10,772 research outputs found
Degree spectra for transcendence in fields
We show that for both the unary relation of transcendence and the finitary
relation of algebraic independence on a field, the degree spectra of these
relations may consist of any single computably enumerable Turing degree, or of
those c.e. degrees above an arbitrary fixed degree. In other
cases, these spectra may be characterized by the ability to enumerate an
arbitrary set. This is the first proof that a computable field can
fail to have a computable copy with a computable transcendence basis
Elastic effects on relaxation volume tensor calculations
Relaxation volume tensors quantify the effect of stress on diffusion of
crystal defects. Continuum linear elasticity predicts that calculations of
these parameters using periodic boundary conditions do not suffer from
systematic deviations due to elastic image effects and should be independent of
supercell size or symmetry. In practice, however, calculations of formation
volume tensors of the interstitial in Stillinger-Weber silicon
demonstrate that changes in bonding at the defect affect the elastic moduli and
result in system-size dependent relaxation volumes. These vary with the inverse
of the system size. Knowing the rate of convergence permits accurate estimates
of these quantities from modestly sized calculations. Furthermore, within the
continuum linear elasticity assumptions the average stress can be used to
estimate the relaxation volume tensor from constant volume calculations.Comment: 31 pages, 6 figures, submitted to Phys. Rev.
Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity
A series of bismuth–dicarboxylate–deferiprone coordination networks have been prepared and structurally characterised. The new compounds have been demonstrated to release the iron overload drug deferiprone on treatment with PBS and have also been shown to have antibacterial activity against H. pylori
THE COMBINATION PROBLEM FOR PANPSYCHISM: A CONSTITUTIVE RUSSELLIAN SOLUTION An Investigation into Phenomenal Bonding Panpsychism and Composite Subjects of Experience
In this thesis I argue for the following theory: constitutive Russellian phenomenal bonding panpsychism. To do so I do three main things: 1) I argue for Russellian panpsychism. 2) I argue for phenomenal bonding panpsychism. 3) I defend the resultant phenomenal bonding panpsychist model. The importance of arguing for (and defending) such a theory is that if it can be made to be viable, then it is proposed to be the most promising theory of the place of consciousness within nature (Chalmers, 2016a; Strawson, 2006a). This is because constitutive Russellian panpsychism has all the theoretical virtues of physicalism and dualism but does not face the problems they do (Alter and Nagasawa, 2015a; Chalmers, 2016a). The combination problem, however, is the most significant problem for the Russellian panpsychist (Chalmers, 2016b; Goff, 2017a), and, hence, in order to show the viability of the theory I address this problem. Moreover, I present a novel ‘mereological argument’ for panpsychism which makes it necessary that the Russellian panpsychist addresses (and solves) the combination problem. The focus of this thesis is therefore addressing this problem. I argue that the combination problem can indeed be solved. To do so I argue for the phenomenal bonding solution proposed by Goff (Goff, 2016, 2009a). I argue that this solution works and that we can form a positive concept of the phenomenal bonding relation (Miller, 2017). This forces the panpsychist to make sense of how experiencing subjects can be proper parts of other experiencing subjects (Miller, 2018). I then argue that this can indeed be made sense of and show that we can indeed be composite subjects made of other subjects. To show that we can be subjects made up of other subjects I defend this proposal from various objections from throughout the literature. All these objections can be responded to by the constitutive Russellian phenomenal bonding panpsychist. Ultimately this leaves us with a novel and interesting account of what conscious subjects are, and what the material world is: they are both composite entities made wholly of conscious matter
Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells
This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restricted to the lung and pathological changes were clearly evident at 1.5 and 4 h post-injection but were largely resolved by 24 h. Histology of DBP+/+ lungs revealed noticeably more vascular leakage, hemorrhage and thickening of the alveolar wall. Flow cytometry analysis of whole lung homogenates showed significantly increased neutrophil infiltration into DBP+/+ mouse lungs at 1.5 and 4h. Increased amounts of protein and leukocytes were also noted in bronchoalveolar lavage fluid from DBP+/+. mice 4 h after actin injection. In vitro, purified DBP-actin complexes did not activate complement or neutrophils but induced injury and death of cultured human lung microvascular endothelial cells (HLMVEC) and human umbilical vein endothelial cells (HUVEC). Cells treated with DBP-actin showed a significant reduction in viability at 4 h, this effect was reversible if cells were cultured in fresh media for another 24 h. However, a 24-h treatment with DBP-actin complexes showed a significant increase in cell death (95% for HLMVEC, 45% for HUVEC). The mechanism of endothelial cell death was via both caspase-3 dependent (HUVEC) and independent (HLMVEC) pathways. These results demonstrate that elevated levels and/or prolonged exposure to DBP-actin complexes may induce endothelial cell injury and death, particularly in the lung microvasculature. (C) 2013 Elsevier GmbH. All rights reserved
Recent Progress in Neutron Star Theory
This review contains chapters discussing: Energy density fluctionals of
nuclear matter, Many-body theory of nucleon matter, Hadronic and quark matter,
Mixtures of phases in dense matter, Neutron star observations and predictions.Comment: 33 pages +13 figs., Ann. Rev. Nucl. & Part. Science, 200
Polynomial Interrupt Timed Automata
Interrupt Timed Automata (ITA) form a subclass of stopwatch automata where
reachability and some variants of timed model checking are decidable even in
presence of parameters. They are well suited to model and analyze real-time
operating systems. Here we extend ITA with polynomial guards and updates,
leading to the class of polynomial ITA (PolITA). We prove the decidability of
the reachability and model checking of a timed version of CTL by an adaptation
of the cylindrical decomposition method for the first-order theory of reals.
Compared to previous approaches, our procedure handles parameters and clocks in
a unified way. Moreover, we show that PolITA are incomparable with stopwatch
automata. Finally additional features are introduced while preserving
decidability
Undergraduate medical textbooks do not provide adequate information on intravenous fluid therapy: a systematic survey and suggestions for improvement
<b>Background</b><p></p>
Inappropriate prescribing of intravenous (IV) fluid, particularly 0.9% sodium chloride, causes post-operative complications. Fluid prescription is often left to junior medical staff and is frequently poorly managed. One reason for poor intravenous fluid prescribing practices could be inadequate coverage of this topic in the textbooks that are used.<p></p>
<b>Methods</b><p></p>
We formulated a comprehensive set of topics, related to important common clinical situations involving IV fluid therapy, (routine fluid replacement, fluid loss, fluids overload) to assess the adequacy of textbooks in common use. We assessed 29 medical textbooks widely available to students in the UK, scoring the presence of information provided by each book on each of the topics. The scores indicated how fully the topics were considered: not at all, partly, and adequately. No attempt was made to judge the quality of the information, because there is no consensus on these topics.<p></p>
<b>Results</b><p></p>
The maximum score that a book could achieve was 52. Three of the topics we chose were not considered by any of the books. Discounting these topics as “too esoteric”, the maximum possible score became 46. One textbook gained a score of 45, but the general score was poor (median 11, quartiles 4, 21). In particular, coverage of routine postoperative management was inadequate.<p></p>
<b>Conclusions</b><p></p>
Textbooks for undergraduates cover the topic of intravenous therapy badly, which may partly explain the poor knowledge and performance of junior doctors in this important field. Systematic revision of current textbooks might improve knowledge and practice by junior doctors. Careful definition of the remit and content of textbooks should be applied more widely to ensure quality and “fitness for purpose”, and avoid omission of vital knowledge
5-{2-[(2-Hydroxy-5-methylphenyl)(phenyl)methyleneamino]phenyliminomethyl}pyrrole-2-carbaldehyde
The title compound, C26H21N3O2, is an unsymmetrical tetradentate Schiff base ligand. The hydroxy group forms an intramolecular O—H⋯N hydrogen bond with an adjacent N atom. An intermolecular N—H⋯O hydrogen bond creates centrosymmetric dimers in the crystal packing
Relativistic Mean-Field Theory Equation of State of Neutron Star Matter and a Maxwellian Phase Transition to Strange Quark Matter
The equation of state of neutron star matter is examined in terms of the
relativistic mean-field theory, including a scalar-isovector -meson
effective field. The constants of the theory are determined numerically so that
the empirically known characteristics of symmetric nuclear matter are
reproduced at the saturation density. The thermodynamic characteristics of both
asymmetric nucleonic matter and -equilibrium hadron-electron
-plasmas are studied. Assuming that the transition to strange quark matter
is an ordinary first-order phase transition described by Maxwell's rule, a
detailed study is made of the variations in the parameters of the phase
transition owing to the presence of a -meson field. The quark phase is
described using an improved version of the bag model, in which interactions
between quarks are accounted for in a one-gluon exchange approximation. The
characteristics of the phase transition are determined for various values of
the bag parameter within the range and it is shown
that including a -meson field leads to a reduction in the phase
transition pressure and in the concentrations and at
the phase transition point.Comment: 17 pages, 8 figure
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