Racking Performance of Plasterboard-Clad Steel Stud Walls

It is recognised that structural design efficiency in domestic and similar structures can be improved when the composite behaviour and contribution of all materials in the permanent structure can be fully recognised in the structural design of the frame. The ability to achieve this Improvement is currently limited by the need 10 rely on empirical test results for standardised building elements when considering the composite behaviour of the entire structure. The existing test methodology for determining the shear strength of plasterboard lined steel stud walls leads to an excessively conservative design of the complete structure. Since the test configuration is for isolated test panels, the absence of continuity of the plasterboard lining around a set corner is not included in the test procedure. A test program has been devised and carried out to explore the effect of the set corner on the performance of shear test panels. A dramatic improvement in both diaphragm shear strength and shear stiffness has been achieved in these tests supporting a proposal to amend the standard lest methodology to Include set corners

Belfast Without Sight: Exploring Geographies of Blindness

In this paper (he transformed spaces of visually impaired and blind people is explored through a detailed analysis of interview transcripts with twenty seven visually impaired people living in or around Belfast. Data were collected using a structured open-ended interview and were analysed within NUD-IST, a qualitative data analysis package. Analysis revealed that visually impaired people become spatially confused (e.g. lost or disorientated) for two primary reasons. "Self-produced" confusion is spatial confusion caused by the misperception/miscognition of a route (e.g. miscounting intersections). "Situational" confusion is spatial confusion caused by a permanent or temporary localised occurrences such as road works, vehicles parked on pavements, and street furniture. Both types of spatial confusion were found to induce feelings of fear and anxiety, leading to a loss of selfconfidence, embarrassment and frustration, which in turn led to less independent travel and exploration, and constrained patterns of spatial behaviour. Respondents detailed a number of strategies for coping with spatial confusion. In addition, they assessed methods to make Belfast more navigable including environmental modifications and orientation and mobility aid

Belfast Without Sight: Exploring Geographies of Blindness

In this paper (he transformed spaces of visually impaired and blind people is explored through a detailed analysis of interview transcripts with twenty seven visually impaired people living in or around Belfast. Data were collected using a structured open-ended interview and were analysed within NUD-IST, a qualitative data analysis package. Analysis revealed that visually impaired people become spatially confused (e.g. lost or disorientated) for two primary reasons. "Self-produced" confusion is spatial confusion caused by the misperception/miscognition of a route (e.g. miscounting intersections). "Situational" confusion is spatial confusion caused by a permanent or temporary localised occurrences such as road works, vehicles parked on pavements, and street furniture. Both types of spatial confusion were found to induce feelings of fear and anxiety, leading to a loss of selfconfidence, embarrassment and frustration, which in turn led to less independent travel and exploration, and constrained patterns of spatial behaviour. Respondents detailed a number of strategies for coping with spatial confusion. In addition, they assessed methods to make Belfast more navigable including environmental modifications and orientation and mobility aid

The Effect of Spatial Tasks on Visually Impaired Peoples' Wayfinding Abilities

Thirty-eight people with visual impairments learned a 483-meter novel route through a university campus in four groups: verbalization, modeling, pointing, and control. The performance of all four groups improved with greater experience of the route, but the modeling group improved more than did the control group

Antarctic climate and ice-sheet configuration during the early Pliocene interglacial at 4.23Ma

The geometry of Antarctic ice sheets during warm periods of the geological past is difficult to determine from geological evidence, but is important to know because such reconstructions enable a more complete understanding of how the ice-sheet system responds to changes in climate. Here we investigate how Antarctica evolved under orbital and greenhouse gas conditions representative of an interglacial in the early Pliocene at 4.23Ma, when Southern Hemisphere insolation reached a maximum. Using offline-coupled climate and ice-sheet models, together with a new synthesis of high-latitude palaeoenvironmental proxy data to define a likely climate envelope, we simulate a range of ice-sheet geometries and calculate their likely contribution to sea level. In addition, we use these simulations to investigate the processes by which the West and East Antarctic ice sheets respond to environmental forcings and the timescales over which these behaviours manifest. We conclude that the Antarctic ice sheet contributed 8.6±2.8m to global sea level at this time, under an atmospheric CO2 concentration identical to present (400ppm). Warmer-than-present ocean temperatures led to the collapse of West Antarctica over centuries, whereas higher air temperatures initiated surface melting in parts of East Antarctica that over one to two millennia led to lowering of the ice-sheet surface, flotation of grounded margins in some areas, and retreat of the ice sheet into the Wilkes Subglacial Basin. The results show that regional variations in climate, ice-sheet geometry, and topography produce long-term sea-level contributions that are non-linear with respect to the applied forcings, and which under certain conditions exhibit threshold behaviour associated with behavioural tipping points

Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): Study protocol for a randomised controlled trial

Background: Abdominal aortic aneurysm (AAA) is a slowly progressive destructive process of the main abdominal artery. Experimental studies indicate that fibrates exert beneficial effects on AAAs by mechanisms involving both serum lipid modification and favourable changes to the AAA wall. Methods/design: Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME) is a multicentre, randomised, double-blind, placebo-controlled clinical trial to assess the effect of orally administered therapy with fenofibrate on key pathological markers of AAA in patients undergoing open AAA repair. A total of 42 participants scheduled for an elective open AAA repair will be randomly assigned to either 145 mg of fenofibrate per day or identical placebo for a minimum period of 2 weeks prior to surgery. Primary outcome measures will be macrophage number and osteopontin (OPN) concentration within the AAA wall as well as serum concentrations of OPN. Secondary outcome measures will include levels of matrix metalloproteinases and proinflammatory cytokines within the AAA wall, periaortic fat and intramural thrombus and circulating concentrations of AAA biomarkers. Discussion: At present, there is no recognised medical therapy to limit AAA progression. The FAME trial aims to assess the ability of fenofibrate to alter tissue markers of AAA pathology. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12612001226897. Registered on 20 November 2012. © 2017 The Author(s)

Effects of a 6-month exercise program pilot study on walking economy, peak physiological characteristics, and walking performance in patients with peripheral arterial disease

The purpose of this study was to examine the effects of a 6-month exercise program on submaximal walking economy in individuals with peripheral arterial disease and intermittent claudication (PAD-IC). Participants (n = 16) were randomly allocated to either a control PAD-IC group (CPAD-IC, n = 6) which received standard medical therapy, or a treatment PAD-IC group (TPAD-IC; n = 10) which took part in a supervised exercise program. During a graded treadmill test, physiological responses, including oxygen consumption, were assessed to calculate walking economy during submaximal and maximal walking performance. Differences between groups at baseline and post-intervention were analyzed via Kruskal–Wallis tests. At baseline, CPAD-IC and TPAD-IC groups demonstrated similar walking performance and physiological responses. Postintervention, TPAD-IC patients demonstrated significantly lower oxygen consumption during the graded exercise test, and greater maximal walking performance compared to CPAD-IC. These preliminary results indicate that 6 months of regular exercise improves both submaximal walking economy and maximal walking performance, without significant changes in maximal walking economy. Enhanced walking economy may contribute to physiological efficiency, which in turn may improve walking performance as demonstrated by PAD-IC patients following regular exercise programs

Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes

Aims: We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results: This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications. Conclusion: This study demonstrates that fasting triglycerides of ≥200 mg/dL are associated with an increased risk of CVD mortality in patients with diabetes but not in those without diabetes. Future clinical trials of new treatments to lower triglycerides should focus on patients with diabetes