Effect of the radiochemical impurities of 99mTc-MIBI on the diagnostic quality of the images in nuclear medicine

En este trabajo se analiza la confiabilidad del método de control de pureza radioquímica del 99mTc-MIBI utilizado en los servicios de medicina nuclear y se discute la influencia de la mayor existencia de impurezas radioquímicas en la calidad diagnóstica de las imágenes obtenidas.This work analyzes the reliability of the radiochemical purity control method of 99mTc-MIBI used in nuclear medicine services and the influence of the greater presence of radiochemical impurities in the diagnostic quality of the obtained images.Fil: Guisande Donadio, Sabrina Natali. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Sanchez, J.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Garavaglia, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Rozanskas, S.. Cimed; ArgentinaFil: Dopta, G.. Instituto de Cardiología La Plata; ArgentinaFil: Pertusi, K.. Instituto de Cardiología la Plata; ArgentinaFil: Sanz, V.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Mele, A.. Instituto de Cardiología La Plata; ArgentinaFil: Illanes, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Física; ArgentinaFil: Chain, Cecilia Yamil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentin

Multi-objective optimization of internal combustion engine by means of 1D fluid-dynamic models

The definition of an efficient optimization methodology for internal combustion engine design using 1D fluid dynamic simulation models is presented. This work aims at discussing the fundamental numerical and fluid dynamic aspects which can lead to the definition of a best practice technique, depending on the complexity of the problem to be dealt with, on the number of design parameters, objective variables and constrains. For these reasons, both single-and multi-objective problems will be addressed, where the former are still of relevant interest (i.e. optimization of engine performances), while the latter have a much wider range of applications and are often characterized by conflicting objectives. The Mesh Adaptive Direct Search (MADS) was chosen among the class of direct search methods and compared with the Genetic Algorithms to solve single-objective problems, and similarly two different algorithms were chosen and compared to solve multi-objective problems: the [epsilon]-constraint method and the NSGA-II (Non-Dominated Sorting Genetic Algorithm) A single cylinder spark ignition engine, used in a motorbike application, was chosen as test case, to allow reduced computational times, without any loss of generality of the results. The analysis evaluate the convergence and efficiency of each methodology for the different problems which are solved. The achieved goal is not the definition of an ever valid mathematical strategy, but here focus is given on the parallel application of a detailed fluid dynamic analysis and automated optimization techniques to suggest a best practice technique to be employed depending on the characteristic of the optimization problem to be solved.Multi-objective optimization Fluid dynamic model Internal combustion engine GASDYN MADS NSGA-II