180 research outputs found
Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats
Get PDFInsulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension. Along the insulin signaling pathway, the insulin receptor substrates 1 and 2 (IRS-1 and -2) are important mediators of insulin signaling. IRS-1 and/or IRS-2 genetic variant(s) and/or enhanced serine phosphorylation correlate with insulin resistance. The present commentary was designed to highlight the significance of IRS-1 and/or -2 in the pathogenesis of insulin resistance. An emphasis will be given to the putative role of IRS-1 and/or -2 genetic variant(s) and serine phosphorylation in precipitating insulin resistance
Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment
Full text linkExploiting natural variation to improve the content and composition of dietary fibre in wheat grain: A review
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Evidence that insulin deficiency in the rat has disparate effects on fructose 2,6- biphosphate levels in muscle and liver.
No full textAbnormal lipid metabolism in treated hypertensive patients with non-insulin- dependent diabetes mellitus.
No full textSpecific binding and degradation (d) of 125i-rat high density lipoprotein (hdl) by purified rat leydig cells (LC).
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