First-in-class humanized FSH blocking antibody targets bone and fat

Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, structure, and function of a first-in-class, fully humanized, epitope-specific FSH blocking antibody with a KD of 7 nM. Protein thermal shift, molecular dynamics, and fine mapping of the FSH-FSH receptor interface confirm stable binding of the Fab domain to two of five receptor-interacting residues of the FSHβ subunit, which is sufficient to block its interaction with the FSH receptor. In doing so, the humanized antibody profoundly inhibited FSH action in cell-based assays, a prelude to further preclinical and clinical testing

Internet of things as a digital tool for the development of agricultural economy

The article analyzes the research results of a number of analytical agencies regarding the growth rate and key problems associated with the introduction of the “Internet of things” (IoT) in the agricultural economy. The issues of the development of the agro-industrial complex in the context of the development of the digital economy, the experience of introducing the digital economy in the agricultural sector of developed countries and the possibilities of its application in agriculture in Russia are considered. The authors focuses on the positive aspects of the influence of the “Internet of things” on the functioning and development of modern agricultural markets at the macro and micro levels, and the change in the professional structure of the agricultural industr