Hydrothermal synthesis and sorption performance to Cs(I) and Sr(II) of zirconia-analcime composites derived from coal fly ash cenospheres

The paper is concerned with (i) the hydrothermal synthesis of hydrous zirconium dioxide (HZD) bearing analcime (HZD-ANA, zirconia-analcime) and (ii) its sorption properties with respect to Cs+ and Sr2+. The HZD-ANA particles were synthesized from coal fly ash cenospheres composed of aluminosilicate glass with (SiO2/Al2O3)wt.=3.1 and characterized by PXRD, SEM-EDS, STA, and low-temperature N2 adsorption. The non-radioactive simulant solutions of different acidity (pH=2–10) and Cs+/Sr2+ content (0.5–50.0 mg/L) were used in the work. The effect of synthesis conditions on the HZD-ANA particle size, zirconia content and localization as well as the sorption behavior with respect to Cs+ and Sr2+ (capacity, KD) were clarified. It was found that the small-sized HZD-ANA composites surpasses the Zr free analcime and large-sized HZD-ANA material in the Cs+ and Sr2+ sorption parameters (KD ~104–106 mL/g). The conditions to synthesize the zirconia-analcime composite of the highly enhanced sorption ability with respect to Sr2+ (KD ~106 mL/g) were determined. The high-temperature solid-phase re-crystallization of Cs+/Sr2+-exchanged HZD-ANA composites was shown to occur at 1000 °C resulting in a polyphase system based on nepheline, tetragonal ZrO2, and glass phase

MANAGEMENT ACTIVITIES EFFECTIVENESS IN MODERN RUSSIAN INSTITUTION IN THE CONTEXT OF HEAD WORKPLACE MODELING

Purpose: The scientific approach to the organization of labor and the workplace of the institution head involves the search for the most optimal model or technique acceptable to the Russian conditions within the current management culture, traditional views on the nature of managerial work, the scale and effectiveness of management activities. Methodology: Methodological guidelines for the study of workplaces’ organization of credit and financial institutions’ heads are based on the provisions of modern ergonomics and the principles of a system-based approach, allowing justifying as a significant one the environment-oriented approach. Result: The obtained results served as the basis for the development of appropriate recommendations to optimize the current situation in the context of eliminating existing gaps and problems in the credit and financial sector of the Russian economy from the standpoint of optimizing the process of organizing working places for managers of institutions in this profile. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of the Management Activities Effectiveness in Modern Russian Institution in the context of Head Workplace Modeling is presented in a comprehensive and complete manner

Experimental and Theoretical Study of the Electronic and Steric Structure of Seleno- and Thioacetals

The molecular-orbital and conformational characteristics of a series of seleno- and thioacetals were studied by photoelectron spectroscopy, spectrophotometry of charge-transfer complexes, and PM3 semi-empirical quantum chemical method. The decisive contribution to the HOMO in these compounds is made by the heteroatom bound to the aromatic system, and the characteristics of the second highest occupied molecular orbital depend on the nature of the heteroatoms in the acetal moiety. The stable conformations of the fragments E-CH2-E-CH3 and Ar-Se-CH2-O are trans and gauche, respectively

Theoretical conformational analysis of cyclic organophosphorus and organosilicon compounds

The structure of some six- and eight-membered phosphorus and silicon heterocycles was established by the method of dipole moments and density functional theory calculations. There are two necessary conditions for the feasibility of the transannular interaction in these heterocycles: (1) the favorable disposition of the donor and acceptor centers in a molecule and (2) the presence of the substituents with the considerable polarizing effect at the heteroatom. Copyright © Taylor & Francis Group, LLC

Experimental and theoretical conformational analysis of methylene- and cyanophosphines and their oxides

The structure of a great number of methylenephosphine oxides 1-11 and cyanophosphines and their oxides 12-18 was studied by semiempirical PM3 and ab initio RHF/6-31G** calculations. Obtained results are in good agreement with experimental data (dipole moments, Kerr effect, IR spectroscopy). In 12-18 the contribution of interactions of CN group or Ph ring with lone pair of electrons (LPE) of the P atom, d-orbitals of the P atom, or P=O group is absent

DYNAMICS OF ANTIBIOTIC RESISTANCE OF NOSOCOMIAL PATHOGENS AND STATE OF ANTIBIOTiC THERAPY IN MULTIFIELD CLINIC

We carried out comparative analysis of the results of microbiological researches and antibiotic resistance of main pathogens of nosocomial infections from 2005 to 2010 years. During this period quota of MRSE (65—74 %), MRSA (22,7—35 %) is stably high and. especially quota of producers of different β-lactamases among other Enterobacteriaceae pathogens (3,2—65 %) increased that caused, significant expenses for antibiotic therapy by carbapenems (22,7—40 %), glycopeptides (2,7—10 %). Monitoring of tendencies of resistance of the most important pathogens of hospital infections optimication of antimicrobial therapy and introduction, of the system of preventive measures allowed, to decrease economic expenses for antimicrobial means to 17,5 %

Mapping an atlas of tissue-specific drosophila melanogaster metabolomes by high resolution mass spectrometry

Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues. Comprehensive metabolite profiles for ten tissues from adult Drosophila melanogaster were obtained here by two chromatographic methods, a hydrophilic interaction (HILIC) method for polar metabolites and a lipid profiling method also based on HILIC, in combination with an Orbitrap Exactive instrument. Two hundred and forty two polar metabolites were putatively identified in the various tissues, and 251 lipids were observed in positive ion mode and 61 in negative ion mode. Although many metabolites were detected in all tissues, every tissue showed characteristically abundant metabolites which could be rationalised against specific tissue functions. For example, the cuticle contained high levels of glutathione, reflecting a role in oxidative defence; the alimentary canal (like vertebrate gut) had high levels of acylcarnitines for fatty acid metabolism, and the head contained high levels of ether lipids. The male accessory gland uniquely contained decarboxylated S-adenosylmethionine. These data thus both provide valuable insights into tissue function, and a reference baseline, compatible with the FlyAtlas.org transcriptomic resource, for further metabolomic analysis of this important model organism, for example in the modelling of human inborn errors of metabolism, aging or metabolic imbalances such as diabetes

3-Aryl(hetaryl)-3-hydroxy-2-phosphorus-substituted acrylonitriles. Synthesis and experimental and theoretical conformational analysis

Under conditions of the phase transfer catalysis, acylation of (thio)phosphorylacetonitriles by (het)aroyl chlorides affords the Z-enol forms of C-acylation products in high yields. Their configurations were studied by IR spectroscopy, dipole moment measurements, and ab initio quantum-chemical calculations [B3LYP/6-31G(d)]. The C=C double bond and the phosphoryl or thiophosphoryl group have an s-cis arrangement. The possibility of strong intramolecular hydrogen bonding in these conformers is the governing factor responsible for the three-dimensional structures of the compounds under investigation. Derivatives of nicotinic acid existing in the individual form as zwitterions are the only exceptions

Synthesis and structure of 1-bromo-1-nitro-2-piperidino-(cyclohexylamino)-2-phenylethenes

A preparation method was developed for new representatives of halonitroenamines, 1-bromo-1-nitro-2-piperidino(cyclohexylamino)-2-phenylethenes. Both molecules possess E configuration and are of high polarity

Drosophila Uri, a PP1α binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity

<p>Abstract</p> <p>Background</p> <p>Protein phosphatase 1 (PP1) is involved in diverse cellular processes, and is targeted to substrates via interaction with many different protein binding partners. PP1 catalytic subunits (PP1c) fall into PP1α and PP1β subfamilies based on sequence analysis, however very few PP1c binding proteins have been demonstrated to discriminate between PP1α and PP1β.</p> <p>Results</p> <p>URI (unconventional prefoldin RPB5 interactor) is a conserved molecular chaperone implicated in a variety of cellular processes, including the transcriptional response to nutrient signalling and maintenance of DNA integrity. We show that <it>Drosophila </it>Uri binds PP1α with much higher affinity than PP1β, and that this ability to discriminate between PP1c forms is conserved to humans. Most Uri is cytoplasmic, however we found some protein associated with active RNAPII on chromatin. We generated a <it>uri </it>loss of function allele, and show that <it>uri </it>is essential for viability in <it>Drosophila</it>. <it>uri </it>mutants have transcriptional defects, reduced cell viability and differentiation in the germline, and accumulate DNA damage in their nuclei.</p> <p>Conclusion</p> <p>Uri is the first PP1α specific binding protein to be described in <it>Drosophila</it>. Uri protein plays a role in transcriptional regulation. Activity of <it>uri </it>is required to maintain DNA integrity and cell survival in normal development.</p