TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanisms underlying neurodegeneration in patients to create better therapeutic options. Recently, genetic studies uncovered novel AD risk variants in the microglial receptor, triggering receptor expressed on myeloid cells 2 (TREM2). Previous studies suggested that loss of TREM2 function worsens amyloid-β (Aβ) plaque-related toxicity. In contrast, we observe TREM2 deficiency mitigates neuroinflammation and protects against brain atrophy in the context of tau pathology. These findings indicate dual roles for TREM2 and microglia in the context of amyloid versus tau pathology, which are important to consider for potential treatments targeting TREM2.</jats:p

Stellar Subsystems of the Galaxy NGC 2366

Hubble Space Telescope archive data are used to perform photometry of stars in seven fields at the center and periphery of the galaxy NGC2366. The variation of the number density of stars of various ages with galactocentric radius and along the minor axis of the galaxy are determined. The boundaries of the thin and thick disks of the galaxy are found. The inferred sizes of the subsystems of NGC2366 ($Z_{thin} = 4$ kpc and $Z_{thick} = 8$ kpc for the thin and thick disks, respectively) are more typical for spiral galaxies. Evidence for a stellar halo is found at the periphery of NGC2366 beyond the thick disk of the galaxy.Comment: 16 pages, 4 figures, Astronomy Reports, 2008,v. 52, n.1, p. 1

Bose condensates in a harmonic trap near the critical temperature

The mean-field properties of finite-temperature Bose-Einstein gases confined in spherically symmetric harmonic traps are surveyed numerically. The solutions of the Gross-Pitaevskii (GP) and Hartree-Fock-Bogoliubov (HFB) equations for the condensate and low-lying quasiparticle excitations are calculated self-consistently using the discrete variable representation, while the most high-lying states are obtained with a local density approximation. Consistency of the theory for temperatures through the Bose condensation point requires that the thermodynamic chemical potential differ from the eigenvalue of the GP equation; the appropriate modifications lead to results that are continuous as a function of the particle interactions. The HFB equations are made gapless either by invoking the Popov approximation or by renormalizing the particle interactions. The latter approach effectively reduces the strength of the effective scattering length, increases the number of condensate atoms at each temperature, and raises the value of the transition temperature relative to the Popov approximation. The renormalization effect increases approximately with the log of the atom number, and is most pronounced at temperatures near the transition. Comparisons with the results of quantum Monte Carlo calculations and various local density approximations are presented, and experimental consequences are discussed.Comment: 15 pages, 11 embedded figures, revte

Broadband Observations of the Afterglow of GRB 000926: Observing the Effect of Inverse Compton Scattering and Evidence for a High-Density Environment

GRB 000926 has one of the best-studied afterglows to-date, with multiple X-ray observations, as well as extensive multi-frequency optical and radio coverage. Broadband afterglow observations, spanning from X-ray to radio frequencies, provide a probe of the density structure of the circumburst medium, as well as of the ejecta energetics, geometry, and the physical parameters of the relativistic blastwave resulting from the explosion. We present an analysis of {\em Chandra X-ray Observatory} observations of this event, along with {\em Hubble Space Telescope} and radio monitoring. We combine these data with ground-based optical and IR observations and fit the synthesized afterglow lightcurve using models where collimated ejecta expand into a surrounding medium. We find that we can explain the broadband lightcurve with reasonable physical parameters only if the cooling is dominated by inverse Compton scattering. Excess X-ray emission in the broadband spectrum indicates that we are directly observing a contribution from inverse Compton scattering. It is the first time this has been observed in a GRB afterglow, and it implies that the GRB exploded in a reasonably dense (n~30 cm^{-3}) medium, consistent with a diffuse interstellar cloud environment.Comment: 16 pages, 5 figures Accepted for publication in the Astrophysical Journa

Stellar disks and halos of the edge-on spiral galaxies: NGC 891, NGC 4144 and NGC 4244

The results of the stellar photometry of the images ACS/WFC and WFPC2 of the HST are used to study stellar population and spatial distribution of stars in three edge-on galaxies: NGC 891, NGC 4144 and NGC 4244. The measuring of the number density of the old stars revealed two stellar substructures in these galaxies: thick disk and halo. The borders of these substructures consisting mainly of red giants, are determined by the change of number density gradient of the old stars. The revealed halos have flattened shapes and extend up to 25 kpc from the galaxy planes. The obtained results of number density distributions of different type stars perpendicular to the galaxy planes allow us to verify our stellar model of spiral galaxies. Using the determination of the tip of red giant branch (TRGB method) we have derived the following distances: D = 9.82 Mpc (NGC 891), D = 7.24 Mpc (NGC 4144), D = 4.29 Mpc (NGC 4244).Comment: 18 pages, 9 figures. accepted to Astrofizic