Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls. We directly implicate ten genes in general onset CD for the first time to our knowledge via association to coding variation, four of which lie within established CD GWAS loci. In nine instances, a single coding variant is significantly associated, and in the tenth, ATG4C, we see additionally a significantly increased burden of very rare coding variants in CD cases. In addition to reiterating the central role of innate and adaptive immune cells as well as autophagy in CD pathogenesis, these newly associated genes highlight the emerging role of mesenchymal cells in the development and maintenance of intestinal inflammation.Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn's disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Advances in Drainage: Selected Works from the Tenth International Drainage Symposium

This article introduces a special collection of fourteen articles accepted from among the 140 technical presentations, posters, and meeting papers presented at the 10th International ASABE Drainage Symposium. The symposium continued in the tradition of previous symposia that began in 1965 as a forum for presenting and assessing the progress of drainage research and implementation throughout the world. The articles in this collection address a wide range of topics grouped into five broad categories: (1) crop response, (2) design and management, (3) hydrology and scale, (4) modeling, and (5) water quality. The collection provides valuable information for scientists, engineers, planners, and others working on crop production, water quality, and water quantity issues affected by agricultural drainage. The collection also provides perspectives on the challenges of increasing agricultural production in a changing climate, with ever-greater attention to water quality and quantity concerns that will require integrated technical, economic, and social solutions.This article is published as Strock, Jeffrey S., Christopher Hay, Matthew J. Helmers, Kelly A. Nelson, Gary R. Sands, R. Wayne Skaggs, and Kyle R. Douglas-Mankin. "Advances in drainage: Selected works from the Tenth international drainage symposium." Transactions of the ASABE 61, no. 1 (2018): 161-168. DOI: 10.13031/trans.12668. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted

Advances in Drainage: Selected Works from the Tenth International Drainage Symposium

This article introduces a special collection of fourteen articles accepted from among the 140 technical presentations, posters, and meeting papers presented at the 10th International ASABE Drainage Symposium. The symposium continued in the tradition of previous symposia that began in 1965 as a forum for presenting and assessing the progress of drainage research and implementation throughout the world. The articles in this collection address a wide range of topics grouped into five broad categories: (1) crop response, (2) design and management, (3) hydrology and scale, (4) modeling, and (5) water quality. The collection provides valuable information for scientists, engineers, planners, and others working on crop production, water quality, and water quantity issues affected by agricultural drainage. The collection also provides perspectives on the challenges of increasing agricultural production in a changing climate, with ever-greater attention to water quality and quantity concerns that will require integrated technical, economic, and social solutions.This article is published as Strock, Jeffrey S., Christopher Hay, Matthew J. Helmers, Kelly A. Nelson, Gary R. Sands, R. Wayne Skaggs, and Kyle R. Douglas-Mankin. "Advances in drainage: Selected works from the Tenth international drainage symposium." Transactions of the ASABE 61, no. 1 (2018): 161-168. DOI: 10.13031/trans.12668. Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted