ISOTOPIC ANALYSIS OF JURASSIC (CALLOVIAN) MOLLUSKS FROM THE CHRISTIAN MALFORD LAGERSTATTE (UK): IMPLICATIONS FOR OCEAN WATER TEMPERATURE ESTIMATES BASED ON BELEMNOIDS

Isotopic data (C and O) derived from Callovian (Middle Jurassic) mollusks (bivalves, ammonites and belemnoids, including true belemnites and Belemnotheutis) are presented from a narrow stratigraphic interval in the Christian Malford Lagerstätte, UK. The exceptionally well-preserved mollusks include aragonite-calcite pairs precipitated by individual belemnite animals that enable an assessment of possible “vital” effects and the reliability of using belemnite calcite to determine ocean water compositions. The oxygen isotope data derived from the calcitic rostra of the belemnites (Cylindroteuthis) show modest variability, ranging from −1.2 to 0.9‰ (V-PDB), while their accompanying aragonitic phragmocones range from −1.4 to 0.0‰. Data derived from the ammonite Kosmoceras show some scatter, with oxygen isotope values varying from −3.6 to −0.2‰. The aragonite data from Cylindroteuthis, Kosmoceras and Belemnotheutis all overlap, suggesting they inhabited similar (surface) water depths. However, the corresponding data from the calcitic rostra of the Cylindroteuthis specimens suggest temperatures ∼ 5°C cooler. As we have analyzed aragonite-calcite pairs, the discrepancy cannot be explained by environmental effects. Though clearly a vital effect, it is difficult to resolve whether the temperatures derived from the aragonite (phragmocone) are too warm or from the calcite (rostrum) are too cool. Consequently, the applicability of standard paleotemperature equations to Cylindroteuthid belemnite rostra remains unproven. Sequentially sampled ontogenetic isotope data derived from Belemnotheutis phragmocones reveal only modest δ18O variation, consistent with limited movement between warmer (shallower) and cooler (deeper) waters. A coincidental systematic pattern of δ13C enrichment may signal changes in metabolic activity associated with a shift in ecology or feeding with age

The history of the Y chromosome in man

Studies of the Y chromosome over the past few decades have opened a window into the history of our species, through the reconstruction and exploitation of a patrilineal (Y-genealogical) tree based on several hundred single-nucleotide variants (SNVs). A new study validates, refines and extends this tree by incorporating >65,000 Y-linked variants identified in 1,244 men representing worldwide diversity

Characterization of hunter-gatherer networks and implications for cumulative culture

Social networks in modern societies are highly structured, usually involving frequent contact with a small number of unrelated friends' 1. However, contact network structures in traditional small-scale societies, especially hunter-gatherers, are poorly characterized. We developed a portable wireless sensing technology (motes) to study within-camp proximity networks among Agta and BaYaka hunter-gatherers in fine detail. We show that hunter-gatherer social networks exhibit signs of increased efficiency 2 for potential information exchange. Increased network efficiency is achieved through investment in a few strong links among non-kin friends' connecting unrelated families. We show that interactions with non-kin appear in childhood, creating opportunities for collaboration and cultural exchange beyond family at early ages. We also show that strong friendships are more important than family ties in predicting levels of shared knowledge among individuals. We hypothesize that efficient transmission of cumulative culture 3-6 may have shaped human social networks and contributed to our tendency to extend networks beyond kin and form strong non-kin ties

Aidnogenesis via Leptogenesis and Dark Sphalerons

We discuss aidnogenesis, the generation of a dark matter asymmetry via new sphaleron processes associated to an extra non-abelian gauge symmetry common to both the visible and the dark sectors. Such a theory can naturally produce an abundance of asymmetric dark matter which is of the same size as the lepton and baryon asymmetries, as suggested by the similar sizes of the observed baryonic and dark matter energy content, and provide a definite prediction for the mass of the dark matter particle. We discuss in detail a minimal realization in which the Standard Model is only extended by dark matter fermions which form "dark baryons" through an SU(3) interaction, and a (broken) horizontal symmetry that induces the new sphalerons. The dark matter mass is predicted to be approximately 6 GeV, close to the region favored by DAMA and CoGeNT. Furthermore, a remnant of the horizontal symmetry should be broken at a lower scale and can also explain the Tevatron dimuon anomaly.Comment: Minor changes, discussion of present constraints expanded. 16 pages, 2 eps figures, REVTeX

Reconstructing the Christian Malford ecosystem in the Oxford Clay Formation (Callovian, Jurassic) of Wiltshire: exceptional preservation, taphonomy, burial and compaction

&lt;p&gt;&lt;strong&gt;Abstract.&lt;/strong&gt; The Christian Malford lagerstätte in the Oxford Clay Formation of Wiltshire contains exceptionally well-preserved squid-like cephalopods, including &lt;i&gt;Belemnotheutis antiquus&lt;/i&gt; (Pearce). Some of these fossils preserve muscle tissue, contents of ink sacks and other soft parts of the squid, including arms with hooks in situ and the head area with statoliths (ear bones) present in life position. The preservation of soft-tissue material is usually taken as an indication of anoxic or dysaerobic conditions on the sea floor and within the enclosing sediments. Interestingly, in the prepared residues of all these sediments there are both statoliths and arm hooks as well as abundant, species-rich, assemblages of both foraminifera and ostracods. Such occurrences appear to be incompatible with an interpretation of potential sea floor anoxia.&lt;/p&gt; &lt;p&gt;The mudstones of the Oxford Clay Formation may have been compacted by 70&amp;amp;thinsp;%–80&amp;amp;thinsp;% during de-watering and burial, and in such a fine-grained lithology samples collected for microfossil examination probably represent several thousand years and, therefore, a significant number of foraminiferal life cycles. Such samples (even if only 1–2&amp;amp;thinsp;cm thick) could, potentially, include several oxic–anoxic cycles and, if coupled with compaction, generate the apparent coincidence of well-preserved, soft-bodied, cephalopods and diverse assemblages of benthic foraminifera.&lt;/p&gt; </jats:p

Dynamical Boson Stars

The idea of stable, localized bundles of energy has strong appeal as a model for particles. In the 1950s John Wheeler envisioned such bundles as smooth configurations of electromagnetic energy that he called {\em geons}, but none were found. Instead, particle-like solutions were found in the late 1960s with the addition of a scalar field, and these were given the name {\em boson stars}. Since then, boson stars find use in a wide variety of models as sources of dark matter, as black hole mimickers, in simple models of binary systems, and as a tool in finding black holes in higher dimensions with only a single killing vector. We discuss important varieties of boson stars, their dynamic properties, and some of their uses, concentrating on recent efforts.Comment: 79 pages, 25 figures, invited review for Living Reviews in Relativity; major revision in 201

Extrinsic primary afferent signalling in the gut

Visceral sensory neurons activate reflex pathways that control gut function and also give rise to important sensations, such as fullness, bloating, nausea, discomfort, urgency and pain. Sensory neurons are organised into three distinct anatomical pathways to the central nervous system (vagal, thoracolumbar and lumbosacral). Although remarkable progress has been made in characterizing the roles of many ion channels, receptors and second messengers in visceral sensory neurons, the basic aim of understanding how many classes there are, and how they differ, has proven difficult to achieve. We suggest that just five structurally distinct types of sensory endings are present in the gut wall that account for essentially all of the primary afferent neurons in the three pathways. Each of these five major structural types of endings seems to show distinctive combinations of physiological responses. These types are: 'intraganglionic laminar' endings in myenteric ganglia; 'mucosal' endings located in the subepithelial layer; 'muscular–mucosal' afferents, with mechanosensitive endings close to the muscularis mucosae; 'intramuscular' endings, with endings within the smooth muscle layers; and 'vascular' afferents, with sensitive endings primarily on blood vessels. 'Silent' afferents might be a subset of inexcitable 'vascular' afferents, which can be switched on by inflammatory mediators. Extrinsic sensory neurons comprise an attractive focus for targeted therapeutic intervention in a range of gastrointestinal disorders.Australian National Health and Medical Research Counci

Hunter-Gatherer Children’s Close-Proximity Networks: Similarities and differences with cooperative and communal breeding systems

Among vertebrates, allomothering (non-maternal care) is classified as cooperative breeding (help from sexually mature non-breeders, usually close relatives) or communal breeding (shared care between multiple breeders who are not necessarily related). Humans have been described with both labels, most frequently as cooperative breeders. However, few studies have quantified the relative contributions of allomothers according to whether they are a) sexually mature and reproductively active, and b) related or unrelated. We constructed close-proximity networks of Agta and BaYaka hunter-gatherers. We used portable remote-sensing devices to quantify the proportion of time children under the age of four spent in close proximity to different categories of potential allomother. Both related and unrelated, and reproductively active and inactive campmates had substantial involvement in children’s close - proximity networks. Unrelated campmates, siblings and subadults were the most involved in both populations; whereas, the involvement of fathers and grandmothers was the most variable between the two populations. Finally, the involvement of sexually mature, reproductively inactive adults was low. Where possible, we compared our findings to studies of other hunter-gatherer societies, and observed numerous consistent trends. Based on our results we discuss why hunter-gatherer allomothering cannot be fully characterised as cooperative or communal breeding

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin

Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens. Trueperella pyogenes causes tissue pathology in many mammals by secreting a cholesterol-dependent cytolysin, pyolysin (PLO), which targets stromal cells. Cellular cholesterol is derived from squalene, which is synthesized via the mevalonate pathway enzymes, including HMGCR, FDPS and FDFT1. The present study tested the hypothesis that inhibiting enzymes in the mevalonate pathway to reduce cellular cholesterol increases the resilience of stromal cells to PLO. We first verified that depleting cellular cholesterol with methyl-β-cyclodextrin increased the resilience of stromal cells to PLO. We then used siRNA to deplete mevalonate pathway enzyme gene expression, and used pharmaceutical inhibitors, atorvastatin, alendronate or zaragozic acid to inhibit the activity of HMGCR, FDPS and FDFT1, respectively. These approaches successfully reduced cellular cholesterol abundance, but mevalonate pathway enzymes did not affect cellular resilience equally. Inhibiting FDFT1 was most effective, with zaragozic acid reducing the impact of PLO on cell viability. The present study provides evidence that inhibiting FDFT1 increases stromal cell resilience to a cholesterol-dependent cytolysin