Spectrophotometric method for estimation of desvenlafaxine succinate in tablet dosage form

ABSTRACT Two simple and sensitive spectrophotometric methods (A and B) for the determination of desvenlafaxine succinate in tablet dosage form are described. In the method A -Simple UV Spectrophotometric method, distilled water was used as solvent and shows absorption maxima at 224.5 nm. In the method B -Difference Spectrophotometric method, the proposed method is based on the principle that desvenlafaxine succinate can exhibit two different chemical form in basic and acidic medium that differ in the absorption spectra in basic and acidic medium. The difference spectrum of desvenlafaxine succinate in 0.01 M Sodium hydroxide was recorded by taking desvenlafaxine succinate in 0.1 M Hydrochloric acid solution as blank. The difference spectrum showed that the maxima at 240 nm and minima at 224.5 nm. The Beer's law range for method A is 5 -40 µg/mL and 8 -40 µg/mL for method B. The linear regression for method A and B are found to be 0.99992 and 0.99994 respectively. When tablet dosage form where analyzed, the results are obtained by the proposed methods are in good agreement with the labeled amount and the results were validated statistically

Morphological investigations of self-assembled films from a pyridine -incorporated poly (p-phenylene)

10.1007/s10934-006-8023-4Journal of Porous Materials133315-317JPMA

Oxidation of cyclohexene in a simple capillary-microreactor

10.1142/S0219581X05003310International Journal of Nanoscience44599-60

Reactivity of Tetrabutylammonium Iodide with a Heteronuclear 6Copper(II)–4Na(I) Complex: Selective Recognition of Iodide Ion

A complex of type [Cu6Na4(μ-O)4(NTA)2(bpy)6(H2O)4(NO3)2]·3H2O 1 was allowed to react separately with tetrabutylammonium salts (TBAX), X = F–, Cl–, Br–, I–, AcO–, NO3–, and H2PO4–. The color of complex 1 changed immediately on the addition of TBAI (tetrabutylammonium iodide) only. However, keeping the corresponding solution for 2 months at room temperature, four complexes of compositions [Cu6(μ-OH)4(NTA)2(bpy)6]2I–·5H2O 2, [Cu2(bpy)2(OH)2(I)]2(NO3)2(H2O) 3, [Cu(bpy)2I]I3– 4, and [Cu(bpy)2I]I·TBAI 5 (bpy = 2,2′-bipyridyl, H3NTA = nitrilotriacetic acid) together with some residues of TBAI and complex 1 were isolated in one-pot synthesis. These complexes were characterized using elemental analysis, spectroscopic (IR, UV–vis) and single crystal X-ray diffraction techniques. Colorimetric response of complex 1 with iodide anions was further supported by the changes in its UV–vis spectra recorded in methanol. The results indicated that 1 exhibits a strong affinity for iodide anions