23 research outputs found
Indagine statistica sui tentativi di suicidio con farmaci e con "altri mezzi" rilevati dalla P.G. del circondario di Livorno nel quadriennio 1974-1977
THE KINETIC DISPOSITION OF ERYTHROMYCIN PROPIONATE AND STEARATE IN HUMAN-PLASMA AND SALIVA
Tissue concentrations of coenzyme Q in liver of rats intoxicated by carbon tetrachloride
Pharmacokinetics of two esters of erythromycin: plasmatic and salivary levels before and after associate treatment with fosfomycin
Prediction of relapse or sustained response in biochemical responders by serum hepatitis C virus RNA monitoring during interferon therapy
The pharmacokinetic profile of clofoctol in rat plasma and tissues after oral and rectal administration.
The pharmacokinetics of clofoctol was investigated in rat plasma and tissues after both oral and rectal treatment at a single dose of 300 mg/kg. After oral administration the plasmatic peak was 2.12 +/- 0.92 microgram/ml, occurring at the 90th min, with T/2 of 121.45 +/- 23.41 min. After rectal administration a plasmatic peak of 1.97 +/- 0.61 microgram/ml was reached at the 20th min with T/2 of 41.07 +/- 12.30 min. The kinetic profile of the drug in tissues exhibited a pattern similar to that in the plasma, since the maximal peak of clofoctol in tissues following rectal administration occurred before that obtained after oral administration. Tissue concentrations significantly higher than plasmatic ones were obtained through both administration routes. The present results indicate that clofoctol is well absorbed after both oral and rectal administration; however rectal treatment produces more rapid absorption and elimination compared with oral treatment