Crustal structure and the mechanism of extension in the northern Red Sea: Constraints from gravity anomalies

Gravity data from detailed marine surveys were used to investigate the density structure of the crust and upper mantle beneath the northern Red Sea, a continental rift considered by many to be in the process of establishing a mid-ocean ridge type spreading center. A gravity and bathymetry profile across the sea near 27°N was analyzed in detail. Model constraints include single-channel and multichannel seismic reflection lines coincident with the gravity profile, which provide detailed information on sedimentary layers, a series of ESP seismic experiments centered nearly on the gravity line which constrain the sediment and crustal thickness, and a series of 58 closely spaced heat flow measurements nearly coincident with the gravity line which closely constrain the mantle thermal structure and thus density variations within the mantle. The calculated gravity anomalies based on the known crustal and mantle structure fail to match the observed data. Specifically, the model anomalies become steadily more negative from the margins toward the center of the sea with the result that the calculated gravity is approximately 25 mGal more negative near the axis relative to the marginal areas than are the observed anomalies. Two possible solutions were investigated. One is to introduce a lower crustal layer resulting from crustal underplating within what was originally considered to be the upper mantle beneath the marginal areas. The other is to introduce an area of slightly denser crust resulting from intrusion of new mafic crustal material within the axial depression. Both solutions can reproduce the observed gravity anomalies within the Red Sea. However, the complete set of geophysical data, and in particular the heat flow in the Red Sea and gravity and seismic refraction data on land, suggests that the most satisfactory model is that the crust of the axial depression is denser than that of the marginal areas. This implies that crustal extension in the northern Red Sea is presently occurring in large part by intrusion of new mafic material

Pharmacogenetics and Tramadol-Related Fatalities

Tramadol (TR) is a widely prescribed pain killer because of its relatively safe profile among opioids. Nevertheless, intoxication can occur and overdose can lead to fatal outcomes. Surprisingly, in some fatalities for which death is attributable to TR alone, postmortem blood concentration levels overlap with the therapeutic concentration range. These fatal cases might be explained by pharmacokinetic and pharmacodynamic properties of TR that are known to be both enantioselective and influenced by genes. Indeed pharmacogenetics (PG) is of great importance in this issue as it has the ability to elucidate the genetic variation contributing to drug absorption, distribution, metabolism, excretion, and response so that adverse drug reactions, toxicity, and even death can be avoided. The aim of this chapter is to present this issue

Redistribution post-mortem des antiepileptiques chez le lapin (influence du pKa sur les phénomènes de redistribution post-mortem)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

L'Ethyl-glucuronide, marqueur de l'éthylisme (mise au point du dosage dans les cheveux et applications)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Les substances de soumission chimique

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Stratégie analytique lors de la prise en charge des cas de soumission chimique

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Les substances psychoactives et l'univers musical (sources d'inspiration et d'abus)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Drogues de synthèse, anciennes et nouvelles, utilisées aujourd'hui en milieux festifs

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Prise en charge d'investigations toxicologiques dans le domaine de la soumission chimique (bilan d'activité du service de pharmacologie et toxicologie du CHU de Limoges entre 2003 et 2006)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Les étapes préanalytique et postanalytique du processus d'expertise toxicologique médico-légale (référentiels applicables)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF