The development of iHARP: a multiple instruction issue processor chip

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.---- Copyright IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.During the last decade RISC ideas on processor architecture have become widely accepted. RISC architectures achieve significant performance advantages over CISC architectures by striving to execute one instruction per cycle. However, a traditional RISC architemre can never execute more than one instruction per cycle. Achieving further performance improvements beyond RISC depends on developing processors which fetch and execute more than one operation in each processor cycle.Final Accepted Versio

The relation between accretion rate and jet power in X-ray luminous elliptical galaxies

Using Chandra X-ray observations of 9 nearby, X-ray luminous ellipticals with good optical velocity dispersion measurements, we show that a tight correlation exists between the Bondi accretion rates calculated from the X-ray data and estimated black hole masses, and the power emerging from these systems in relativistic jets. The jet powers, inferred from the energies and timescales required to inflate the cavities observed in the surrounding X-ray emitting gas, can be related to the accretion rates by a power law model. A significant fraction (2.2^{+1.0}_{-0.7} per cent, for P_jet=10^{43} erg/s) of the energy associated with the rest mass of material entering the accretion radius eventually emerges in the jets. The data also hint that this fraction may rise slightly with increasing jet power. Our results have significant implications for studies of accretion, jet formation and galaxy formation. The tight correlation between P_Bondi and P_jet suggests that the Bondi formulae provide a reasonable description of the accretion process, despite the likely presence of magnetic pressure and angular momentum in the accreting gas, and that the accretion flows are approximately stable over timescales of a few million years. Our results show that the black hole `engines' at the hearts of large elliptical galaxies and groups can feed back sufficient energy to stem cooling and star formation, leading naturally to the observed exponential cut off at the bright end of the galaxy luminosity function.Comment: Accepted for publication in MNRAS. 10 pages, 4 figures. Includes an enhanced statistical analysis and some additional data. Conclusions unchange

Elliptic Flow of Identified Hadrons in Au+Au Collisions at sqrt(s_NN) = 200 GeV

The anisotropy parameter v_2, the second harmonic of the azimuthal particles distribution, has been measured with the PHENIX detector in Au+Au collisions at sqrt(s_NN) = 200 GeV for identified and inclusive charged particles at central rapidities (|eta| < 0.35) with respect to the reaction plane defined at high rapidities (|eta| = 3-4). The v_2 for all particles reaches a maximum at mid-centrality, and increases with p_T up to 2 GeV/c and then saturates or decreases slightly. Our results depart from hydrodynamically predicted behavior above 2 GeV/c. A quark coalescence model is also investigated.Comment: 325 authors, 6 pages text, RevTeX, 3 figures, 0 tables. This version accepted for publication in Phys. Rev. Lett. after minor changes in response to referee suggestions. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are publicly available at http://www.phenix.bnl.gov/papers.htm

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Delayed branches versus dynamic branch prediction in a high-performance superscalar architecture

While delayed branch mechanisms were popular with the designers of RISC processors, most superscalar processors deploy dynamic branch prediction to minimise run-time branch penalties. We propose a generalised branch delay mechanism that is more suited to superscalar processors. We then quantitatively compare the performance of our delayed branch mechanism with run-time branch prediction, in the context of a high-performance superscalar architecture that uses aggressive compile-time instruction scheduling

A Parallel Pipelined Processor with Conditional Instruction Execution

In a recent paper by Smith, Lam and Horowitz [1] the concept of 'boosting' was introduced, where instructions from one of the possible instruction streams following a conditional branch were scheduled by the compiler for execution in the basic block containing the branch itself. This paper describes how code from both instruction streams following a conditional branch can be considered for execution in the basic block containing the branch. Branch conditions are stored in Boolean registers and all instructions are conditionally executed based on the value in a Boolean register. The two instruction streams can therefore be executed on complementary values of the same Boolean register.Peer reviewe

A cost-effective two-level adaptive branch predictor

Peer reviewe