Conceptual model of E. coli transcriptional machinery

At the moment one type of analysis of transcription regulatory networks (TRNs) in prokaryotes is topological analysis of graph structure of possible regulatory interaction links (see for example [1]). That type of analysis takes into account possibility links that designate the fact that one gene product in some conditions can modulate transcription of the other. The benefit of such approach is that it is allow analyzing TRN at the whole cell level. At the same type it is known that at least some responses are regulated by abundance of elements of transcription machinery [2-3]. We have developed conceptual model of whole cell E. coli TRN with SBGN ER, SBGN PD and SBGN AF languages [4]. That model is the first step towards incorporation of some quantitative information into whole cell TRN modeling.

1.	Freyre-González et al. Functional architecture of Escherichia coli: new insights provided by a natural decomposition approach. Genome Biol (2008) vol. 9 (10) pp. R154
2.	Klumpp and Hwa. Growth-rate-dependent partitioning of RNA polymerases in bacteria. Proc Natl Acad Sci USA (2008) vol. 105 (51) pp. 20245-50
3.	Barker et al. Mechanism of regulation of transcription initiation by ppGpp. II. Models for positive control based on properties of RNAP mutants and competition for RNAP. J Mol Biol (2001) vol. 305 (4) pp. 689-702
4.	Le Novère et al. The systems biology graphical notation. Nature biotechnology (2009) vol. 27 (8) pp. 735-41
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Method for influencing the development of elderly education in Russia

The paper discusses the problem of mass education for the elderly in Russia. To deal with this issue, we ground the expediency of using the resources of non-formal education projects for senior citizens. We analyze the totality of specialized educational projects implemented in the country as a social network, i.e. a specific self-organized object resistant to external management. The article presents the results of an online survey of experts (organizers of education projects for senior citizens and researchers on the problems of elderly education). Based on the respondents’ answers, the research concludes about the specificity of the elderly education network as an object of management and analyzes the possibility to adopt centralized educational management. The paper formulates the general principles and techniques of management in the field of elderly education in Russia and provides the authors’ method to control the development of elderly education projects in the country

Scenarios for the Development of Elderly Education in Russia

The paper delves into the problem of mass education for senior citizens in Russia and assesses the capabilities of the country’s system of non-formal elderly education to overcome this problem. It proves the expediency to use the resources of the national education network in social management strategies aimed at increasing the educational level of the older generation. The research demonstrates that it is necessary to purposefully manage the national network of elderly education and forecast the outcome of such an influence. Having analyzed specialized elderly education projects, the authors identify the trends in the functioning of elderly education in Russia and establish the factors in its development. The study provides forecast scenarios for the development of elderly education. Summarizing the scenarios presented, it is worth noting that the government policy will have a decisive effect on the system of elderly education. Undoubtedly, education for senior citizens in Russia will undergo rapid development due to favorable conditions in the country

Hyperfine structure of S-states in muonic deuterium

On the basis of quasipotential method in quantum electrodynamics we calculate corrections of order $\alpha^5$ and $\alpha^6$ to hyperfine structure of S-wave energy levels of muonic deuterium. Relativistic corrections, effects of vacuum polarization in first, second and third orders of perturbation theory, nuclear structure and recoil corrections are taken into account. The obtained numerical values of hyperfine splitting $\Delta E^{hfs}(1S)=50.2814$ meV (1S state) and $\Delta E^{hfs}(2S)=6.2804$ meV (2S state) represent reliable estimate for a comparison with forthcoming experimental data of CREMA collaboration. The hyperfine structure interval $\Delta_{12}=8\Delta E^{hfs}(2S)-\Delta E^{hfs}(1S)=-0.0379$ meV can be used for precision check of quantum electrodynamics predictions for muonic deterium.Comment: 18 pages, 7 figure

Exploring the S-Matrix of Massless Particles

We use the recently proposed generalised on-shell representation for scattering amplitudes and a consistency test to explore the space of tree-level consistent couplings in four-dimensional Minkowski spacetime. The extension of the constructible notion implied by the generalised on-shell representation, i.e. the possibility to reconstruct at tree level all the scattering amplitudes from the three-particle ones, together with the imposition of the consistency conditions at four-particle level, allow to rediscover all the known theories and their algebra structure, if any. Interestingly, this analysis seems to leave room for high-spin couplings, provided that at least the requirement of locality is weakened. We do not claim to have found tree-level consistent high-spin theories, but rather that our methods show signatures of them and very likely, with a suitable modification, they can be a good framework to perform a systematic search.Comment: 44 pages, 1 figur