopoulou C
- Aidala CA
- Ajaltouni Z
- Akar S
- Akiba K
- Albicocco P
- Albrecht J
- Alessio F
- Alexander M
- Alfonso Albero A
- Aliouche Z
- Alvarez Cartelle P
- Amalric R
- Amato S
- Amey JL
- Amhis Y
- An L
- Anderlini L
- Andersson M
- Andreani A
- Andreianov A
- Andreotti M
- Andreou D
- Andrews JE
- Anelli M
- Anjam A
- Ao D
- Archilli F
- Arnaud K
- Artamonov A
- Artuso M
- Ashby J
- Aslanides E
- Atzeni M
- Audurier B
- Ayres Rocha D
- Bachiller Perea IB
- Bachmann S
- Bachmayer M
- Back JJ
- Bailly-reyre A
- Baladron Rodriguez P
- Balagura V
- Balbi G
- Baldini W
- Balla A
- Baltazar M
- Band H
- Baptista de Souza Leite J
- Barbetti M
- Barclay P
- Barlow RJ
- Barsuk S
- Barter W
- Bartolini M
- Baryshnikov F
- Basels JM
- Bassi G
- Baszczyk M
- Batista Lopes JC
- Batsukh B
- Battig A
- Bay A
- Beck A
- Becker M
- Bedeschi F
- Bediaga IB
- Beigbeder-Beau C
- Beiter A
- Belin S
- Bellee V
- Belous K
- Belov I
- Belyaev I
- Ben-Haim E
- Benane G
- Bencivenni G
- Benettoni M
- Berezhnoy A
- Bernard F
- Bernet Andres S
- Bernet R
- Berninghoff D
- Bernstein HC
- Bertella C
- Bertolin A
- Betancourt C
- Betti F
- Bezshyiko Ia
- Bezshyyko O
- Bhasin S
- Bhom J
- Bian L
- Bieker MS
- Biesuz NV
- Billoir P
- Biolchini A
- Birch M
- Bishop FCR
- Bitadze A
- Bizzeti A
- Blago MP
- Blake T
- Blanc F
- Blank JE
- Blusk S
- Bobulska D
- Bochin B
- Boelhauve JA
- Boente Garcia O
- Boettcher T
- Bogdanova G
- Boiaryntseva I
- Boldyrev A
- Bolognani CS
- Bolzonella R
- Bondar N
- Booth MJ
- Borgato F
- Borghi S
- Borsato M
- Borsuk JT
- Boterenbrood H
- Bouchiba SA
- Bowcock TJV
- Boyaryntsev A
- Boyer A
- Bozzi C
- Bradley MJ
- Braun S
- Brea Rodriguez A
- Bregliozzi G
- Bridges K
- Briere MMJ
- Brock M
- Brodski M
- Brodzicka J
- Brossa Gonzalo A
- Brown C
- Brown J
- Brummitt AJ
- Brundu D
- Brunetti L
- Buda L
- Buonaura A
- Buonincontri L
- Burke AT
- Burmistrov L
- Burr C
- Bursche A
- Butkevich A
- Butter JS
- Buytaert J
- Byczynski W
- Cachemiche JP
- Cadeddu S
- Cai H
- Caillet A
- Calabrese R
- Calefice L
- Calegari D
- Cali S
- Calvi M
- Calvo Gomez M
- Campana P
- Campora Perez DH
- Campoverde Quezada AF
- Canfer S
- Capelli S
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- Zuliani D
- Zunica G
- Zvyagintsev S
- Publication venue
- Journal of Instrumentation
- Publication date
- 23/05/2024
- Field of study
Abstract
The LHCb upgrade represents a major change of the
experiment. The detectors have been almost completely renewed to
allow running at an instantaneous luminosity five times larger than
that of the previous running periods. Readout of all detectors into
an all-software trigger is central to the new design, facilitating
the reconstruction of events at the maximum LHC interaction rate,
and their selection in real time. The experiment's tracking system
has been completely upgraded with a new pixel vertex detector, a
silicon tracker upstream of the dipole magnet and three
scintillating fibre tracking stations downstream of the magnet. The
whole photon detection system of the RICH detectors has been renewed
and the readout electronics of the calorimeter and muon systems have
been fully overhauled. The first stage of the all-software trigger
is implemented on a GPU farm. The output of the trigger provides a
combination of totally reconstructed physics objects, such as tracks
and vertices, ready for final analysis, and of entire events which
need further offline reprocessing. This scheme required a complete
revision of the computing model and rewriting of the experiment's
software.</jats:p