Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Results analysis of agricultural organizations subsidy

The article presents some issues of the methodology of the study of state support for agricultural production in the aspect of efficiency. The dynamic series of profitability for certain types of products sold by agricultural organizations with and without budget subsidies are used as source data. First, a preliminary analysis and pairwise comparison of the series using nonparametric methods is carried out. Further, in order to use complete information on all the data, the methods of reduction to three variables are applied. In order to compare different methods, the principal component method and autoencoding using a neural network were used. The transformed data was also compared with and without subsidies. Conclusions and practical recommendations on the results obtained, as well as directions for the development of scientific research, are formulated