Gold nanoparticles as novel agents for cancer therapy

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitisers with ionising radiation in vitro and in vivo at kilovoltage and megavoltage energies is discussed

A Constant Bar Fraction out to Redshift z~1 in the Advanced Camera for Surveys Field of the Tadpole Galaxy

Bar-like structures were investigated in a sample of 186 disk galaxies larger than 0.5 arcsec that are in the I-band image of the Tadpole galaxy taken with the HST ACS. We found 22 clear cases of barred galaxies, 21 galaxies with small bars that appear primarily as isophotal twists in a contour plot, and 11 cases of peculiar bars in clump-cluster galaxies, which are face-on versions of chain galaxies. The latter bars are probably young, as the galaxies contain only weak interclump emission. Four of the clearly barred galaxies at z~0.8-1.2 have grand design spirals. The bar fraction was determined as a function of galaxy inclination and compared with the analogous distribution in the local Universe. The bar fraction was also determined as a function of galaxy angular size. These distributions suggest that inclination and resolution effects obscure nearly half of the bars in our sample. The bar fraction was also determined as a function of redshift. We found a nearly constant bar fraction of 0.23+-0.03 from z~0 to z=1.1. When corrected for inclination and size effects, this fraction is comparable to the bar fraction in the local Universe, ~0.4, as tabulated for all bar and Hubble types in the Third Reference Catalogue of Galaxies. The average major axis of a barred galaxy in our sample is ~10 kpc after correcting for redshift with a LambdaCDM cosmology. Galaxy bars were present in normal abundance at least ~8 Gy ago (z~1); bar dissolution cannot be common during a Hubble time unless the bar formation rate is comparable to the dissolution rate.Comment: to appear in ApJ, Sept 1, 2004, Vol 612, 18 pg, 12 figure

'Selling it as a holistic health provision and not just about condoms ?' Sexual health services in school settings: current models and their relationship with sex and relationships education policy and provision

In this article we discuss the findings from a recent study of UK policy and practice in relation to sexual health services for young people, based in - or closely linked with - schools. This study formed part of a larger project, completed in 2009, which also included a systematic review of international research. The findings discussed in this paper are based on analyses of interviews with 51 service managers and questionnaire returns from 205 school nurses. Four themes are discussed. First, we found three main service permutations, in a context of very diverse and uneven implementation. Second, we identified factors within the school context that shaped and often constrained service provision; some of these also have implications for sex and relationships education (SRE). Third, we found contrasting approaches to the relationship between SRE input and sexual health provision. Fourth, we identified some specific barriers that need to be addressed in order to develop 'young people friendly' services in the school context. The relative autonomy available to school head teachers and governors can represent an obstacle to service provision - and inter-professional collaboration - in a climate where, in many schools, there is still considerable ambivalence about discussing 'sex' openly. In conclusion, we identify areas worthy of further research and development, in order to address some obstacles to sexual health service and SRE provision in schools

Orbital Kondo Effect in Cex_xLa1−x_{1-x}B6_6: Scaling Analysis

Peculiarity of the Kondo effect in Ce$_x$La$_{1-x}$B$_6$ is investigated on the basis of the scaling equations up to third order. For the case where the $f^1$-$f^2$ charge fluctuation enters in addition to the $f^1$-$f^0$ one, the effective exchange interaction becomes anisotropic with respect to the orbital pseudospins which represent the two different orbitals in the $\Gamma_8$ ground state. Because of different characteristic energies for electric and magnetic tensors, scaling with the single Kondo temperature does not apply to physical quantities such as the resistivity and magnetic susceptibility. Possibility of a bizzare phase is pointed out where the RKKY interaction leads to the spin ordering without orbital ordering. This phase serves as a candidate of the phase IV which is observed to be isotropic magnetically.Comment: 10 pages, 4 eps figures, submitted to PR

New broad 8Be nuclear resonances

Energies, total and partial widths, and reduced width amplitudes of 8Be resonances up to an excitation energy of 26 MeV are extracted from a coupled channel analysis of experimental data. The presence of an extremely broad J^pi = 2^+ ``intruder'' resonance is confirmed, while a new 1^+ and very broad 4^+ resonance are discovered. A previously known 22 MeV 2^+ resonance is likely resolved into two resonances. The experimental J^pi T = 3^(+)? resonance at 22 MeV is determined to be 3^-0, and the experimental 1^-? (at 19 MeV) and 4^-? resonances to be isospin 0.Comment: 16 pages, LaTe

Crossover between Fermi Liquid and non-Fermi Liquid in Orbitally Degenerate Kondo Systems

Entanglement of spin and orbital Kondo effect is investigated on the basis of a Kondo-type exchange model with twofold orbital degeneracy. By using Wilson's numerical renormalization-group method, we examine dynamical and thermal properties respecting the difference in time-reversal property of multipole operators. In the presence of particle-hole symmetry, the model has a new non-Fermi-liquid fixed point with a fractional entropy. The spectral intensity of the quadrupole susceptibility diverges in the zero-frequency limit, while the dipole susceptibility shows a Fermi-liquid-like behavior. This is understood by mapping to the two-channel Kondo model, in which the dipole moment is mapped onto the operators with the scaling dimension $\Delta_m=1$, while the quadrupole moment onto the operators with another scaling dimension $\Delta_e=1/2$. Even for a fairly particle-hole asymmetric case with the Fermi-liquid ground state, the non-Fermi-liquid behavior has significant influences in electric and thermal properties.Comment: 7 pages, 9 figures, to appear in J. Phys Soc. Jpn. Vol. 68 No. 12, title changed and some corrections mad

Self-similar disk packings as model spatial scale-free networks

The network of contacts in space-filling disk packings, such as the Apollonian packing, are examined. These networks provide an interesting example of spatial scale-free networks, where the topology reflects the broad distribution of disk areas. A wide variety of topological and spatial properties of these systems are characterized. Their potential as models for networks of connected minima on energy landscapes is discussed.Comment: 13 pages, 12 figures; some bugs fixed and further discussion of higher-dimensional packing

Deepening democracy within Ireland's social partnership

Ireland's social partnership process, now under attack from a number of quarters, has repeatedly been charged with being 'undemocratic' in that it undermines the sovereign position of elected political representatives, with key policy formulation and decision-making taking place in fora outside the institutions of representative democracy. These critiques echo those against new forms of networked governance more globally. A key question therefore is how (and if) democracy may be deepened within social partnership or its potential successor(s). This article addresses this question by employing a post-liberal democratic framework to examine social partnership in practice, and by drawing lessons from another partnership process, Malawi's PRSP. Drawing from Malawi's experience, it is argued that democracy can be deepened within social partnership when governance deliberations and negotiations are conducted under conditions of vibrant public debate and genuine perspective-based representation, and when the communicative and discursive norms are widened to allow for such representation