Mothers and fathers with Binge Eating Disorder and their 18-36 months old children: a longitudinal study on parent-infant interactions and offspring\u2019s emotional-behavioral profiles

Maternal Binge Eating Disorder (BED) has been suggested to be associated with poor parent\u2013infant interactions during feeding and with children\u2019s emotional and behavioral problems during infancy (Blissett and Haycraft, 2011). The role of fathers has received increasing consideration in recent years, yet the research has not focused on interactional patterns between fathers with BED and their children. The present study aimed to longitudinally investigate the in\ufb02uence of BED diagnosis, in one or both parents, on parent\u2013infant feeding interactions and on children\u2019s emotional\u2013behavioral functioning. 612 subjects (408 parents; 204 children), recruited in mental health services and pre-schools in Central Italy, were divided into four groups: Group 1 included families with both parents diagnosed with BED, Group 2 and 3 included families with one parent diagnosed with BED, Group 0 was a healthy control. The assessment took place at T1 (18 months of age of children) and T2 (36 months of age of children): feeding interactions were assessed through the Scale for the Assessment of Feeding Interactions (SVIA) while child emotional\u2013behavioral functioning was evaluated with the Child Behavior Check-List (CBCL). When compared to healthy controls, the groups with one or both parents diagnosed with BED showed higher scores on the SVIA and on the CBCL internalizing and externalizing scales, indicating poorer adult\u2013child feeding interactions and higher emotional\u2013behavioral dif\ufb01culties. A direct in\ufb02uence of parental psychiatric diagnosis on the quality of mother\u2013infant and father\u2013infant interactions was also found, both at T1 and T2. Moreover, dyadic feeding interactions mediated the in\ufb02uence of parental diagnosis on children\u2019s psychological functioning. The presence of BED diagnosis in one or both parents seems to in\ufb02uence the severity of maladaptive parent\u2013infant exchanges during feeding and offspring\u2019s emotional\u2013behavioral problems over time, consequently affecting different areas of children\u2019s psychological functioning. This is the \ufb01rst study to demonstrate the speci\ufb01c effects of maternal and paternal BED on infant development. These results could inform prevention and intervention programs in families with one or both parents diagnosed with BED

5d-5f Electric-multipole Transitions in Uranium Dioxide Probed by Non-resonant Inelastic X-ray Scattering

Non-resonant inelastic x ray scattering (NIXS) experiments have been performed to probe the 5d-5f electronic transitions at the uranium O(4,5) absorption edges in uranium dioxide. For small values of the scattering vector q, the spectra are dominated by dipole-allowed transitions encapsulated within the giant resonance, whereas for higher values of q the multipolar transitions of rank 3 and 5 give rise to strong and well-defined multiplet structure in the pre-edge region. The origin of the observed non-dipole multiplet structures is explained on the basis of many-electron atomic spectral calculations. The results obtained demonstrate the high potential of NIXS as a bulk-sensitive technique for the characterization of the electronic properties of actinide materials.Comment: Submitted to Physical Review Letters on 31 December 200

Role of Ligand Conformation on Nanoparticle-Protein Interactions

Engineered biomedical nanoparticles (NPs) administered via intravenous routes are prone to associate to serum proteins. The protein corona can mask the NP surface functionalization and hamper the delivery of the NP to its biological target. The design of corona-free NPs relies on our understanding of the chemical-physical features of the NP surface driving the interaction with serum proteins. Here, we address, by computational means, the interaction between human serum albumin (HSA) and a prototypical monolayer-protected Au nanoparticle. We show that both the chemical composition (charge, hydrophobicity) and the conformational preferences of the ligands decorating the NP surface affect the NP propensity to bind HSA

Mafia and public spending: Evidence on the fiscal multiplier from a quasi-experiment

A law issued to combat political corruption and Mafia infiltration of city councils in Italy has resulted in episodes of large, unanticipated, temporary contractions in local public spending. Using these episodes as instruments, we estimate the output multiplier of spending cuts at provincial level—controlling for national monetary and fiscal policy, and holding the tax burden of local residents constant—to be 1.5. Assuming that lagged spending is exogenous to current output brings the estimate of the overall multiplier up to 1.9. These results suggest that local spending adjustment may be quite consequential for local activity. (JEL D72, E62, H71, K42) The work on this paper is part of PEGGED (Politics, Economics and Global Governance: The European Dimensions), Contract no. SSH7-CT-2008-217559 within the seventh Framework Programme for Research and Technological Development. Support from the Pierre Werner Chair Programme at the European University Institute is also gratefully acknowledged.This is the version of record, which can also be found on the publisher's website at: http://pubs.aeaweb.org/doi/pdfplus/10.1257/aer.104.7.2185 © American Economic Associatio

The Consumption Response to Liquidity-Enhancing Transfers: Evidence from Italian Earthquakes

Exploiting three Italian earthquakes as quasi-experiments, we analyze the response of homeowners' consumption to targeted transfers, financing housing reconstruction over time. Like loans, these transfers mainly affect the liquidity of households' wealth in the short run: we show that they have no effect on consumption over a multi-year horizon. Yet, the access to reconstruction funds has significantly heterogeneous effects on impact: it strongly raises non-durable consumption by households with low liquidity and bank debt (the 'wealthy-hand-to-mouth'); it makes no difference for liquid households. Consistently, in either group, consumption is insensitive to transfer funds that accrue directly to firms

De-excitation spectroscopy of strongly interacting Rydberg gases

We present experimental results on the controlled de-excitation of Rydberg states in a cold gas of Rb atoms. The effect of the van der Waals interactions between the Rydberg atoms is clearly seen in the de-excitation spectrum and dynamics. Our observations are confirmed by numerical simulations. In particular, for off-resonant (facilitated) excitation we find that the de-excitation spectrum reflects the spatial arrangement of the atoms in the quasi one-dimensional geometry of our experiment. We discuss future applications of this technique and implications for detection and controlled dissipation schemes.Comment: 6 pages, 5 figure

Temperature dependence of iron local magnetic moment in phase-separated superconducting chalcogenide

We have studied local magnetic moment and electronic phase separation in superconducting K$_{x}$Fe$_{2-y}$Se$_2$ by x-ray emission and absorption spectroscopy. Detailed temperature dependent measurements at the Fe K-edge have revealed coexisting electronic phases and their correlation with the transport properties. By cooling down, the local magnetic moment of Fe shows a sharp drop across the superconducting transition temperature (T$_c$) and the coexisting phases exchange spectral weights with the low spin state gaining intensity at the expense of the higher spin state. After annealing the sample across the iron-vacancy order temperature, the system does not recover the initial state and the spectral weight anomaly at T$_c$ as well as superconductivity disappear. The results clearly underline that the coexistence of the low spin and high spin phases and the transitions between them provide unusual magnetic fluctuations and have a fundamental role in the superconducting mechanism of electronically inhomogeneous K$_{x}$Fe$_{2-y}$Se$_2$ system.Comment: 6 pages, 5 figure

A Martini coarse-grained model of the calcein fluorescent dye

Calcein leakage assays are a standard experimental set-up for probing the extent of damage induced by external agents on synthetic lipid vesicles. The fluorescence signal associated with calcein release from liposomes is the signature of vesicle disruption, transient pore formation or vesicle fusion. This type of assay is widely used to test the membrane disruptive effect of biological macromolecules, such as proteins, antimicrobial peptides and RNA and is also used on synthetic nanoparticles with a polymer, metal or oxide core. Little is known about the effect that calcein and other fluorescent dyes may have on the properties of lipid bilayers, potentially altering their structure and permeability. Here we develop a coarse-grained model of calcein that is compatible with the Martini force field for lipids. We validate the model by comparing its dimerization free energy, aggregation behavior at different concentrations and interaction with a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane to those obtained at atomistic resolution. Our coarse-grained description of calcein makes it suitable for the simulation of large calcein-filled liposomes and of their interactions with external agents, allowing for a direct comparison between simulations and experimental liposome leakage assays

Electric-pulse-induced reversible resistance in doped zinc oxide thin films

Nonvolatile, electric-pulse-induced resistance switching is reported on S and Co doped ZnO thin films deposited on different substrates using magnetron sputtering and laser ablation. Two resistance states were obtained by applying voltage pulses of different polarity. The switching was observed regardless of the substrate, dopant species, or microstructure of the samples. In the Co doped ZnO samples, the two resistance states are remarkably stable and uniform