1,141 research outputs found
The meaning of patient involvement and participation in health care consultations: a taxonomy
Artikkelen undersÞker hva brukermedvirkning kan vÊre.Deltakelse blir sett pÄ noe som co-bestemmes av pasienter og fagfolk, og forekommer bare gjennom gjensidige relasjoner for dialog og felles beslutninger. Ikke alle pasienter Þnsket Ä vÊre involvert, og i hvilken grad involvering ble Þnsket avhengig av type og alvorlighetsgrad av sykdom, ulike personlige egenskaper og pasientenes relasjoner med fagfolk. Disse nivÄene er sett som grunnleggende byggesteiner for en mer sofistikert forstÄelse av brukermedvirkning innenfor og mellom disse sammenhenger for bruk av fagfolk, ledere, beslutningstakere og forskere
Coping styles associated with depression, health anxiety and health-related quality of life in pulmonary hypertension : cross-sectional analysis
Objectives
Pulmonary hypertension (PH) is a life-shortening disease associated with early mortality and high morbidity. With advancements in medical treatment, people are living longer with the disease, and research is now needed to explore variables that help to enhance patient-reported outcomes. This study investigated the coping strategies of individuals with PH and examined the relationship between coping, depression, health anxiety and health-related quality of life (HRQoL).
Design
A cross-sectional survey design was used.
Participants
Participants (n=121) were recruited from membership of Pulmonary Hypertension Association (PHA) UK.
Outcome measures
Participants completed a series of questionnaires assessing depression (Patient Health Questionnaire-9), health anxiety (Short Health Anxiety Inventory), HRQoL (emPHasis-10) and coping (Brief COPE). A principal component analysis was used to identify participantsâ coping profile. A series of correlational, linear and moderated multiple regression analyses were performed to examine the relationship between coping and health-related outcomes.
Results
Overall, 43% participants met criteria for potential clinical depression. Depression and health anxiety were strongly associated with HRQoL, explaining 37% and 30% of variance respectively (p<0.001). A principal component analysis identified a four-component model of coping. Dimensions were named based on construct items: âcognitive and affirmation copingâ (seven items), âpassive copingâ (four items), âexternal copingâ (seven items) and âsubstance use copingâ (two items). Cognitive and affirmation and external coping moderated the relationship between depression and HRQoL, with high use of these coping strategies reducing the impact of depression on HRQoL. External coping also moderated the effect of health anxiety on HRQoL.
Conclusions
The results uniquely highlight the importance of coping styles and psychological distress in predicting HRQoL in PH. Our findings indicate the importance to assess for psychological distress in this population and suggest the need to offer psychological interventions that take into account coping resources and strategies
A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor
Morphological changes leading to aerial mycelium formation and sporulation in the mycelial bacterium Streptomyces coelicolor rely on establishing distinct patterns of gene expression in separate regions of the colony. sH was identified previously as one of three paralogous sigma factors associated with stress responses in S. coelicolor. Here, we show that sigH and the upstream gene prsH (encoding a putative antisigma factor of sH) form an operon transcribed from two developmentally regulated promoters, sigHp1 and sigHp2. While sigHp1 activity is confined to the early phase of growth, transcription of sigHp2 is dramatically induced at the time of aerial hyphae formation. Localization of sigHp2 activity using a transcriptional fusion to the green fluorescent protein reporter gene (sigHp2âegfp) showed that sigHp2 transcription is spatially restricted to sporulating aerial hyphae in wild-type S. coelicolor. However, analysis of mutants unable to form aerial hyphae (bld mutants) showed that sigHp2 transcription and sH protein levels are dramatically upregulated in a bldD mutant, and that the sigHp2âegfp fusion was expressed ectopically in the substrate mycelium in the bldD background. Finally, a protein possessing sigHp2 promoter-binding activity was purified to homogeneity from crude mycelial extracts of S. coelicolor and shown to be BldD. The BldD binding site in the sigHp2 promoter was defined by DNase I footprinting. These data show that expression of sH is subject to temporal and spatial regulation during colony development, that this tissue-specific regulation is mediated directly by the developmental transcription factor BldD and suggest that stress and developmental programmes may be intimately connected in Streptomyces morphogenesis
Adultsâ experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies
Objectives Pulmonary hypertension is a life-shortening disease that has a considerable impact on quality of life. Improving our understanding of how individuals are affected and cope with the disease will help to improve services and outcomes. This review synthesises the published qualitative research that has listened to adults discuss their experiences of living with the disease.
Design A comprehensive systematic search of four databases was conducted in May 2020: Web of Science, PubMed, PsycINFO and Cochrane Library. Suitable studies were evaluated using the Critical Appraisal Skills programme. Findings from the studies were extracted and subjected to a thematic synthesis.
Results Nineteen articles were identified reflecting the experiences of over 1900 individuals impacted by pulmonary hypertension from Europe, North and South America and Asia. Ten studies did not report participantâs WHO functional class of pulmonary hypertension, which resulted in comparing experiences between different severity difficult. All studies met the majority of the quality assessment items. Six descriptive themes emerged discussing participantâs experiences of diagnosis, treatment, prognosis, healthcare professionals, impact and coping with pulmonary hypertension. Four higher order analytical themes were developed from the descriptive themes, reflecting: (i) uncertainties and anxiety that participants encountered related to pulmonary hypertension; (ii) lack of recognition of the impact of the condition; (iii) frustration at the paucity of awareness of pulmonary hypertension in society and healthcare settings and (iv) participantâs accounts of transitioning through different stages of living with the disease.
Conclusions These findings form the first synthesis of experiences of life in individuals impacted by pulmonary hypertension and illustrate the multifaceted impact of the condition. The voices of numerous groups are missing from the literature highlighting the need for additional research. The results have implications for clinical practice emphasising the role of educational and psychological therapies to support those with the disease
Production and processing studies on calpain-system gene markers for tenderness in Brahman cattle: 2. Objective meat quality
Effects and interactions of calpain-system tenderness gene markers on objective meat quality traits of Brahman (Bos indicus) cattle were quantified within 2 concurrent experiments at different locations. Cattle were selected for study from commercial and research herds at weaning based on their genotype for cal-pastatin (CAST) and calpain 3 (GAPN3) gene markers for beef tenderness. Gene marker status for i-calpain (CAPN1-4751 and CAPN1-316) was also determined for inclusion in statistical analyses. Eighty-two heifer and 82 castrated male cattle with 0 or 2 favorable alleles for CAST and CAPN3 were studied in New South Wales (NSW), and 143 castrated male cattle with 0, 1, or 2 favorable alleles for CAST and CAPN3 were studied in Western Australia (WA). The cattle were backgrounded for 6 to 8 mo and grain-fed for 117 d (NSW) or 80 d (WA) before slaughter. One-half the cattle in each experiment were implanted with a hormonal growth promotant during feedlotting. One side of each carcass was suspended from the Achilles tendon (AT) and the other from the pelvis (tenderstretch). The M. longissimus lumborum from both sides and the M. semitendinosus from the AT side were collected; then samples of each were aged at 1°C for 1 or 7 d. Favorable alleles for one or more markers reduced shear force, with little effect on other meat quality traits. The size of effects of individual markers varied with site, muscle, method of carcass suspension, and aging period. Individual marker effects were additive as evident in cattle with 4 favorable alleles for CAST and CAPN3 markers, which had shear force reductions of 12.2 N (P 0.05) of interactions between the gene markers, or between the hormonal growth promotant and gene markers for any meat quality traits. This study provides further evidence that selection based on the CAST or CAPN3 gene markers improves meat tenderness in Brahman cattle, with little if any detrimental effects on other meat quality traits. The CAPN1-4751 gene marker also improved beef tenderness without affecting other objective meat quality traits in heterozygous cattle compared with homozygotes for the unfavorable allele
The valence-fluctuating ground state of plutonium
A central issue in material science is to obtain understanding of the electronic correlations that control complex materials. Such electronic correlations frequently arise because of the competition of localized and itinerant electronic degrees of freedom. Although the respective limits of well-localized or entirely itinerant ground states are well understood, the intermediate regime that controls the functional properties of complex materials continues to challenge theoretical understanding. We have used neutron spectroscopy to investigate plutonium, which is a prototypical material at the brink between bonding and nonbonding configurations. Our study reveals that the ground state of plutonium is governed by valence fluctuations, that is, a quantum mechanical superposition of localized and itinerant electronic configurations as recently predicted by dynamical mean field theory. Our results not only resolve the long-standing controversy between experiment and theory on plutoniumâs magnetism but also suggest an improved understanding of the effects of such electronic dichotomy in complex materials.JRC.E.6-Actinide researc
What is the Nature of EUV Waves? First STEREO 3D Observations and Comparison with Theoretical Models
One of the major discoveries of the Extreme ultraviolet Imaging Telescope
(EIT) on SOHO were intensity enhancements propagating over a large fraction of
the solar surface. The physical origin(s) of the so-called `EIT' waves is still
strongly debated. They are considered to be either wave (primarily fast-mode
MHD waves) or non-wave (pseudo-wave) interpretations. The difficulty in
understanding the nature of EUV waves lies with the limitations of the EIT
observations which have been used almost exclusively for their study. Their
limitations are largely overcome by the SECCHI/EUVI observations on-board the
STEREO mission. The EUVI telescopes provide high cadence, simultaneous
multi-temperature coverage, and two well-separated viewpoints. We present here
the first detailed analysis of an EUV wave observed by the EUVI disk imagers on
December 07, 2007 when the STEREO spacecraft separation was .
Both a small flare and a CME were associated with the wave cadence, and single
temperature and viewpoint coverage. These limitations are largely overcome by
the SECCHI/EUVI observations on-board the STEREO mission. The EUVI telescopes
provide high cadence, simultaneous multi-temperature coverage, and two
well-separated viewpoints. Our findings give significant support for a
fast-mode interpretation of EUV waves and indicate that they are probably
triggered by the rapid expansion of the loops associated with the CME.Comment: Solar Physics, 2009, Special STEREO Issue, in pres
Self-consistent Green's function approaches
We present the fundamental techniques and working equations of many-body
Green's function theory for calculating ground state properties and the
spectral strength. Green's function methods closely relate to other polynomial
scaling approaches discussed in chapters 8 and 10. However, here we aim
directly at a global view of the many-fermion structure. We derive the working
equations for calculating many-body propagators, using both the Algebraic
Diagrammatic Construction technique and the self-consistent formalism at finite
temperature. Their implementation is discussed, as well as the inclusion of
three-nucleon interactions. The self-consistency feature is essential to
guarantee thermodynamic consistency. The pairing and neutron matter models
introduced in previous chapters are solved and compared with the other methods
in this book.Comment: 58 pages, 14 figures, Submitted to Lect. Notes Phys., "An advanced
course in computational nuclear physics: Bridging the scales from quarks to
neutron stars", M. Hjorth-Jensen, M. P. Lombardo, U. van Kolck, Editor
Projective dynamics and first integrals
We present the theory of tensors with Young tableau symmetry as an efficient
computational tool in dealing with the polynomial first integrals of a natural
system in classical mechanics. We relate a special kind of such first
integrals, already studied by Lundmark, to Beltrami's theorem about
projectively flat Riemannian manifolds. We set the ground for a new and simple
theory of the integrable systems having only quadratic first integrals. This
theory begins with two centered quadrics related by central projection, each
quadric being a model of a space of constant curvature. Finally, we present an
extension of these models to the case of degenerate quadratic forms.Comment: 39 pages, 2 figure
(Sub)mm Interferometry Applications in Star Formation Research
This contribution gives an overview about various applications of (sub)mm
interferometry in star formation research. The topics covered are molecular
outflows, accretion disks, fragmentation and chemical properties of low- and
high-mass star-forming regions. A short outlook on the capabilities of ALMA is
given as well.Comment: 20 pages, 7 figures, in proceedings to "2nd European School on Jets
from Young Star: High Angular Resolution Observations". A high-resolution
version of the paper can be found at
http://www.mpia.de/homes/beuther/papers.htm
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