An integrated pharmacokinetic and imaging evaluation of vehicle effects on solute human epidermal flux and, retention characteristics

Objective. Our understanding of the differential effects of topically applied vehicles on solute partitioning and diffusion within the skin is presently limited. In this work, in vitro epidermal partitioning, penetration and multiphoton laser scanning microscopy (MPLSM) imaging studies were used to assess the distribution of 2-naphthol across human epidermis