Studies on the denaturation of antibody: II. The effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea

The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed

Studies on the denaturation of antibody. IV. The influence of pH and certain other factors on the rate of inactivation of Staphylococcus antitoxin in urea solutions

In previous work on the denaturation of antibody, studies have been made of some of the factors influencing the inactivation of diphtheria antitoxin in urea solutions (1, 2). A quantitative formulation of a simple kinetic theory was found to fit satisfactorily the experimental data and to offer a reasonable explanation of the deviation of the inactivation from simple first order behavior (2). In the present work we have studied the inactivation of Staphylococcus antitoxin, investigating the influence of certain new factors on the rate and course of the over-all reaction, with a view toward gaining further insight into the mechanism of the reactions, and reinvestigating the influence of pH, a factor studied previously with diphtheria antitoxin, in order to test the applicability of the proposed kinetic mechanism to different antibodies

A Third Planet Orbiting HIP 14810

We present new precision radial velocities and a three-planet Keplerian orbit fit for the V = 8.5, G5 V star HIP 14810. We began observing this star at Keck Observatory as part of the N2K Planet Search Project. Wright et al. (2007) announced the inner two planets to this system, and subsequent observations have revealed the outer planet planet and the proper orbital solution for the middle planet. The planets have minimum masses of 3.9, 1.3, and 0.6 M_Jup and orbital periods of 6.67, 147.7, and 952 d, respectively. We have numerically integrated the family of orbital solutions consistent with the data and find that they are stable for at least 10^6 yr. Our photometric search shows that the inner planet does not transit.Comment: ApJL, accepte

Voltage regulator with plural parallel power source sections Patent

Dissipative voltage regulator system for minimizing heat dissipatio

Voltage regulator with multiple parallel power source sections

Voltage regulator provides improved voltage-regulating system in which power dissipation and consequent heat generation are minimized. Each power source section is controlled sequentially so that only one operates in a linear range at a time

People with learning disabilities and mental health problems: the impact of ethnicity

There is increasing awareness of the needs of people with learning disabilities from different ethnic communities. This paper focuses on the impact of ethnicity on the presentation of mental health problems. The main aim of the paper is to inform those planning and delivering mental health services for people with learning disabilities of the current evidence, in order to enable their practice to improve health outcomes for people from minority ethnic communitie

Neural networks based recognition of 3D freeform surface from 2D sketch

In this paper, the Back Propagation (BP) network and Radial Basis Function (RBF) neural network are employed to recognize and reconstruct 3D freeform surface from 2D freehand sketch. Some tests and comparison experiments have been made to evaluate the performance for the reconstruction of freeform surfaces of both networks using simulation data. The experimental results show that both BP and RBF based freeform surface reconstruction methods are feasible; and the RBF network performed better. The RBF average point error between the reconstructed 3D surface data and the desired 3D surface data is less than 0.05 over all our 75 test sample data

The 20/30 GHz satellite systems technology needs assessment

Rain attenuation in the 20/30 GHz bands, and the resultant impact on system user costs were estimated for a variety of satellite communication system concepts. Results of previous and current NASA Lewis contractual and in-house studies on system design are reported as well as market studies conducted to evaluate the concepts and test their relevancy against forecasted market needs. The 20/30 GHz bands appear attractive economically and, with certain technology, appear to offer a virtually unlimited spectrum resource. This attractiveness is especially relevant to high density trunking where there is sufficient traffic to justify dual-station site diversity