Identification of specificity H-2.7 as an erythrocyte antigen: Control by an independent locus, H-2G , between the S and D regions

Specificity H-2.7 is expressed predominantly on erythrocytes and controlled by a gene that maps within the H-2 gene complex at a locus, designated as H-2G , which apparently lies between regions S and D . Three phenotypes have been observed with respect to this antigen: a) positive by direct test and absorption (haplotypes H-2 f , H-2 j , H-2 p , H-2 s ); b) positive only by absorption ( H-2 k ); and c) negative ( H-2 b , H-2 d , H-2 q ). New crossover positions have been established for several H-2 recombinants based on classifications for the H-2G locus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46742/1/251_2005_Article_BF01572281.pd

Salinity tolerance of diapausing eggs of freshwater zooplankton

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73091/1/j.1365-2427.2004.01185.x.pd

Linkage in mice of genes controlling an immunoglobulin kappa-chain marker and the surface alloantigen Ly-3 on T lymphocytes

Evidence obtained using recombinant inbred and congenic mouse strains has shown that the PC8 locus responsible for determining a marker on a single k chain in inbred mice is linked to the Ly - 2,3 locus on chromosome 6. The upper limit of the map distance between these loci is approximately three centimorgans. This finding is discussed in relation to other known light-chain variants that are associated with the Ly - 2,3 locus.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46753/1/251_2005_Article_BF01563929.pd

Living instruments and theoretical terms : Xenografts as measurements in cancer research

I discuss the relationship between theoretical terms and measuring devices using a very peculiar example from biomedical research: cancer transplantation models. I do so through two complementary comparisons. I first show how a historical case study can shed light on a similar case from contemporary biomedical research. But I also compare both to a paradigmatic case of measurement in the physical sciences -- thermometry -- which reveals some of the most relevant epistemological issues. The comparison offers arguments for the recent debate on the operational definition of Cancer Stem Cells, and thereby suggests the relevance of a comparative approach in the history and philosophy of science

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York