M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT

The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions

They Come over Here … 300 Years of Xenophobic Propaganda in England

England's rulers, merchants, and organized labor in the early modern period (from the 16th to the 18th centuries) were all actively using what today we would call propaganda. Each group appreciated the need to get popular opinion on its side, or at the least to convince other groups it was in the public interest to act in a particular way. This study focuses on the use of xenophobic narratives by these actors in order to further their political, economic, or cultural objectives. The targets were economic rivals including the Dutch, but most particularly ethnic and religious outgroups, including Roman Catholics, Muslims, and Jews. Although there were public relations win-wins for anyone who was able successfully to demonize foreigners, racist and xenophobic propaganda was often more pernicious than the tellers realized, in many cases extending its influence over several generations. In addition, it is clear that many narratives failed to engage with public opinion, for reasons that were not always clear to the groups responsible for them