The Effects of Early Intervention on the Expressive Language Outcomes of Children with Autism Spectrum Disorder: A Systematic Review

Background: Autism Spectrum Disorder (ASD) is characterized by persistent challenges in social communication as well as restricted and repetitive behaviors and is often observable in early childhood. Expressive language delays are common in young children diagnosed with ASD. Expressive language includes any form of communicative output, such as verbal language, sign language, and the use of alternative and augmentative communication (AAC). Early intervention, for the purpose of this systematic review, is defined as speech and language services provided before a child is 5 years (60 months) of age. Evidence suggests that early intervention can lead to positive outcomes in the symptoms of children with ASD. Objective: To determine whether early intervention of ASD in children between 0-59 months of age has positive effects on expressive language development. Methods: A systematic search of the PsychINFO, PubMED, CINAHL, ERIC, and LLBA database was conducted, followed by a qualitative analysis of relevant articles. Studies included monolingual (i.e., English) children who were diagnosed with ASD. Studies were systematically graded and processed using inter-rater procedures. Results: Fourteen articles were included based upon inclusionary criteria. The overall quality of the studies was moderate. The most widely used early intervention techniques included the Early Start Denver Model (ESDM) and Pivotal Response Training (PRT). Conclusions: Consistent high-interval (i.e., 25 hours per week), behaviorally-based early intervention (i.e., before 40 months) may lead to positive outcomes in expressive language development. Clinicians working with young children with ASD should implement behaviorally-based, empirically-supported interventions, such as ESDM or PRT. Future research should prioritize high-quality study designs (e.g., randomized control trials) with larger sample sizes of children diagnosed with ASD, which is necessary to discern a direct relationship between behaviorally-based early intervention and expressive language outcomes for children with ASD.https://scholarworks.uvm.edu/csdms/1008/thumbnail.jp

Error tolerance in an NMR Implementation of Grover's Fixed-Point Quantum Search Algorithm

We describe an implementation of Grover's fixed-point quantum search algorithm on a nuclear magnetic resonance (NMR) quantum computer, searching for either one or two matching items in an unsorted database of four items. In this new algorithm the target state (an equally weighted superposition of the matching states) is a fixed point of the recursive search operator, and so the algorithm always moves towards the desired state. The effects of systematic errors in the implementation are briefly explored.Comment: 5 Pages RevTex4 including three figures. Changes made at request of referees; now in press at Phys Rev

Approximate quantum counting on an NMR ensemble quantum computer

We demonstrate the implementation of a quantum algorithm for estimating the number of matching items in a search operation using a two qubit nuclear magnetic resonance (NMR) quantum computer.Comment: 4 pages LaTeX/RevTex including 4 figures (3 LaTeX, 1 PostScript). Submitted to Physical Review Letter

Non-thermal plasma observations using EISCAT: Aspect angle dependence

Recent observations with the EISCAT incoherent scatter radar have shown large rises in dayside, auroral plasma velocities (>2 km s^{−1}) over a wide range of latitudes and lasting about an hour. These are larger than the neutral thermal speed, and allow, for the first time, observations of a non-thermal plasma over a range of observing angles, revealing a clear angular dependence. The observed ion temperature anisotropy, deduced by assuming a Maxwellian line-of-sight ion velocity distribution, is at least 1.75, which exceeds the theoretical value for a bi-Maxwellian based on a realistic ion-neutral collision model. The aspect angle dependence of the signal spectra also indicates non-Maxwellian plasma

Homogenization of Maxwell's equations in periodic composites

We consider the problem of homogenizing the Maxwell equations for periodic composites. The analysis is based on Bloch-Floquet theory. We calculate explicitly the reflection coefficient for a half-space, and derive and implement a computationally-efficient continued-fraction expansion for the effective permittivity. Our results are illustrated by numerical computations for the case of two-dimensional systems. The homogenization theory of this paper is designed to predict various physically-measurable quantities rather than to simply approximate certain coefficients in a PDE.Comment: Significantly expanded compared to v1. Accepted to Phys.Rev.E. Some color figures in this preprint may be easier to read because here we utilize solid color lines, which are indistinguishable in black-and-white printin

Classical model for bulk-ensemble NMR quantum computation

We present a classical model for bulk-ensemble NMR quantum computation: the quantum state of the NMR sample is described by a probability distribution over the orientations of classical tops, and quantum gates are described by classical transition probabilities. All NMR quantum computing experiments performed so far with three quantum bits can be accounted for in this classical model. After a few entangling gates, the classical model suffers an exponential decrease of the measured signal, whereas there is no corresponding decrease in the quantum description. We suggest that for small numbers of quantum bits, the quantum nature of NMR quantum computation lies in the ability to avoid an exponential signal decrease.Comment: 14 pages, no figures, revte

Synchronous Evolution of Galaxies in Groups: NGC 524 Group

By means of panoramic spectroscopy at the SAO RAS BTA telescope, we investigated the properties of stellar populations in the central regions of five early-type galaxies -- the NGC 524 group members. The evolution of the central regions of galaxies looks synchronized: the average age of stars in the bulges of all the five galaxies lies in the range of 3--6 Gyr. Four of the five galaxies revealed synchronized bursts of star formation in the nuclei 1--2 Gyr ago. The only galaxy, in which the ages of stellar population in the nucleus and in the bulge coincide (i.e. the nuclear burst of star formation did not take place) is NGC 502, the farthest from the center of the group of all the galaxies studied.Comment: Slightly edited version of the paper to appear in the Astrophysical Bulletin, 67(3); 24 pages including 8 figure

Observations of nonthermal plasmas at different aspect angles

Data are presented from the EISCAT (European Incoherent Scatter (Facility)) CP-3-E experiment which show large increases in the auroral zone convection velocities (>2 km s−1) over a wide range of latitudes. These are larger than the estimated neutral thermal speed and allow a study of the plasma in a nonthermal state over a range of observing angles. Spectra are presented which show a well-defined central peak, consistent with an ion velocity distribution function which significantly departs from a Maxwellian form. As the aspect angle decreases, the central peak becomes less obvious. Simulated spectra, derived using theoretical expressions for the O+ ion velocity distribution function based on the generalized relaxation collision model, are compared with the observations and show good first-order, qualitative agreement. It is shown that ion temperatures derived from the observations, with the assumption of a Maxwellian distribution function, are an overestimate of the true ion temperature at large aspect angles and an underestimate at low aspect angles. The theoretical distribution functions have been included in the “standard” incoherent scatter radar analysis procedure, and attempts have been made to derive realistic ionospheric parameters from nonthermal plasma observations. If the expressions for the distribution function are extended to include mixed ion composition, a significant improvement is found in fitting some of the observed spectra, and estimates of the ion composition can be made. The non-Maxwellian analysis of the data revealed that the spectral shape distortion parameter, D*, was significantly higher in this case for molecular ions than for atomic ions in a thin height slab roughly 40 km thick. This would seem unlikely if the main molecular ions present were NO+. We therefore suggest that N2+ formed a significant proportion of the molecular ions present during these observations

Gluino Contribution to the 3-loop QCD beta function in the Minimal Supersymmetric Standard Model

We deduce the gluino contribution to the three-loop QCD \beta function within the minimal supersymmetric Standard Model (MSSM) from its standard QCD expression. The result is a first step in the computation of the full MSSM three-loop \beta function. In addition, in the case of a light gluino it provides the strong three-loop SUSY correction to the extrapolation of the strong coupling constant from the low energy regime to the Z region and up to the squark threshold.Comment: 11 pages, RevTex, 4 Postscript figur