87 research outputs found
Multiplexing Biochemical Signals
In this paper we show that living cells can multiplex biochemical signals,
i.e. transmit multiple signals through the same signaling pathway
simultaneously, and yet respond to them very specifically. We demonstrate how
two binary input signals can be encoded in the concentration of a common
signaling protein, which is then decoded such that each of the two output
signals provides reliable information about one corresponding input. Under
biologically relevant conditions the network can reach the maximum amount of
information that can be transmitted, which is 2 bits.Comment: 4 pages, 4 figure
Largest ancient fortress of South-West Asia and the western world?:Recent fieldwork at Sasanian Qaleh Iraj at Pishva, Iran
The article presents recent works at Qale Iraj, near Varamin, Iran. My short contribution is on the Middle Persian ostraka found at the site
Séance publique du 19 février 1949
Wiet Gaston, Castelnuovo G. Séance publique du 19 février 1949. In: Bulletin de l'Institut d'Egypte, tome 31, 1948. pp. 432-436
The Real Need for Regenerative Medicine in the Future of Congenital Heart Disease Treatment
Bioabsorbable materials made from polymeric compounds have been used in many fields of regenerative medicine to promote tissue regeneration. These materials replace autologous tissue and, due to their growth potential, make excellent substitutes for cardiovascular applications in the treatment of congenital heart disease. However, there remains a sizable gap between their theoretical advantages and actual clinical application within pediatric cardiovascular surgery. This review will focus on four areas of regenerative medicine in which bioabsorbable materials have the potential to alleviate the burden where current treatment options have been unable to within the field of pediatric cardiovascular surgery. These four areas include tissue-engineered pulmonary valves, tissue-engineered patches, regenerative medicine options for treatment of pulmonary vein stenosis and tissue-engineered vascular grafts. We will discuss the research and development of biocompatible materials reported to date, the evaluation of materials in vitro, and the results of studies that have progressed to clinical trials
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