1,049 research outputs found
Cardiovascular System Studies
Contains research objectives and reports on one research project.National Institutes of Health (Grant 5 TI HE 5550-03
Cardiovascular Systems
Contains report on status of researchJoint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DA 36-039-AMC-03200(E
Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand
Background: Dementia with Lewy bodies (DLB) is one of the main differential diagnoses of Alzheimer's disease (AD). Key pathological features of patients with DLB are not only the presence of cerebral cortical neuronal loss, with Lewy bodies in surviving neurones, but also loss of nigrostriatal dopaminergic neurones, similar to that of Parkinson's disease (PD). In DLB there is 40-70% loss of striatal dopamine.Objective: To determine if detection of this dopaminergic degeneration can help to distinguish DLB from AD during life.Methods: The integrity of the nigrostriatal metabolism in 27 patients with DLB, 17 with AD, 19 drug naive patients with PD, and 16 controls was assessed using a dopaminergic presynaptic ligand, I-123-labelled 2beta-carbomethoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane (FP-CIT), and single photon emission tomography (SPET). A SPET scan was carried out with a single slice, brain dedicated tomograph (SME 810) 3.5 hours after intravenous injection of 185 MBq FP-CIT. With occipital cortex used as a radioactivity uptake reference, ratios for the caudate nucleus and the anterior and posterior putamen of both hemispheres were calculated. All scans were also rated by a simple visual method.Results: Both DLB and PD patients had significantly lower uptake of radioactivity than patients with (p<0.01) and controls (p<0.001) in the caudate nucleus and the anterior and posterior Putamen.Conclusion: FP-CIT SPET provides a means of distinguishing DLB from AD during life
Cardiovascular System Studies
Contains reports on two research projects.National Institutes of Health (Grant 5T1 HE 5550-02
Temporal response to harmonic driving in electroconvection
The temporal evolution of the spatially periodic electroconvection (EC)
patterns has been studied within the period of the driving ac voltage by
monitoring the light intensity diffracted from the pattern. Measurements have
been carried out on a variety of nematic systems, including those with negative
dielectric and positive conductivity anisotropy, exhibiting "standard EC"
(s-EC), those with both anisotropies negative exhibiting "non-standard EC"
(ns-EC), as well as those with the two anisotropies positive. Theoretical
predictions have been confirmed for stationary s-EC and ns-EC patterns.
Transitions with Hopf bifurcation have also been studied. While traveling had
no effect on the temporal evolution of dielectric s-EC, traveling conductive
s-EC and ns-EC patterns exhibited a substantially altered temporal behavior
with a dependence on the Hopf frequency. It has also been shown that in
nematics with both anisotropies positive, the pattern develops and decays
within an interval much shorter than the period, even at relatively large
driving frequencies.Comment: 19 pages, 5 figure
A preferential attachment model with random initial degrees
In this paper, a random graph process is studied and its
degree sequence is analyzed. Let be an i.i.d. sequence. The
graph process is defined so that, at each integer time , a new vertex, with
edges attached to it, is added to the graph. The new edges added at time
t are then preferentially connected to older vertices, i.e., conditionally on
, the probability that a given edge is connected to vertex i is
proportional to , where is the degree of vertex
at time , independently of the other edges. The main result is that the
asymptotical degree sequence for this process is a power law with exponent
, where is the power-law exponent
of the initial degrees and the exponent predicted
by pure preferential attachment. This result extends previous work by Cooper
and Frieze, which is surveyed.Comment: In the published form of the paper, the proof of Proposition 2.1 is
incomplete. This version contains the complete proo
Communications Biophysics
Contains reports on six research projects.National Institutes of Health (Grant 2 P01 GM-14940-01)Joint Services Electronics Programs (U. S. Army, U.S. Navy, and U.S. Air Force) under Contract DA 28-043-AMC-02536(E)National Aeronautics and Space Administration (Grant NsG-496)National Institutes of Health (Grant 2 ROl NB-05462-03
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