5 research outputs found
The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
- Author
- A Coxon
- A Hamadi
- A He
- A Kouskouti
- AA Price
- AD Tran
- AJ GarcĂa
- Alexandre R Gingras
- AR Gingras
- B Czermin
- B Polevoda
- C Coisne
- C Huang
- CL Abram
- CN Pang
- D GarcĂa-Bernal
- DH Yu
- DR Critchley
- E Ezhkova
- E Goksoy
- F Zhang
- Florent Ginhoux
- G Giannone
- GG Pendl
- H Kontaki
- Heidi Berger
- I-hsin Su
- IH Su
- IH Su
- J Huang
- J van der Vlag
- Jia Tong Loh
- JM Lee
- Jong Fu Wong
- K Ley
- Keh Chuang Chin
- KS Egorova
- L Kruidenier
- Lai Guan Ng
- Liang Yao Jackson Li
- M Sixt
- Merry Gunawan
- MT Bedford
- Myint Khun La Win
- N Hogg
- Nandini Venkatesan
- O Hobert
- P Friedl
- P Jain
- Peter Chi Ee See
- R Alon
- R Margueron
- R Mukasa
- S Chuikov
- S Erhardt
- Sayuri Yamazaki
- SC Howes
- Siu Kwan Sze
- SJ Franco
- Susana Geifman Shochat
- T LĂ€mmermann
- TA Springer
- TD Ross
- Tiannan Guo
- Wen Hao Neo
- XD Ren
- XD Yang
- Yin Hoe Yau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation has been suggested, but the molecular mechanisms underpinning this extranuclear function have remained unclear. Here we found that Ezh2 regulated the integrin signaling and adhesion dynamics of neutrophils and dendritic cells (DCs). Ezh2 deficiency impaired the integrin-dependent transendothelial migration of innate leukocytes and restricted disease progression in an animal model of multiple sclerosis. Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures. This regulatory effect was abolished by targeted disruption of the interactions of Ezh2 with the cytoskeletal-reorganization effector Vav1. Our studies reveal an unforeseen extranuclear function for Ezh2 in regulating adhesion dynamics, with implications for leukocyte migration, immune responses and potentially pathogenic processes.NMRC (Natl Medical Research Council, Sâpore)MOE (Min. of Education, Sâpore)ASTAR (Agency for Sci., Tech. and Research, Sâpore)Accepted versio
The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
- Author
- A Coxon
- A Hamadi
- A He
- A Kouskouti
- AA Price
- AD Tran
- AJ GarcĂa
- Alexandre R Gingras
- AR Gingras
- B Czermin
- B Polevoda
- C Coisne
- C Huang
- CL Abram
- CN Pang
- D GarcĂa-Bernal
- DH Yu
- DR Critchley
- E Ezhkova
- E Goksoy
- F Zhang
- Florent Ginhoux
- G Giannone
- GG Pendl
- H Kontaki
- Heidi Berger
- I-hsin Su
- IH Su
- IH Su
- J Huang
- J van der Vlag
- Jia Tong Loh
- JM Lee
- Jong Fu Wong
- K Ley
- Keh Chuang Chin
- KS Egorova
- L Kruidenier
- Lai Guan Ng
- Liang Yao Jackson Li
- M Sixt
- Merry Gunawan
- MT Bedford
- Myint Khun La Win
- N Hogg
- Nandini Venkatesan
- O Hobert
- P Friedl
- P Jain
- Peter Chi Ee See
- R Alon
- R Margueron
- R Mukasa
- S Chuikov
- S Erhardt
- Sayuri Yamazaki
- SC Howes
- Siu Kwan Sze
- SJ Franco
- Susana Geifman Shochat
- T LĂ€mmermann
- TA Springer
- TD Ross
- Tiannan Guo
- Wen Hao Neo
- XD Ren
- XD Yang
- Yin Hoe Yau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular mechanisms of dendritic cell migration in immunity and cancer
- Author
- A Bergsma
- A Braun
- A Engering
- A Kissenpfennig
- A Link
- A Nishibu
- A Smith
- A van Rijn
- AB van Spriel
- AC Villani
- AD McLellan
- AL Fletcher
- AR Shaw
- B Vigl
- BA Mannion
- BU Schraml
- C Aerts-Toegaert
- C Auffray
- C Conrad
- C LagaudriĂšre-Gesbert
- C Reis e Sousa
- CA Janeway
- CG Figdor
- CL Willard-Mack
- CM de Winde
- CM de Winde
- CM Termini
- CP Larsen
- CR Perez
- CS Garris
- D Alvarez
- D Hanahan
- D Hanahan
- D Kerjaschki
- D MourĂŁo-SĂĄ
- D Wang
- DY Ma
- E Ingulli
- E Rubinstein
- E Russo
- E Tejera
- EL Doyle
- EL Jones
- EP Kaldjian
- EW Roberts
- F Geissmann
- F Ginhoux
- F Granucci
- F Ikomi
- F Sallusto
- F Sallusto
- F Schaper
- F Weber
- FR Balkwill
- G Charras
- G Faure-André
- G Reynolds
- GG Pendl
- GM Halliday
- H Pflicke
- H Saito
- H Takamatsu
- H Zhang
- HD Moreau
- HT Maecker
- HV Prentice-Mott
- I Todros-Dawda
- J Banchereau
- J Deckers
- J Faget
- J Franz
- J Renkawitz
- J Szöllósi
- J Tel
- J Valenzuela
- JD Pancook
- JJP van Beek
- JL Wee
- JM Trevejo
- JP Böttcher
- JP Böttcher
- K Imai
- K Liu
- K Rottner
- K Suzuki-Inoue
- K Vaahtomeri
- K-CC Sheng
- KG Elpek
- KH Gartlan
- KL Rock
- KP Knobeloch
- L Cao
- L Maddaluno
- L Peduto
- L Yeung
- LA Johnson
- LA Johnson
- LA Johnson
- LM Kranz
- M AlcĂĄntara-HernĂĄndez
- M Bergert
- M Chabaud
- M Collin
- M Ito
- M Nitschké
- M Ogata
- M Swiecki
- M Weber
- M Wieczorek
- M Zuidscherwoude
- M Zuidscherwoude
- MA Hauser
- MA Nolte
- ME Mummert
- ML Arbonés
- ML Saiz
- MR Britschgi
- MS Hayden
- N Shibagaki
- NQ Balaban
- O Krysko
- O Schulz
- O Tal
- P Angelisova
- P Baluk
- P Björck
- P Bousso
- P Matzinger
- P Vargas
- PF Maness
- PG Coulie
- PJ SĂĄez
- PL Sorgen
- PPH de Bruyn
- R Förster
- R Reyes
- R Ruez
- RC Fields
- RJ Petrie
- RM Steinman
- RN Germain
- S Akira
- S Balkow
- S Banerji
- S Charrin
- S Gallucci
- S Hangai
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- SE Acton
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- U Haessler
- U OâDoherty
- UE Höpken
- V Flamand
- V Karamatic Crew
- VE Dunlock
- WR Legant
- X Jiang
- Y Hasegawa
- Y Nakazawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Störungen des Kaliumstoffwechsels und ihre klinische Bedeutung
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- A Ballabriga
- A Berardi
- A Bernhard
- A Biemond
- A Buck
- A Coletta
- A Dury
- A Dury
- A Dury
- A Dury
- A Falbriard
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Fleckenstein
- A Friedman
- A Gilman
- A Grundner-Culemann
- A Hilgers
- A Iannaccone
- A Jarisch
- A Kornberg
- A Krogh
- A Krogh
- A Leap
- A Leap
- A Lichtwitz
- A Löwenthal
- A Manitius
- A Oer v
- A Portella
- A Prader
- A Prader
- A Prader
- A Prader
- A Prader
- A Prader
- A Reinbebg
- A Reinbebg
- A Reinbebg
- A Reinbebg
- A Rosenkbanz
- A Rothstein
- A Ruiz-GuinazĂș
- A Segunti
- A Stechern
- A Svendsen
- A Szent-Györgyi
- A Voelkel
- A Warming-Larsen
- A Wollenberger
- A Wollenberger
- AA Falbriard
- AC Ernstene
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- AG Bower
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- AH Hegnauer
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- AJ Aballi
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- AW Winkler
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- B Lown
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- Electrolyte changes and the electrocardiogram in diabetic acidosis
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- P Uhry
- P Vallery-Radot
- P Vallery-Radot
- P Weichsel
- PA Bott
- PA SantâAgnese Di
- PB Pearson
- PD Boyer
- PD Boyer
- PD Saville
- PE Jackson
- PE Tuynman
- PG Frost
- PG Kiss
- PH Clodi
- PH Dost
- PH Jeanneret
- PH Jeanneret
- PH Leiderman
- PH Rossier
- PJ Boyle
- PJ Talso
- PJ Talso
- PJ Talso
- PK Boyer
- PM Hald
- PM Magee
- PM McAllen
- PM Traverse de
- PN Witt
- PR Cannon
- PR Cannon
- PS Hagen
- PS Larson
- PT Hald
- R Albrecht
- R Charlier
- R Debré
- R Debré
- R Debré
- R Elman
- R Elman
- R Fischer
- R François
- R Gaunt
- R Gazmuri
- R Gostof
- R GrĂŒttner
- R Hazard
- R Hazard
- R Hazard
- R Hazard
- R Hazard
- R Hegglin
- R Hegglin
- R Herrmann
- R Hoigné
- R Holmes
- R Höber
- R Jean
- R Kilpatrick
- R Kilpatrick
- R Kunin
- R Kunin
- R Lightwood
- R Lohmann-Peschel
- R Luft
- R McLean
- R Mond
- R Montant
- R MĂŒnchinger
- R Pitts
- R Prosiegel
- R Prosiegel
- R Sacrez
- R Sacrez
- R Scapaticci
- R Scapaticci
- R Schorer
- R Schwartz
- R Schwartz
- R Schwartz
- R Tarail
- R Taugner
- R Teabeaut
- R Tobler
- R Valencia
- R Womersley
- RA Huggins
- RA Kelley
- RA McNaughton
- RA Neubacher
- RA Scibert
- RB Goldbloom
- RB Robebts
- RB Tobin
- RC Eley
- RC Swann
- RD Eastham
- RD Squires
- RE Bernstein
- RE Bernstein
- RE Berry
- RE Cooke
- RE Cooke
- RE Cooke
- RE Cooke
- RE Davies
- RE Hazard
- RE Mosher
- RF Mahler
- RG Smith
- RG Sprague
- RH Follis
- RH Huggins
- RH Pudenz
- RH Rosenman
- RH Rosenman
- RH Rosenman
- RH Rosenman
- RH Rosenman
- RH Sinden
- RH Swigart
- RJ Hall
- RL Zwemer
- RM Myerson
- RM Todd
- RO Muether
- RP Bolande
- RP Escamillo
- RP Long de
- RP Pitts
- RR Overman
- RR Overman
- RS Aitken
- RS Mach
- RS Palmer
- RS Yalow
- RT Smith
- RV Murphy
- RW Berliner
- RW Berliner
- RW Berliner
- RW Berliner
- RW Berliner
- RW Berliner
- RW Korff
- RWT Berliner
- S Bellet
- S Bellet
- S Bellet
- S Daum
- S Dreizen
- S Garb
- S George
- S Hajdu
- S Raboport
- S Raboport
- S Ringeb
- SA Simpson
- SA Simpson
- SA Threefoot
- SandkĂŒhler
- SB TĂŒmay
- SC Freed
- SC Freed
- SC Freed
- SC Freed
- SC Freed
- SC Freed
- SC Freed
- SD Snyder
- SE Kerr
- SE Simon
- SG Smith
- SH Alatas
- SI Zacks
- SJ Björklund
- SJ Björklund
- SJ Faber
- SJ Faber
- SJ Faber
- SK Wilhelm
- SM Perry
- SM Walker
- SP Gottfried
- SW Stanbury
- SW Stanbury
- SW Stanbury
- T Adler
- T Ando
- T Brehme
- T Danowski
- T Iversen
- T Lewenfisz-Wojnarowska
- T Sjöstrand
- T Stapleton
- T Stapleton
- T Stengebs
- TB Reynolds
- TJ Kennedy Jr.
- TJ Regan
- TN Pulman
- TP Frawley
- TP Frawley
- TR Harrison
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TS Danowski
- TT Amatruda
- U Sagild
- V Moseley
- V Vermooten
- VC Myers
- VE Hall
- VH Cicardo
- VH Cicardo
- VH Cicardo
- W Bolt
- W Brednow
- W Brenner
- W Brenner
- W Cayley de
- W Droese
- W Droese
- W Emdin
- W Hadorn
- W Kobingeb
- W Mandel
- W Myers
- W Rupp
- W Stark
- W Telo
- W Telo
- W Telo
- W Telo
- W Telo
- W Thieme
- WA Campbell
- WB Macdonald
- WB Schwartz
- WB Weil
- WC Boyce
- WC Holland
- WC Schneider
- WCL Diefenbach
- WD Blake
- WD Love
- WD Love
- WD Schwartz
- WD Schwartz
- WD Schwartz
- WG Liddle
- WG Smillie
- WG Walker
- WH Blahd
- WHH Tegelaers
- WHH Tegelaers
- WJ Eisenmenger
- WJ Eversole
- WJ Kolff
- WJ Pirozynski
- WL Arons
- WL Arons
- WL Perry
- WL Weinland
- WM Kelsey
- WM Nicholson
- WM Nicholson
- WO Fenn
- WO Fenn
- WO Fenn
- WO Fenn
- WO Frnn
- WS Beck
- WS Hoffmann
- WS Hoffmann
- WS Wilde
- WVB Robebtson
- WVB Robebtson
- WW Payne
- WW Swingle
- Y Labsson
- Y Tsukada
- ZM Bacq
- ZM Bacq
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1958
- Field of study
Bareroot versus container stocktypes: a performance comparison
- Author
- A Lindström
- A Mattsson
- A Mena-Petite
- A Mena-Petite
- A Sakai
- A Vyse
- A Youngblood
- AA Alm
- AA Alm
- AC Balisky
- AJ Thomson
- AJ Thomson
- AL Sharpe
- AM Quoreshi
- AN Burdett
- AN Burdett
- AN Burdett
- AN Burdett
- AN Burdett
- B Cuesta
- B Cuesta
- B Lui
- B Payandeh
- BD Cleary
- BP Dickerson
- BP Dickerson
- C OâReilly
- CA Becker
- CA Doggett
- CA Harrington
- CGR Chavasse
- CL Preisig
- D Hocking
- D Pilz
- D Struve
- DA RodrĂguez-Trejo
- DB South
- DB South
- DB South
- DB South
- DB South
- DB South
- DB South
- DB South
- DB South
- DB South
- DC Dey
- DD Crunkilton
- DD McCreary
- DG Simpson
- DG Simpson
- DH Gjerstad
- DH Marx
- DL Wenny
- DM Morris
- DP Jackson
- DP White
- DV Shaw
- E Chirino
- E Eerden van
- E Mason
- E Sundström
- E Wilson
- EC Cole
- EC Stone
- EI Stjernberg
- F Renou
- F Renou-Wilson
- FT Pendl
- FW Althen von
- FW Althen von
- FW Woods
- G Kerr
- G Rune
- GA Ritchie
- GA Ritchie
- GA Walters
- GB MacDonald
- GE Mackinnon
- GF Gruschow
- GG Wang
- GH Kokocinski
- GH Mohammed
- GH Mohammed
- GW Wendel
- H Jaenicke
- H Poorter
- HA Margolis
- HM McKay
- HM McKay
- HM McKay
- HM Williams
- HW Barber Jr
- I Yuyitung
- J Hytönen
- J Leugner
- J Levitt
- J Paterson
- JA Kusler
- JC Brissette
- JC Brissette
- JC Brissette
- JC Haywood
- JD Deans
- JD Johnson
- JE Wood
- JE Wood
- JE Wood
- JF Dickson
- JG Mexal
- JJ Zaczek
- JJ Zaczek
- JL Ruehle
- JL Ruehle
- JL Yeiser
- JM Balneaves
- JM Kinghorn
- JP Barnett
- JP Barnett
- JP Barnett
- JP Barnett
- JR Pinto
- JR Seiler
- JS Meadows
- JT Arnott
- JT Arnott
- JT Arnott
- JT Arnott
- JW Toumey
- K Odlum
- KH Johnsen
- KM Howard
- LE Riley
- LH Fuchigami
- LH Fuchigami
- LS Rosner
- LW Carlson
- M Idris
- M Newton
- M Newton
- MA Sword Sayer
- MD Abrams
- MJ Jaffe
- ML Duryea
- ML Duryea
- MM Cram
- MP Coutts
- MR Halter
- MR Halter
- N Thiffault
- N Thiffault
- N Thiffault
- N Thiffault
- N Thiffault
- N Thiffault
- O Langvall
- OA Okafo
- OC Goodwin
- OT Helgerson
- OT Helgerson
- OT Helgerson
- OT Helgerson
- P Villar-Salvador
- PC Wakeley
- PC Wakeley
- PF Hahn
- PF Hahn
- PJ Kramer
- PM McDonald
- PM Tabbush
- PM Tabbush
- PO Woolery
- PO Woolery
- PP Feret
- PP Kormanik
- PS Johnson
- PS Johnson
- PS Johnson
- PS Johnson
- PV West van
- PW Owston
- R Driessche van den
- R Driessche van den
- R Driessche van den
- R Hunt
- R Jinks
- R Jobidon
- R Jobidon
- R Rose
- R Rose
- R Sands
- R Timmis
- RA Fleming
- RA Klawitter
- RA Kluender
- RA Lautenschlager
- RC Morrissey
- RD Iverson
- RF Sutton
- RH Waring
- RJ Echols
- RK Dixon
- RK Dixon
- RK Dumroese
- RL Hay
- RL Hay
- RL Jinks
- RM Girouard
- RM Teclaw
- RO Teskey
- RW Guldin
- SC Grossnickle
- SC Grossnickle
- SC Grossnickle
- SC Grossnickle
- SC Grossnickle
- SC Grossnickle
- SC Grossnickle
- SC Hunter
- SD Hobbs
- SD Hobbs
- SG Whisenant
- SJ Colombo
- SJ Rowe
- SN Jutras
- SP Marion
- SR Radosevich
- SS Sung
- Steven C. Grossnickle
- TD Daniels
- TE Starkey
- TJ Blake
- TJ Nichols
- TT Kozlowski
- TT Kozlowski
- TT Kozlowski
- U Nilsson
- U Nilsson
- VC Baldwin
- VR Timmer
- WC Carlson
- WC Carlson
- WC Parker
- WD Binder
- WD Boyer
- WD Walter
- WE Waters
- WF Mann
- WH Conner
- WH Davidson
- WI Stein
- WI Stein
- WK Mitchell
- WL Mason
- WR Nelson
- WT Gladstone
- Y Wang
- Yousry A. El-Kassaby
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study