20 research outputs found
IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia
Get PDFCONCLUSION: STAT3 may be considered as a therapeutic target for cachectic patients with gastric, lung and breast cancer. Furthermore, IL-6 mediates STAT3 activation in cachectic gastric and breast cancer patients (Tab. 5, Fig. 2, Ref. 62)
BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile
No full textPMID = 3067206
Talazoparib nanoparticles for overcoming multidrug resistance in triple-negative breast cancer
No full textPMID = 3201707
Synthetically Lethal BMN 673 (Talazoparib) Loaded Solid Lipid Nanoparticles for BRCA1 Mutant Triple Negative Breast Cancer
No full textPMID = 3025545
Synergistic Effects of Nobiletin and Sorafenib Combination on Metastatic Prostate Cancer Cells
No full textPMID = 3103797
Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer
No full textPMID = 2971924
The Apoptotic Effects of Escin in The H-Ras Transformed 5RP7 Cell Line
No full textExtracts of Aesculus hippocastanum L. (horse chestnut) seed have been used in the treatment of chronic venous insufficiency, edema and hemorrhoids. Most of the beneficial effects of horse chestnut are attributed to its principal component -escin or escin. We have evaluated the cytotoxic and apoptotic effects of escin in the H-Ras 5RP7 cell line by analyzing cell growth inhibition, apoptosis and caspase-3 dependent activity. We have also shown structural and ultrastructural changes in these cell using confocal and transmission electron microscopy. The results indicated that escin has significant inhibitory effects on cell growth and the percentage of apoptotic cells increased after treatment with escin, and the micrographs confirmed that escin damaged these cells and induced apoptosis. Copyright (c) 2012 John Wiley & Sons, Ltd
Investigation of new treatment option for hepatocellular carcinoma: a combination of sorafenib with usnic acid
No full textPMID = 3102537
